全文获取类型
收费全文 | 5493篇 |
免费 | 743篇 |
国内免费 | 338篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 20篇 |
妇产科学 | 21篇 |
基础医学 | 337篇 |
口腔科学 | 46篇 |
临床医学 | 353篇 |
内科学 | 406篇 |
皮肤病学 | 183篇 |
神经病学 | 103篇 |
特种医学 | 58篇 |
外科学 | 231篇 |
综合类 | 1187篇 |
预防医学 | 190篇 |
眼科学 | 29篇 |
药学 | 981篇 |
1篇 | |
中国医学 | 2285篇 |
肿瘤学 | 131篇 |
出版年
2024年 | 57篇 |
2023年 | 129篇 |
2022年 | 187篇 |
2021年 | 268篇 |
2020年 | 193篇 |
2019年 | 173篇 |
2018年 | 174篇 |
2017年 | 231篇 |
2016年 | 259篇 |
2015年 | 206篇 |
2014年 | 394篇 |
2013年 | 369篇 |
2012年 | 400篇 |
2011年 | 458篇 |
2010年 | 372篇 |
2009年 | 289篇 |
2008年 | 243篇 |
2007年 | 313篇 |
2006年 | 269篇 |
2005年 | 232篇 |
2004年 | 203篇 |
2003年 | 200篇 |
2002年 | 170篇 |
2001年 | 187篇 |
2000年 | 112篇 |
1999年 | 91篇 |
1998年 | 59篇 |
1997年 | 66篇 |
1996年 | 36篇 |
1995年 | 47篇 |
1994年 | 28篇 |
1993年 | 30篇 |
1992年 | 17篇 |
1991年 | 30篇 |
1990年 | 15篇 |
1989年 | 10篇 |
1988年 | 7篇 |
1987年 | 6篇 |
1986年 | 3篇 |
1985年 | 17篇 |
1984年 | 10篇 |
1983年 | 4篇 |
1982年 | 1篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1978年 | 3篇 |
1974年 | 1篇 |
1973年 | 1篇 |
排序方式: 共有6574条查询结果,搜索用时 15 毫秒
991.
992.
993.
任海平 《世界中西医结合杂志》2010,5(12):1070-1071
目的观察中药面膜联合煎剂内服治疗寻常性痤疮临床疗效。方法将137例痤疮患者随机分为72例中药治疗组和65例西药对照组,中药治疗组采用内服中药痤疮煎剂联合中药面膜外用治疗;西药对照组采用口服美满霉素片0.1g,1日2次,维生素B620mg,1日2次,外涂0.1%维A酸霜。结果中药治疗组有效率86.11%,西药治疗组有效率为66.15%,两组比较,差异有统计学意义(P0.01)。结论中药面膜联合煎剂内服治疗寻常性痤疮,有疗效短、见效快、无副作用、治愈率高且不易复发等优点,疗效明显优于西药对照组,值得临床推广应用。 相似文献
994.
(Headache 2011;51:1078‐1086) Background.— Therapeutic needs of migraineurs vary considerably from patient to patient and even attack to attack. Some attacks require high‐end therapy, while other attacks have treatment needs that are less immediate. While triptans are considered the “gold standard” of migraine therapy, they do have limitations and many patients are seeking other therapeutic alternatives. In 2005, an open‐label study of feverfew/ginger suggested efficacy for attacks of migraine treated early during the mild headache phase of the attack. Methods/Materials.— In this multi‐center pilot study, 60 patients treated 221 attacks of migraine with sublingual feverfew/ginger or placebo. All subjects met International Headache Society criteria for migraine with or without aura, experiencing 2‐6 attacks of migraine per month within the previous 3 months. Subjects had <15 headache days per month and were not experiencing medication overuse headache. Inclusion required that subjects were able to identify a period of mild headache in at least 75% of attacks. Subjects were required to be able to distinguish migraine from non‐migraine headache. Subjects were randomized 3:1 to receive either sublingual feverfew/ginger or a matching placebo and were instructed but not required to treat with study medication at the earliest recognition of migraine. Results.— Sixty subjects treated 208 evaluable attacks of migraine over a 1‐month period; 45 subjects treated 163 attacks with sublingual feverfew/ginger and 15 subjects treated 58 attacks with a sublingual placebo preparation. Evaluable diaries were completed for 151 attacks of migraine in the population using feverfew/ginger and 57 attacks for those attacks treated with placebo. At 2 hours, 32% of subjects receiving active medication and 16% of subjects receiving placebo were pain‐free (P = .02). At 2 hours, 63% of subjects receiving feverfew/ginger found pain relief (pain‐free or mild headache) vs 39% for placebo (P = .002). Pain level differences on a 4‐point pain scale for those receiving feverfew/ginger vs placebo were ?0.24 vs ?0.04 respectively (P = .006). Feverfew/ginger was generally well tolerated with oral numbness and nausea being the most frequently occurring adverse event. Conclusion.— Sublingual feverfew/ginger appears safe and effective as a first‐line abortive treatment for a population of migraineurs who frequently experience mild headache prior to the onset of moderate to severe headache. 相似文献
995.
Barber JC Huang S Bateman MS Collins AL 《American journal of medical genetics. Part A》2011,(11):2807-2815
The central portion of the short arm of chromosome 5 is unusual in that large, cytogenetically visible interstitial deletions segregate in families with and without phenotypic consequences. Here we present a family in which a transmitted interstitial deletion of 5p13.3 to 5p14.3 co-segregated with learning and/or behavioral difficulties in six family members. Facial dysmorphism was not striking but a father and daughter both had lacrimal fistulae. The deletion was 12.23 Mb in size (chr5:20,352,535-32,825,775) and contained fifteen known protein coding genes. Five of these (GOLPH3; MTMR12; ZFR; SUB1; and NPR3) and an ultra-conserved microRNA (hsa-miR-579) were present in an 883 kb candidate gene region in 5p13.3 that was deleted in the present family but not in previously reported overlapping benign deletions. Members of the cadherin precursor gene cluster, with brain specific expression, were deleted in both affected and benign deletion families. The candidate genes in 5p13.3 may be sufficient to account for the consistent presence or absence of phenotype in medial 5p deletions. However, we consider the possibility of position effects in which CDH6, and/or other cadherin genes, become penetrant when adjacent genes, or modifiers of gene expression, are also deleted. This could account for the absence of intellectual disability in benign deletions of the cadherin cluster, the cognitive phenotype in medial 5p deletion syndrome and the greater severity of intellectual disability in patients with cri-du-chat syndrome and deletions of 5p15 that extend into the region deleted in the present family. 相似文献
996.
With the widespread clinical use of comparative genomic hybridization chromosomal microarray technology, several previously unidentified clinically significant submicroscopic chromosome abnormalities have been discovered. Specifically, there have been reports of clinically significant microduplications found in regions of known microdeletion syndromes. In general, these microduplications have distinct features from those described in the corresponding microdeletion syndromes. We present a 5½‐year‐old patient with normal growth, borderline normal IQ, borderline hypertelorism, and speech and language delay who was found to have a submicroscopic 2.3 Mb terminal duplication involving the two proposed Wolf–Hirschhorn syndrome (WHS) critical regions at chromosome 4p16.3. This duplication was the result of a maternally inherited reciprocal translocation involving the breakpoints 4p16.3 and 17q25.3. Our patient's features are distinct from those described in WHS and are not as severe as those described in partial trisomy 4p. There are two other patients in the medical literature with 4p16.3 microduplications of similar size also involving the WHS critical regions. Our patient shows clinical overlap with these two patients, although overall her features are milder than what has been previously described. Our patient's features expand the knowledge of the clinical phenotype of a 4p16.3 microduplication and highlight the need for further information about it. © 2011 Wiley‐Liss, Inc. 相似文献
997.
Yuna Seo Chul Jin Bo-Hyoung Jang Jin Pyeong Jeon Ye-Seul Lee Seung-Bo Yang Woo-Sang Jung Sang-Kwan Moon Ki-Ho Cho Seungwon Kwon 《Medicine》2021,100(31)
Rationale:Dopamine replacement is currently the standard treatment for restless leg syndrome (RLS); however, various adverse effects are associated with long-term therapy, and the benefits disappear upon discontinuation. To overcome these limitations, interest in traditional East Asian medicine has increased.Patient concerns:A 72-year-old Asian woman originally admitted for an intracerebral hemorrhage presented with complaints of an unpleasant sensation throughout the body that appeared at night.Diagnoses:The patient was diagnosed with chronic persistent RLS based on the 2012 Revised International Restless Leg Syndrome Study Group Diagnostic Criteria.Interventions:The patient was treated with extracts of the traditional herbal medicines Dangguijakyak-san (DS) and Shihogyeji-tang (ST). After 47 days of therapy, all herbal medicines were discontinued, and symptoms had not returned by the last follow-up 244 days after the initial treatment.Outcomes:One week after initiating herbal treatment with DS and ST, the RLS symptoms began to improve, and the total hours of sleep had increased from 2 to 9 hours by day 21, with a Korean version of the international restless legs scale score of 11 points. On day 36, ST was discontinued, given the continued improvement of symptoms. On day 47, symptoms had disappeared (Korean version of the international restless legs scale score: 0), and sleep disturbances caused by RLS had completely resolved. After day 47, DS was also discontinued. There were no adverse effects associated with the administration of DS and ST, and the symptoms had not recurred by the last follow-up on day 244.Lessons:In this case, RLS related symptoms, which had been present for approximately 60 years, were improved using only the traditional herbal medicines DS and ST (without dopamine replacement), and no symptoms recurred for 244 days. This case suggests that if replacement therapy is difficult or not desired, herbal medicinal therapies may be an effective alternative. This also suggests that the effect of herbal medicine on RLS might be semi-permanent. Further investigations, including clinical trials, are needed to confirm these effects. 相似文献
998.
An X Zhang AL Yang AW Lin L Wu D Guo X Shergis JL Thien FC Worsnop CJ Xue CC 《Respiratory medicine》2011,105(2):165-176
Ginseng alone or combined with other herbs has been increasingly used for chronic obstructive pulmonary disease (COPD). This review aims to evaluate the effectiveness and safety of oral Ginseng formulae for stable COPD. Four English databases and three Chinese databases were searched to identify randomized controlled trials. Methodological quality was assessed by Cochrane risk of bias and Jadad's scale. Data were analyzed using Review Manager 5.0. Twelve studies overall of low quality, involving 1560 participants were included. Results of three studies showed a mean difference (MD) of 0.30 (95%CI 0.02 to 0.58) for forced expiratory volume in 1 s (FEV(1)) improvement of Ginseng formulae versus placebo control. Findings of three studies revealed an MD of 9.43 (95%CI 3.64 to 15.21) of FEV(1) % predicted between Ginseng formulae and placebo control. Quality of life (Qol) measured by St. George's Respiratory Questionnaire was improved (MD -10.32, 95%CI -14.99 to -5.65) with Ginseng formulae plus pharmacotherapy versus pharmacotherapy alone in one study. There were no severe adverse events reported. Ginseng formulae for stable COPD patients show promising evidence of lung functions and Qol improvement. However, the degree of benefit is uncertain due to potential risk of bias of the included studies. 相似文献
999.
背景:目前采用骨科弹道式冲击波治疗软组织劳损较为普遍,但与中药熏洗配合治疗的报道甚少。
目的:观察骨科弹道式冲击波配合中药熏洗治疗软组织劳损的临床疗效。
方法:将912例软组织劳损患者采用骨科弹道式冲击波配合中药熏洗治疗。采用目测类比定级法评定患者痛点受压时的疼痛强度。
结果与结论:经骨科弹道式冲击波配合中药熏洗治疗1周后,患者疼痛下降明显,第2周时测类比定级法评分变化不明显。2周以后,患者疼痛强度与治疗前比较明显下降(P < 0.05)。跟痛症与网球肘、屈指肌腱腱鞘炎比较,患者疼痛强度下降缓慢(P < 0.05)。结果证实,骨科弹道式冲击波配合中药熏洗治疗软组织劳损疗效显著。 相似文献
1000.