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71.
Christoph Eisenbach Peter Sauer Arianeb Mehrabi Wolfgang Stremmel Jens Encke 《Clinical transplantation》2006,20(S17):111-116
Abstract: Liver transplantation for hepatitis B virus (HBV)-related liver disease has changed from a contraindication to outcomes comparable with non-HBV-related liver transplantations during the last two decades. Mainly the implementation of immunoprophylaxis with hepatitis B immunoglobulin (HBIG) and the use of nucleoside analogs such as lamivudine and adefovir account for this dramatic change. The standard of care in most centers today consists of lamivudine treatment in replicating hepatitis B pre-orthotopic liver transplantation (OLT) and a combination regimen of lamivudine and HBIG post-OLT. With adefovir, a potent antiviral drug became available in recent years that allows for the treatment of patients with lamivudine-resistant tyrosine-methionine-aspartate-aspartate (YMDD)-mutant HBV. In the transplantation setting, first studies indicate that a triple prophylactic therapy consisting of lamivudine, adefovir, and HBIG will become the standard of care for YMDD-mutant-related hepatitis B. With new drugs emerging for the treatment of chronic HBV, there is optimism for new options also in the transplant setting. 相似文献
72.
血清TBA评估慢性重型肝炎肝细胞损伤的临床价值 总被引:4,自引:0,他引:4
目的 进一步探讨血清总胆汁酸 (TBA)评估慢性重型肝炎患者肝细胞损伤程度及其预后的临床价值。方法 对慢性重型肝炎组 12 2例、慢性肝炎组 98例和正常对照组 4 8人同时测定TBA、总胆红素 (TBIL)及凝血酶原活动度 (PA) ,并分析它们之间的关系。结果 慢性重型肝炎患者血清TBA水平显著高于慢性肝炎组及正常对照组 (P <0 .0 1) ,TBA与TBIL呈正相关 ,与PA呈负相关 (分别为r =0 .712 ,P <0 .0 1;r =- 0 .832 ,P <0 .0 1) ;治愈 +好转组TBA明显低于恶化 +死亡组 (P <0 .0 1)。结论 慢性重型肝炎TBA显著升高 ,肝细胞损伤越严重 ,TBA水平越高。TBA是敏感的肝功能检测指标 ,对慢性重型肝炎的疗效及预后评估有一定的临床价值。 相似文献
73.
74.
Virological, biochemical and histological effects of human lymphoblastoid interferon in Swedish patients with chronic hepatitis C 总被引:1,自引:0,他引:1
J. A. Garson I. Uhnoo K. Whitby J. H. Braconier R. Deaville A. Duberg E. Wallmark J. Wiström R. D. Goldin B. Spacey 《Journal of viral hepatitis》1997,4(5):325-331
Thirty-eight Swedish patients with chronic hepatitis C were randomly assigned to receive either 3 million units (MU) or 5MU of human lymphoblastoid interferon-α-n1 (Wellferon) three times per week for either 6 or 12 months. The patients were monitored biochemically, histologically and by quantitative polymerase chain reaction for circulating HCV RNA, during therapy and for the following year. Overall, 22 (58%) of the patients lost detectable hepatitis C virus (HCV) viraemia during therapy but eight of these patients relapsed during follow-up, leaving 14 (37%) sustained responders. Patients infected with HCV non-type 1 genotypes were significantly more likely to achieve a sustained response than were those infected with HCV type 1 (63% vs 10.5%, P =0.001). Sustained virological responses were also associated with lower pretreatment viraemia level, younger age, absence of cirrhosis and the higher interferon dosage regimens but these associations failed to reach statistical significance. In 97% of patients there was concordance between virological and biochemical responses, and a statistically significant ( P =0.005) improvement in the Knodell histological activity index was observed in the virological sustained responders. 相似文献
75.
C. A. Gogos J. K. Starakis H. P. Bassaris A. T. Skoutelis 《Clinical microbiology and infection》2003,9(6):540-542
Abscess formation at the injection site is an unusual infectious complication of interferon- α (IFN- α ) treatment of chronic hepatitis C virus (HCV) infection, but remote abscess formation during IFN- α therapy is very rare. In the present communication, we report three cases of remote abscess formation detected among 68 patients with chronic viral hepatitis treated with IFN- α , and review the pertinent English literature. We believe that, as fever and constitutional symptoms are common side effects of IFN- α treatment, a high index of suspicion is indicated to exclude abscess formation in cases of unexplained fever during IFN- α therapy. 相似文献
76.
慢性HBV感染患者精子中HBVDNA存在研究的初步报告 总被引:1,自引:0,他引:1
用Southern Blot方法,我们研究了13份慢性HBV感染患者(8份慢迁旰,5份慢活肝)和2份对照精液标本中HBV DNA存在状况。提取物一半用限制酶HindⅢ消化,各行琼脂电泳,转移到纤维膜上,然后用~(32)P—HBV—DNA探针分子杂交。在4份精子內检出HBV DNA,3份为游离形式,1份为整合形式。结果表明HBV DNA可以存在精于内,游离状态HBV DNA提示有传染性、整合序列HBV DNA的存在提示有通过生殖细胞遗传的可能。 相似文献
77.
78.
Florence Lacaille Herv Zylberberg Herv Hagge Brigitte Roualds Christian Meyrignac Michel Chousterman Robert Girot 《Liver international》1998,18(1):49-51
ABSTRACT— Hepatitis C is frequently associated with immune-mediated diseases, such as cryoglobulinemia. Guillain-Barré syndrome is an acute demyelinating neuropathy of probable immune pathogenesis. We describe two patients with Guillain-Barré syndrome, and associated chronic hepatitis C, the second one previously treated with interferon. The link between both conditions may be hepatitis C being the trigger of this immune polyneuropathy. Guillain-Barré syndrome should be added to the list of conditions associated with hepatitis C. 相似文献
79.
乙型肝炎肝内血管病变免疫组织化学观察 总被引:2,自引:0,他引:2
目的 研究乙型肝炎(乙肝)肝内血管病变与肝病变的关系。方法 270例肝活检标本取自住院乙肝患者,选择10例大致正常肝组织作对照。石蜡包埋,4μm切片,除依次作HE、弹力、网状及胶原杂色外另用特异性平滑肌肌动蛋白单克隆抗生进行免疫组织化学标记,结果 正常肝组织α-SMA仅在原有的肝内动、静脉及胆管壁表达。乙肝病变较轻组肝组织α-SMA示阳必表达占75%;乙肝病变较重及肝硬变组肝组织α-SMA示强阳性 相似文献
80.
活血祛风法治疗慢性活动性乙型肝炎临床观察 总被引:5,自引:1,他引:4
用活血祛风法治疗反复发作的慢性活动性乙型肝炎70例,总有效为95.7%,对照组65例健脾清热利湿法治疗,总有效率为78。5%(P<0.05).治疗组抗LSP,LMA,抗核抗体,类风湿因子阴转率,HBeAg,抗HBcIgM,HBV-DNA阴转率,抗HBe阳转率均优于对照组(P<0.001)。 相似文献