全文获取类型
收费全文 | 543篇 |
免费 | 20篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 9篇 |
妇产科学 | 4篇 |
基础医学 | 36篇 |
口腔科学 | 26篇 |
临床医学 | 40篇 |
内科学 | 15篇 |
皮肤病学 | 7篇 |
神经病学 | 165篇 |
特种医学 | 9篇 |
外科学 | 48篇 |
综合类 | 97篇 |
预防医学 | 10篇 |
眼科学 | 30篇 |
药学 | 28篇 |
中国医学 | 39篇 |
肿瘤学 | 3篇 |
出版年
2024年 | 2篇 |
2023年 | 4篇 |
2022年 | 11篇 |
2021年 | 36篇 |
2020年 | 17篇 |
2019年 | 14篇 |
2018年 | 10篇 |
2017年 | 11篇 |
2016年 | 19篇 |
2015年 | 15篇 |
2014年 | 32篇 |
2013年 | 26篇 |
2012年 | 28篇 |
2011年 | 31篇 |
2010年 | 34篇 |
2009年 | 27篇 |
2008年 | 23篇 |
2007年 | 29篇 |
2006年 | 18篇 |
2005年 | 28篇 |
2004年 | 13篇 |
2003年 | 16篇 |
2002年 | 18篇 |
2001年 | 18篇 |
2000年 | 8篇 |
1999年 | 6篇 |
1998年 | 12篇 |
1997年 | 4篇 |
1996年 | 7篇 |
1995年 | 9篇 |
1994年 | 2篇 |
1993年 | 13篇 |
1992年 | 7篇 |
1991年 | 6篇 |
1990年 | 2篇 |
1989年 | 4篇 |
1988年 | 3篇 |
1986年 | 4篇 |
1984年 | 3篇 |
1983年 | 1篇 |
1982年 | 4篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1976年 | 1篇 |
排序方式: 共有579条查询结果,搜索用时 15 毫秒
1.
2.
Facial muscle spasms, which are rare in adults, present a particularly difficult entity for the optometrist to recognise. The condition may not even manifest itself at an eye examination and the optometrist may have to rely on subjective symptoms to assist in the recognition of the condition. It is important to diagnose the condition correctly as specific and effective treatment is available. 相似文献
3.
Hans C. Andersson Dilys M. Parry John J. Mulvihill 《American journal of medical genetics. Part A》1995,56(1):72-75
Hereditary lymphedemas that are not associated with other malformations usually affect the lower limbs and are inherited in an autosomal dominant fashion. These non-syndromic hereditary lymphedemas are categorized by their age of onset, being either congenital (Milroy disease) or having an onset in childhood or around puberty (Meige disease). We describe a family in which three individuals in three generations had unusually late onset of lym-phedema in their mid-twenties or thirties. The proband additionally developed a very rare lymphangiosarcoma. This tumor, usually associated with post-mastectomy lym-phedema, has not been described in late-onset hereditary lymphedema. Because of an unusually high incidence of multiple primary tumors in association with lymphangiosarcoma in the literature (approximately 10%) and the proband's own familial cancer background, we speculate that an inherited predisposition to malignancy may underlie the development of lymphedema-associated lymphangiosarcoma. © 1995 Wiley-Liss, Inc. 相似文献
4.
压力调节容量控制通气对肺损伤犬血流动力学、呼吸力学和呼吸功能的影响 总被引:4,自引:0,他引:4
目的 探讨压力调节容量控制(PRVC)通气模式对健康及急性肺损伤(ALI)模型犬的血流动力学、呼吸力学和呼吸功能的影响。方法 PRVC和间歇正压通气(IPPV)两种通气模式在呼气末压为0、0.5、1.0和1.5kPa时,分别测定健康犬及油酸诱发ALI犬的血流动力学、呼吸力学及血气参数。结果 健康犬PRVC较IPPV模式下除了在PEEP为0.5kPa时,气道峰压(PIP)、肺动态顺应性(Cdyn)和肺血管阻力(PVR)的影响差异有显著性,对血流动力学、呼吸力学及呼吸功能的影响差异均无显著性。ALI犬PRVC较IPPV模式下各PEEP水平的PIP、平均气道压(mPaw)、Cdyn、动脉血氧分压[pa(O2)]和氧耗(VO2)的影响均有显著意义,但两种通气模式对血流动力学的影响差异无显著性。结论 与IPPV相比,PRVC通气模式能降低PIP,增加Cdyn和提高pa(O2),两模式对血流动力学的影响差异无显著性,PRVC更适用于ALI/ARDS的治疗。 相似文献
5.
Bradley J Katz John R Burroughs Richard L Anderson Shannon Bownds John D McCann 《Movement disorders》2007,22(2):231-234
We present a patient with a facial movement disorder that has characteristics of both blepharospasm and bilateral asynchronous hemifacial spasm. Because of the increased incidence of blepharospasm in patients with hemifacial spasm, our patient's clinical presentation is probably not a chance occurrence, but rather a manifestation of some predisposition for these two movement disorders. This unusual constellation of signs and symptoms challenges the current diagnostic criteria and suggests that some of these facial movement disorders may lie on a spectrum, rather than represent distinct entities. 相似文献
6.
Microvascular decompression for hemifacial spasm: postoperative neurologic follow-up and evaluation of life quality 总被引:2,自引:0,他引:2
K. Heuser E. Kerty P. K. Eide M. Cvancarova E. Dietrichs 《European journal of neurology》2007,14(3):335-340
Microvascular decompression (MVD) is an effective and safe treatment in hemifacial spasm (HFS). Postoperative evaluations are usually made by neurosurgeons. Follow-up studies performed by neurologists and postoperative quality of life (QoL) investigations are lacking. All 25 HFS patients operated with MVD in our centre between 2000 and 2004 were evaluated with the recently validated HFS-7 scheme, extended with the item 'sleep disturbance due to HFS' (HFS-8). The patients underwent a careful neurological examination median 3 years after the operation. The evaluation focused on clinical aspects, changes in blood pressure and time until observable effect of MVD. The evaluation of HFS-7 questionnaire and the extended form (HFS-8) showed significant improvement in QoL after MVD. Neurological outcome was in almost all cases excellent or good. Eleven (44%) patients had no neurological deficits at all. Only one patient had serious complications with ipsilateral facial palsy, deafness, balance problems and vertigo. The other patients had minor neurological findings or symptoms. Eighteen (72%) patients experienced early effect within 3 months after MVD; seven (28%) patients had late effect between 6 and 14 months. Median age of the patients with late effect (62.6 years) was significantly higher than in those with early effect (52.7 years). 相似文献
7.
目的:分析43例肺性脑病与多器官功能障碍的关系,以便早期采取预见性防治措施。方法:把43例肺性脑病时伴发的功能障碍器官个数与死亡率的关系及酸碱、电解质测定进行统计列表分析,结果:肺性脑病100%并发器官功能障碍,最常受损器官:肺、心、脑、肝或肾,受损器官数目越多,病情越严重,肺性脑病时,呼酸代酸,低钠,低氯血症明显增多。结论:肺性脑病100%伴发多器官功能障碍,随功能障碍器官数目的增加,死亡率亦增加,酸碱失衡及电解质紊乱与多器官功能障碍有关。 相似文献
8.
Celia I. Kaye Alice O. Martin Beverly R. Rollnick R. Rollnick Konrad Nagatoshi Jeannette Israel Mark Hermanoff Brad Tropea Joan T. Richtsmeier Newton E. Morton 《American journal of medical genetics. Part A》1992,43(6):913-917
Seventy-four families of probands with oculoauriculovertebral anomaly were evaluated, including 116 parents and 195 off-spring. Relatives were examined to identify ear malformations, mandibular anomalies, and other craniofacial abnormalities. For segregation analysis using POINTER, selection of the sample was consistent with single as-certainment. Different population liabilities were used for probands and relatives, because affection was narrowly defined for probands and broadly defined for relatives. The hypothesis of no genetic transmission was rejected. The evidence favored autosomal dominant inheritance; recessive and polygenic models were not distinguishable. © 1992 Wiley-Liss, Inc. 相似文献
9.
On a group level, satisfaction with botulinum neurotoxin (BoNT) treatment in neurological indications is high. However, it is well known that a relevant amount of patients may not respond as expected. The aim of this study is to evaluate the BoNT treatment outcome on an individual level using a statistical single-case analysis as an adjunct to traditional group statistics. The course of the daily perceived severity of symptoms across a BoNT cycle was analyzed in 20 cervical dystonia (CD) and 15 hemifacial spasm (HFS) patients. A parametric single-case autoregressive integrated moving average (ARIMA) time series analysis was used to detect individual responsiveness to BoNT treatment. Overall, both CD and HFS patients significantly responded to BoNT treatment with a gradual worsening of symptom intensities towards BoNT reinjection. However, only 8/20 CD patients (40%) and 5/15 HFS patients (33.3%) displayed the expected U-shaped curve of BoNT efficacy across a single treatment cycle. CD (but not HFS) patients who followed the expected outcome course had longer BoNT injection intervals, showed a better match to objective symptom assessments, and were characterized by a stronger certainty to control their somatic symptoms (i.e., internal medical locus of control). In addition to standard evaluation procedures, patients should be identified who do not follow the mean course-of-treatment effect. Thus, the ARIMA single-case time series analysis seems to be an appropriate addition to clinical treatment studies in order to detect individual courses of subjective symptom intensities. 相似文献
10.
目的:对糖尿病肾病(DN)不同阶段的中医证候特点及证候分布规律进行分析探讨。方法:对我院内分泌科住院的DN患者162人按照III、IV、V期进行分组,对不同分期的证候分布特点进行比较分析。结果:III期主要以气阴两虚为主,偶可见血瘀证。IV期病情出现复杂表现,主要以阴阳两虚为主,血瘀证表现相对明显。V期阴阳两虚明显,虚实错综复杂,血瘀证明显加重。结论:糖尿病肾病不同时期有不同的证候特点,其本质是虚实夹杂证,从III期气阴两虚开始,阴损及阳,最后发展为V期的阳虚,血瘀作为主要的兼证贯穿DN的整个病程。 相似文献