全文获取类型
收费全文 | 8005篇 |
免费 | 859篇 |
国内免费 | 537篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 15篇 |
妇产科学 | 13篇 |
基础医学 | 173篇 |
口腔科学 | 38篇 |
临床医学 | 285篇 |
内科学 | 257篇 |
皮肤病学 | 42篇 |
神经病学 | 64篇 |
特种医学 | 152篇 |
外科学 | 102篇 |
综合类 | 1569篇 |
预防医学 | 243篇 |
眼科学 | 43篇 |
药学 | 4654篇 |
7篇 | |
中国医学 | 1651篇 |
肿瘤学 | 80篇 |
出版年
2024年 | 28篇 |
2023年 | 76篇 |
2022年 | 189篇 |
2021年 | 259篇 |
2020年 | 253篇 |
2019年 | 145篇 |
2018年 | 174篇 |
2017年 | 247篇 |
2016年 | 315篇 |
2015年 | 309篇 |
2014年 | 764篇 |
2013年 | 617篇 |
2012年 | 789篇 |
2011年 | 747篇 |
2010年 | 562篇 |
2009年 | 508篇 |
2008年 | 501篇 |
2007年 | 557篇 |
2006年 | 456篇 |
2005年 | 390篇 |
2004年 | 293篇 |
2003年 | 215篇 |
2002年 | 165篇 |
2001年 | 148篇 |
2000年 | 135篇 |
1999年 | 106篇 |
1998年 | 66篇 |
1997年 | 58篇 |
1996年 | 37篇 |
1995年 | 45篇 |
1994年 | 36篇 |
1993年 | 20篇 |
1992年 | 23篇 |
1991年 | 14篇 |
1990年 | 11篇 |
1989年 | 22篇 |
1988年 | 24篇 |
1987年 | 22篇 |
1986年 | 20篇 |
1985年 | 7篇 |
1984年 | 9篇 |
1983年 | 5篇 |
1982年 | 5篇 |
1981年 | 4篇 |
1980年 | 7篇 |
1979年 | 7篇 |
1977年 | 3篇 |
1975年 | 2篇 |
1974年 | 2篇 |
1971年 | 1篇 |
排序方式: 共有9401条查询结果,搜索用时 31 毫秒
951.
Sangeetha Shanmugasundaram N. Manjunatha R. Vijayan R. B. Khatwal M. K. Samanta 《Indian journal of pharmaceutical sciences》2011,73(6):649-655
The aim of the study was to formulate and investigate the pharmacokinetic parameters for the tablets of herbal extract of caffeine with comparison to synthetic formulation. The tablets of the aqueous herbal extract of leaves of Camellia sinensis and synthetic caffeine were formulated by wet granulation technique. The HPLC and HPTLC were applied as analytical tools for estimation of caffeine. The batches of formulation (B1 to B7) were subjected for various pre and post-formulation studies. The pharmacokinetic of the batch B5 was assessed in rabbits, and the results were compared to synthetic batch B7. With the suitable pre and post-formulation results, the B5 showed in vitro release of 90.54% of caffeine at the end of 60 min. The release followed first order kinetics and the plot of Higuchi and Peppas confirms anomalous diffusion as the basic mechanism behind the release. B5 revealed non-significant mean Cmax, t1/2, and AUC of 1.88 μg/ml, 5.52 h and 9.67 μg.h/ml respectively compared to B7. The study highlights; no significant difference in the pharmacological effect of caffeine when administered in the form of extract. The administration of herbal extract can further provide the other health benefits lacked by synthetic caffeine. 相似文献
952.
Hae-In LeeMi-Su Kim Kyung-Mi LeeSeok-Kyu Park Kwon-Il SeoHye-Jin Kim Myung-Joo KimMyung-Sook Choi Mi-Kyung Lee 《Food and chemical toxicology》2011,49(9):2370-2376
The potential health benefits of tea have long been studied. This study examined the role of powdered sea buckthorn leaf tea (SLT) in high-fat diet-induced obese mice. The mice were fed two different doses of SLT (1% and 5%, wt/wt) for six weeks. SLT suppressed body weight gain in a dose-dependent manner and significantly reduced visceral fat, plasma levels of leptin, triglyceride and total cholesterol and ALT activity compared with the high-fat-fed control mice. SLT also decreased hepatic triglyceride and cholesterol concentrations and lipid accumulation, whereas elevated fecal lipid excretion. High-fat feeding resulted in simultaneously decreasing hepatic FAS and G6PD activities and increasing PAP, β-oxidation and CPT activities. However, SLT supplementation during high-fat feeding led to a significant decrease in PAP, β-oxidation and CPT activities with a simultaneous increase in G6PD activity. The hepatic CYP2E1 activity and hepatic and erythrocyte lipid peroxides were significantly lowered with SLT supplements. Hepatic and erythrocyte SOD and CAT activities were also increased with SLT supplements in a dose-dependent manner, whereas GSH-Px activity was increased in erythrocytes only. These results indicate that SLT has potential anti-visceral obesity and antioxidant effects mediated by the regulation of lipid and antioxidant metabolism in high-fat diet-induced obese mice. 相似文献
953.
Farhan AlHusbanYvonne Perrie Afzal R. Mohammed 《European journal of pharmaceutics and biopharmaceutics》2011,79(3):627-634
The current study aimed to exploit the electrostatic associative interaction between carrageenan and gelatin to optimise a formulation of lyophilised orally disintegrating tablets (ODTs) suitable for multiparticulate delivery. A central composite face centred (CCF) design was applied to study the influence of formulation variables (gelatin, carrageenan and alanine concentrations) on the crucial responses of the formulation (disintegration time, hardness, viscosity and pH). The disintegration time and viscosity were controlled by the associative interaction between gelatin and carrageenan upon hydration which forms a strong complex that increases the viscosity of the stock solution and forms tablet with higher resistant to disintegration in aqueous medium. Therefore, the levels of carrageenan, gelatin and their interaction in the formulation were the significant factors. In terms of hardness, increasing gelatin and alanine concentration was the most effective way to improve tablet hardness. Accordingly, optimum concentrations of these excipients were needed to find the best balance that fulfilled all formulation requirements. The revised model showed high degree of predictability and optimisation reliability and therefore was successful in developing an ODT formulation with optimised properties that were able deliver enteric coated multiparticulates of omeprazole without compromising their functionality. 相似文献
954.
Susanne Halken Lone Agertoft Jürgen Seidenberg Carl‐Peter Bauer François Payot Maria Flora Martin‐Muñoz Małgorzata Bartkowiak‐Emeryk Andrea Vereda Stephanie Jean‐Alphonse Michel Melac Martine Le Gall Ulrich Wahn 《Pediatric allergy and immunology》2010,21(6):970-976
Halken S, Agertoft L, Seidenberg J, Bauer C‐P, Payot F, Martin‐Muñoz MF, Bartkowiak‐Emeryk M, Vereda A, Jean‐Alphonse S, Melac M, Le Gall M, Wahn U. Five‐grass pollen 300IR SLIT tablets: efficacy and safety in children and adolescents.Pediatr Allergy Immunol 2010: 21: 970–976.© 2010 John Wiley & Sons A/S The efficacy and safety of five‐grass pollen 300IR sublingual immunotherapy (SLIT) tablets (Stallergènes SA, France) have previously been demonstrated in paediatric patients. This report presents additional data concerning efficacy at pollen peak, efficacy and safety according to age, nasal and ocular symptoms, use of rescue medication, satisfaction with treatment and compliance. Children (5–11 yr) and adolescents (12–17 yr) with grass pollen–allergic rhinoconjunctivitis were included in a multinational, randomized, double‐blind, placebo‐controlled study and received either a 300IR five‐grass pollen tablet or placebo daily in a pre‐ (4 months) and co‐seasonal protocol. The severity of six symptoms (sneezing, rhinorrhoea, nasal congestion, nasal and ocular pruritis, and tearing) was scored, and rescue medication use was recorded daily during the pollen season. Patient satisfaction was recorded at the season end. A total of 161 children and 117 adolescents were evaluated (n = 267). 300IR SLIT was effective over the whole season (p = 0.0010) and at the pollen peak (p = 0.0009). The adjusted mean difference between 300IR and placebo groups was significant for both nasal (p = 0.0183) and ocular (p < 0.0001) symptoms. Rescue medication use was statistically lower in the SLIT group during the pollen season and at the pollen peak (both p < 0.05). More patients in the SLIT group were satisfied with their treatment compared to placebo (83.2% vs. 68.1%, p = 0.0030), and compliance was high (SLIT 93.9% of patients were compliant, placebo 94.8% of patients were compliant). SLIT was well tolerated by children and adolescents. 300IR five‐grass pollen tablets are effective and safe during the pollen season and at the pollen peak in children and adolescents with grass pollen rhinoconjunctivitis. 相似文献
955.
目的观察奥美拉唑联合铝碳酸铁片治疗十二指肠球后溃疡的临床疗效及不良反应。方法将56例十二指肠球后溃疡患者随机分为两组,对照组28例仅采用奥美拉唑治疗;治疗组28例在对照组治疗基础上加用铝碳酸镁片,两组疗程均为4周。观察两组患者临床症状、胃镜及药物不良反应变化。结果治疗组治疗总有效率(92.9%)明显优于对照组(82.1%)(P〈0.05);治疗组溃疡愈合率(82.1%)明显优于时照组(71.4%)(P〈0.05);两组治疗期间均未出现明显不良反应。结论奥美拉唑联合铝碳酸镁片治疗能明显改善十二指肠球后溃疡患者的临床症状,促进溃疡愈合,且无严重不良反应。 相似文献
956.
曲马多骨架缓释片的研究 总被引:5,自引:0,他引:5
曲马多骨架缓释片采用氢化植物油,羟丙甲纤维素等辅料压制而在。体外释放度实验中,8h累积释放量大于75%,其释放行为符合Higuchi方程。本品在加速稳定性实验条件下较为稳定。 相似文献
957.
张邦升 《中国现代药物应用》2012,6(13):8-9
目的探讨不同用药方案治疗椎-基底动脉供血不足性眩晕的疗效及成本效果。方法将120例椎-基底动脉供血不足性眩晕患者随机分为眩晕宁组(A组:治疗组40例)、氟桂利嗪组(B组:观察组39例)及尼莫地平合用复方丹参片组(C组:对照组41例),60d后观察3组患者临床疗疗效。结果 A组总有效率为95.0%。B总有效率为84.6%,C总有效率为总有效率为73.2%。3组相比,具有显著性差异。结论眩晕宁(A组)是治疗椎-基底动脉供血不足性眩晕的最佳方案。 相似文献
958.
目的 筛选氧氟沙星片最佳处方和制备工艺。方法 采用正交试验法考察羧甲基淀粉钠 (CMS Na)、十二烷基硫酸钠(SDS)的用量和制片压力对氧氟沙星片的质量影响。结果 制备的氧氟沙星片各项指标符合规定 ,5min溶出度 >80 %。结论 本法处方合理 ,工艺简单 ,适用于工业化生产 相似文献
959.
Understanding drivers of success for alien species can inform on potential future invasions. Recent conceptual advances highlight that species may achieve invasiveness via performance along at least three distinct dimensions: 1) local abundance, 2) geographic range size, and 3) habitat breadth in naturalized distributions. Associations among these dimensions and the factors that determine success in each have yet to be assessed at large geographic scales. Here, we combine data from over one million vegetation plots covering the extent of Europe and its habitat diversity with databases on species’ distributions, traits, and historical origins to provide a comprehensive assessment of invasiveness dimensions for the European alien seed plant flora. Invasiveness dimensions are linked in alien distributions, leading to a continuum from overall poor invaders to super invaders—abundant, widespread aliens that invade diverse habitats. This pattern echoes relationships among analogous dimensions measured for native European species. Success along invasiveness dimensions was associated with details of alien species’ introduction histories: earlier introduction dates were positively associated with all three dimensions, and consistent with theory-based expectations, species originating from other continents, particularly acquisitive growth strategists, were among the most successful invaders in Europe. Despite general correlations among invasiveness dimensions, we identified habitats and traits associated with atypical patterns of success in only one or two dimensions—for example, the role of disturbed habitats in facilitating widespread specialists. We conclude that considering invasiveness within a multidimensional framework can provide insights into invasion processes while also informing general understanding of the dynamics of species distributions.Human socioeconomic activities are altering species’ global distributions, bridging natural dispersal barriers through the accidental and intentional relocation of organisms, and opening opportunities for them to expand into new regions beyond their historic native ranges (1). The outcome of any given introduction event, however, is dependent on ecological and stochastic processes, and many introduced alien species fail to establish and persist (2, 3). Even species that do achieve persistent, self-sustaining populations (i.e., become naturalized sensu ref. 4) show varying degrees of success (i.e., invasiveness) in newly occupied regions. This has been true for natural colonization events throughout Earth’s history [e.g., on islands (5, 6) and during continental biotic interchanges (7–9)] and is certainly the case for the ongoing surge of human-mediated introductions (10–12). Disentangling the factors that lead to invasion success provides an opportunity not only for anticipating and mediating future anthropogenic invasions but also for better understanding the dynamics underlying natural range expansions (13).Quantifying a species’ success in invading the alien range is complex, a fact reflected in the diverse criteria applied by different authorities when deciding whether or not to classify naturalized species as invasive (14). Recent efforts have therefore recognized that invasiveness cannot be captured by a single metric but rather encompasses multiple aspects of ecological success and impact (15, 16). Some proposed metrics, such as spread rate and socioeconomic impacts, are difficult to quantify for large numbers of species (4, 17). However, Rabinowitz’s three-dimensional scheme for characterizing the rarity or commonness of species in their native distributions (18, 19) has been successfully co-opted as a valuable perspective for better understanding the success of alien species (16, 20, 21). Applied in the context of introduced species, this framework recognizes the potential for established aliens to vary along at least three demographic dimensions of invasiveness: 1) in local abundance within the naturalized range, 2) in geographic range size or extent of the naturalized range, and 3) in habitat breadth in the naturalized range (16). We subsequently distinguish these metrics as dimensions of invasiveness when measured in the naturalized distributions of alien species and dimensions of commonness when measured in species native distributions.Considering invasiveness within a multidimensional framework is particularly important if species vary independently among different dimensions (16, 21). Such a scenario opens the possibility for aliens to achieve invasion success in many different ways (Fig. 1). In other words, there could exist different forms of invasiveness, similar to the different forms of rarity or commonness originally proposed by Rabinowitz (19). On the other hand, theoretical concepts and empirical examples suggest correlations between Rabinowitz’s dimensions of commonness among species in their native distributions (6, 22, 23). For example, a positive relationship between local abundance and extent of geographic occurrence or range size has been documented at various scales for numerous taxa (24–26), including plants (24, 27–31), with niche breadth proposed as a linking mechanism (24, 26, 32). If the processes that generate these patterns in native distributions act similarly in species alien distributions, some of the forms of invasiveness outlined in Fig. 1 should be less likely to occur than others. More specifically, if the invasiveness dimensions are correlated, species should vary from excelling (abundant, widespread, generalists; form AWG in Fig. 1) to performing poorly (scarce, restricted, specialists; form 0 in Fig. 1) in all three invasiveness dimensions (33). On the other hand, these macroecological patterns are not without exception, and a recent assessment found little support for correlations among commonness dimensions in Europe’s native flora (34). Alien distributions may further differ because aliens vary in their residence time, and particularly recently introduced species may be in disequilibrium and still increasing along one or more of the invasiveness dimensions (21, 35–37). In line with these alternatives, a continuum from overall poor invaders to species succeeding in all three dimensions has been documented for the regional alien flora of French grassland communities (20), while associations among dimensions were found to be low for the herbaceous alien flora of Southeast Australia (16). The correspondence among different invasiveness dimensions at broader geographic scales has yet to be assessed.Open in a separate windowFig. 1.Conceptual diagram outlining the eight different forms of invasiveness depending on success in zero, one, two, or three dimensions of invasiveness (based on refs. 16, 18, and 20). Forms of invasiveness within the cyan polygon are associated with high naturalized abundance, within the magenta polygon with widespread naturalized geographic extent, and within the yellow polygon with high naturalized habitat breadth. The overlap between magenta and cyan is blue, between cyan and yellow is green, between magenta and yellow is red, and between all three is black. The forms of invasiveness are comparable to analogous forms of commonness used to describe species in their native distributions, and we refer to the same abbreviations in both cases.Functional traits play a role in mediating invasion processes, but efforts to identify characteristics of successful invaders have generally resulted in few or inconsistent associations (38, 39). However, distinguishing between different components of invasiveness may provide additional clarity if each is influenced by different traits or if the same trait has contrasting effects on different dimensions (15, 16, 21, 40, 41). For example, many plant traits are associated with general trade-offs between rapid growth (i.e., acquisitive growth strategies) versus stress tolerance and survival (i.e., conservative growth strategies) (42–44), and one can hypothesize scenarios where these divergent strategies are associated with success in different dimensions of invasiveness (40, 41). Another example are specialized adaptations for long-distance dispersal that may promote rapid range expansion, both in extent and into new habitats, but likely do not provide any advantages that would influence local abundances (45, 46). For habitat specialists, their specific habitat associations may additionally be important for determining whether or not they become widespread (31).A number of hypotheses for invasion success additionally emphasizes the importance of unique ecological dynamics that emerge when species are decoupled from constraints experienced in their native environments (47). For example, because species are able to occupy unfilled niches where introduced [i.e., Darwin’s naturalization hypothesis (48, 49)] or because they leave behind important herbivores, competitors, or pathogens that limit populations in the native distribution [i.e., enemy release (50, 51)]. These mechanisms may be less likely when species expand into areas near the native range, for example, during natural range expansions or intracontinental introductions, as the alien individuals are more likely to encounter conditions similar to those that limited their native distribution compared to species introduced from further abroad (e.g., those with extracontinental origins) (52–54).Here, we combine vegetation plot data covering Europe (55) with databases of alien and native distributions (56, 57), plant traits (58, 59), and historical dates of introduction (60) to provide a comprehensive assessment of multidimensional invasion success for the European alien seed plant flora. First, we test for correlations among local abundance, geographic extent, and habitat breadth of alien species in their naturalized distributions and classify species into one of the eight forms of invasiveness (Fig. 1). We ask whether some forms of invasiveness rarely occur and specifically whether species tend to fit along a continuum ranging from generally poor invaders to super invaders—species excelling in all three dimensions. In addition, we compare relationships among dimensions of invasiveness to those among dimensions of commonness measured for Europe’s native flora, assessing similarities and differences in patterns of distribution between contexts. Next, we explore likely drivers of each invasiveness dimension, testing whether the year of first alien occurrence in Europe, functional traits related to ecological strategies, specialized adaptations for long-distance dispersal, habitat associations, and region of origin explain different forms of invasion success. 相似文献
960.
本文利用PAR比色法测定了硫酸锌片兔体内药代动力学参数。本法操作简便、快速、准确、重现性好。本法回收率为93.3±2.2%,日内变异系数2.3%,日间变异系数2.4%,线性范围0.08~0.72μg/ml(r=0.9999,n=5)。 相似文献