中蒙医药结合治疗外阴白斑50例疗效分析

目的:观察女性外阴白色病变用中蒙药结合的治疗效果.方法:采用中药汤剂、散剂内服；中药粗粉剂冲泡外洗；蒙药制成膏剂外敷；阴道放药等综合治疗方法,对女性外阴白色病变进行治疗观察.结果:治疗50例,痊愈20例,显效23例,有效5例,无效2例.结论:采用中蒙药结合,内外同治的综合方法治疗女性外阴白色病变,疗效满意.     

Impaired cerebral vasoreactivity in white coat hypertensive adolescents

Background and purpose: Although its incidence is not high, adolescent hypertension may predict hypertension and increased cardiovascular risk in adulthood. Therefore, the aim of the present study was to assess whether cerebrovascular reactivity is altered in adolescent white coat and sustained hypertensive patients compared to healthy teenagers. Methods: Fifty‐nine normotensive, 47 white coat hypertensive (WCH), and 73 sustained hypertensive (SH) adolescents were studied. WCH and SH were differentiated by ambulatory blood pressure monitoring. Cerebrovascular reactivity was assessed by transcranial Doppler breath‐holding test and was expressed in percent (%) change to the resting cerebral blood flow velocity value. Results: The percent increase in middle cerebral artery mean blood flow velocity after 30 s of breath holding was lower in both WCH (5.3 ± 3.1%) and SH (9.5 ± 2.6%) groups indicating lower vasodilatory reactivity compared to healthy adolescents (12.1 ± 2.2%). Additionally, serum nitric oxide (NOx) concentrations were lower in both WCH (30.6 ± 11 μM) and SH (30.7 ± 22.4 μM) groups compared to controls (38.8 ± 7.6 μM). Conclusions: Both white coat and sustained hypertension result in decreased vasodilatory reaction to CO₂ in adolescents, suggesting involvement of the cerebral arterioles. The present study underlines the importance of early recognition and proper treatment of adolescent hypertension in order to prevent long‐term cardiovascular complications.     

运动应激试验前后血清皮质醇和IL-6水平与白大衣性高血压的关系

目的探讨运动应激试验前后血清皮质醇和IL-6水平的变化及其与白大衣性高血压的关系。方法选取2014年1月至2016年8月该院收治的白大衣性高血压患者48例作为研究组,选取同期普通高血压患者30例作为普通组和30例健康体检者作为对照组。3组均在空腹状态,在功率200 W的自行车上以蹬车2min后间歇5min再重复运动直至极度疲劳,完成运动应激试验。检测比较3组运动前、运动后即刻及运动后3h的血清皮质醇和IL-6水平及平均动脉压(MAP),分析血清皮质醇和IL-6水平对白大衣性高血压的诊断价值及其与患者MAP的关系。结果与对照组比较,研究组和普通组运动前后的血清皮质醇和IL-6水平及MAP均升高;与普通组比较,研究组运动前后的血清皮质醇和IL-6水平及MAP均升高(P0.05)。研究组运动后即刻及运动后3h的血清皮质醇和IL-6水平及MAP均较运动前升高(P0.05)。ROC曲线分析结果显示,运动应激试验前后血清皮质醇和IL-6水平对白大衣性高血压的诊断价值良好,其中以运动后即刻血清皮质醇和IL-6水平联合诊断白大衣性高血压的价值最优。Pearson线性相关分析结果显示,运动应激试验前后血清皮质醇和IL-6水平与白大衣性高血压MAP均呈正相关(r分别为0.844、0.802,P0.05)。结论运动应激试验前后血清皮质醇和IL-6水平对白大衣性高血压的诊断价值良好且与其血压水平相关,可能作为白大衣性高血压诊断和病情评估的参考指标。     

The total number of white matter interstitial neurons in the human brain

In the adult human brain, the interstitial neurons (WMIN) of the subcortical white matter are the surviving remnants of the fetal subplate zone. It has been suggested that they perform certain important functions and may be involved in the pathogenesis of several neurological and psychiatric disorders. However, many important features of this class of human cortical neurons remain insufficiently explored. In this study, we analyzed the total number, and regional and topological distribution of WMIN in the adult human subcortical white matter, using a combined immunocytochemical (NeuN) and stereological approaches. We found that the average number of WMIN in 1 mm³ of the subcortical white matter is 1.230 ± 549, which translates to the average total number of 593 811 183.6 ± 264 849 443.35 of WMIN in the entire subcortical telencephalic white matter. While there were no significant differences in their regional distribution, the lowest number of WMIN has been consistently observed in the limbic cortex, and the highest number in the frontal cortex. With respect to their topological distribution, the WMIN were consistently more numerous within gyral crowns, less numerous along gyral walls and least numerous at the bottom of cortical sulci (where they occupy a narrow and compact zone below the cortical‐white matter border). The topological location of WMIN is also significantly correlated with their morphology: pyramidal and multipolar forms are the most numerous within gyral crowns, whereas bipolar forms predominate at the bottom of cortical sulci. Our results indicate that WMIN represent substantial neuronal population in the adult human cerebral cortex (e.g. more numerous than thalamic or basal ganglia neurons) and thus deserve more detailed morphological and functional investigations in the future.     

Knowledge about the impact of age on fertility: a brief review

Delayed childbearing is currently a major challenge in reproductive medicine as increased age has an important impact on successful conception, both in natural and in assisted reproduction. There is a lack of knowledge about the impact of age on fertility, even in highly educated populations. A number of initiatives have been taken to increase fertility awareness. Health care providers have been encouraged to talk with patients about their reproductive life plan (RLP) for almost a decade based on recommendations from the Centres for Disease Control and Prevention. This concept has been explored successfully in Swedish contraception counselling. A growing number of online interventions aim to raise fertility awareness. These websites or interactive tools provide relevant information for individuals and couples as they consider whether they want children, when they should have them, and how many they may wish to have. These interventions are important, because research depicts that knowledge helps people in their decision-making process. With new fertility preservations such as egg freezing now available, additional education is needed to be sure that women and couples are well informed about the cost and low success rates of this intervention.     

Creation of an Age-Adjusted,Dual-Energy X-ray Absorptiometry–Derived Trabecular Bone Score Curve for the Lumbar Spine in Non-Hispanic US White Women

The trabecular bone score (TBS, Med-Imaps, Pessac, France) is an index of bone microarchitecture texture extracted from anteroposterior dual-energy X-ray absorptiometry images of the spine. Previous studies have documented the ability of TBS of the spine to differentiate between women with and without fractures among age- and areal bone mineral density (aBMD)-matched controls, as well as to predict future fractures. In this cross-sectional analysis of data collected from 3 geographically dispersed facilities in the United States, we investigated age-related changes in the microarchitecture of lumbar vertebrae as assessed by TBS in a cohort of non-Hispanic US white American women. All subjects were 30 yr of age and older and had an L1–L4aBMDZ-score within ±2 SD of the population mean. Individuals were excluded if they had fractures, were on any osteoporosis treatment, or had any illness that would be expected to impact bone metabolism. All data were extracted from Prodigy dual-energy X-ray absorptiometry devices (GE-Lunar, Madison, WI). Cross-calibrations between the 3 participating centers were performed for TBS and aBMD. aBMD and TBS were evaluated for spine L1–L4 but also for all other possible vertebral combinations. To validate the cohort, a comparison between the aBMD normative data of our cohort and US non-Hispanic white Lunar data provided by the manufacturer was performed. A database of 619 non-Hispanic US white women, ages 30–90 yr, was created. aBMD normative data obtained from this cohort were not statistically different from the non-Hispanic US white Lunar normative data provided by the manufacturer (p = 0.30). This outcome thereby indirectly validates our cohort. TBS values at L1–L4 were weakly inversely correlated with body mass index (r = −0.17) and weight (r = −0.16) and not correlated with height. TBS values for all lumbar vertebral combinations decreased significantly with age. There was a linear decrease of 16.0% (−2.47 T-score) in TBS at L1–L4 between 45 and 90 yr of age (vs. −2.34 for aBMD). Microarchitectural loss rate increased after age 65 by 50% (−0.004 to −0.006). Similar results were obtained for other combinations of lumbar vertebra. TBS, an index of bone microarchitectural texture, decreases with advancing age in non-Hispanic US white women. Little change in TBS is observed between ages 30 and 45. Thereafter, a progressive decrease is observed with advancing age. The changes we observed in these American women are similar to that previously reported for a French population of white women (r² > 0.99). This reference database will facilitate the use of TBS to assess bone microarchitectural deterioration in clinical practice.     

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??White spot lesions ??WSLs?? are defined as “subsurface enamel porosity from carious demineralization” which present as “a milky white opacity located on smooth surfaces”. Since bracket were bonded and introduced?? WSLs have become a particular clinical problem that can be attributed to etching of the tooth and prolonged plaque accumulation on surfaces. Plaque control is the most effective preventive measure?? while the use of infiltrantresin is currently the most popular treatment for WSLs due to the fixed orthodontic treatment with multi-brackets. This review was about white spots lesions on teeth in orthodontically treated patients.