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①目的 探讨视神经动脉起源、数目、分布及相关动脉的病理变化,为视神经因缺血所致视野缺损提供形态学依据。②方法 在体视显微镜扣手术显微镜下对100侧成人脑标本观察视神经动脉来源、数目和分布,对其中年龄50-70岁60侧脑标本的视神经和相关动脉进行病理切片观察。③结果 视神经动脉主要来源于颈内动脉、大脑前动脉争前交通动脉。其中单来源3侧(3%),双来源68侧(68%),3来源29侧(29%)。病理切片观察动脉管壁有粥样硬化改变53侧(88.3%),其中被硬化斑块阻塞眼动脉的3侧(5、7%)。阻塞垂体上动脉的4侧(7.5%),小动脉管腔狭窄11侧(20.8%)。与小动脉阻塞相对应的视神经切片。可见有神经纤维萎缩、变性等病理改变。硬化的颈内动脉壁压迫视神经可以形成明显的压迹。④结论 50岁以上出现不明原因的周边或中央视野缺损。脑动脉硬化导致视神经供血障碍病因不能除外。 相似文献
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Cyst-like lesions in the radius and tibia were observed in two children as a post-fracture event. The pathogenesis of these lesions is discussed. Cut sections from anatomic specimens display extensive hemorrhage in subperiosteal as well as endosteal and trabecular bone. Cysts arising from hemorrhagic resorption in various locales may explain the occasional atypical appearance of these lesions. 相似文献
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外固定支架与小腿皮瓣在开放性胫腓骨骨折中的临床应用 总被引:1,自引:0,他引:1
目的:报道外固定支架结合小腿内侧筋膜皮瓣在修复开放性胫腓骨骨折骨外露中的手术方法及临床应用。方法:自1998年8月~2003年5月应用外同定支架结合逆行或顺行小腿内侧筋膜皮瓣一期修复开放性胫腓骨骨折并骨外露30例。结果:30例随访4个月到5年,术后筋膜皮瓣全部成活,切口Ⅰ期愈合28例,Ⅱ期愈合2例;27例胫腓骨骨折获得临床愈合,骨折愈合时间平均为5个月,骨折愈合时间最长为术后8个月;3例骨不愈合,1年后行切开植骨术而痊愈,不愈合率10%;2例有不同程度感染,其中1例并发慢性骨髓炎.术后感染率6.7%:结论:小腿内侧筋膜皮瓣血供良好,手术操作简单、不损伤小腿主要血管等优点,结合外固定支架技术是修复开放性胫腓骨骨折骨外露的一种可供选用的方法,特别适合于基层医院开展。 相似文献
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目的:评价双盘封堵器介入治疗继发孔型房间隔缺损(ASD)的临床疗效及安全性。方法:在X线透视和经食道超声心动图(TEE;13岁以下儿童经胸超声心动图,TTE)监视下,采用经皮穿刺放置封堵器方法治疗继发孔型ASD16例,术后立刻、24h、1月、3月进行TEE或TTE和X线胸片检查,以评价其疗效。结果:本组16例封堵器置入均获成功。其中9例术后胸闷症状立即消失,第2天即能下床活动,无特殊不适主诉;另7例症状任2周后逐渐好转。1例术后仍有微量分流,3个月后分流才消失;术后1个月有8例右房及右室内径较术前缩小。14例术后3个月TTE显示ASD无残余分流,封堵器位置良好;另2例失访。结论:经皮封堵治疗继发孔型ASD,是一种有效的介入治疗方法,具有安全、有效、操作简便,成功率高的特点。 相似文献
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Gabrielle T. Lemire Éliane Beauregard‐Lacroix Philippe M. Campeau Stefan Parent Marjolaine Roy‐Beaudry Dorothée Dal Soglio Andrée Grignon Françoise Rypens Sandrine Wavrant Marie‐Ange Delrue 《American journal of medical genetics. Part A》2020,182(4):664-672
Our objectives were to describe fetal cases of vertebral defects (VD), assess the diagnostic yield of fetal chromosomal analysis for VD and determine which investigations should be performed when evaluating fetal VD. We performed a retrospective chart review for fetuses with VD seen between 2006 and 2015. Cases were identified from CHU Sainte‐Justine's prenatal clinic visits, postmortem fetal skeletal surveys, and medical records. Cases with neural tube defects were excluded. Sixty‐six fetuses with VD were identified at a mean gestational age of 20 weeks. Forty‐seven (71.2%) had associated antenatal anomalies, most commonly genitourinary, skeletal/limb, and cardiac anomalies. Thirteen mothers (19.7%) had pregestational diabetes (95% CI [10.1%–29.3%]). Fifty‐three cases had chromosomal analysis. Three had abnormal results (5.6%): trisomy 13, trisomy 22, and 9q33.1q34.11 deletion. Thirty‐four (51.5%) pregnancies were terminated, one led to intrauterine fetal demise and 31 (46.9%) continued to term. Of 27 children who survived the neonatal period, 21 had congenital scoliosis and 3 had spondylocostal dysostosis. Seven had developmental delay. In conclusion, prenatal evaluation of fetuses with VD should include detailed morphological assessment (including fetal echocardiogram), maternal diabetes screening, and chromosomal microarray if non‐isolated. Our findings provide guidance about management and counseling after a diagnosis of fetal VD. 相似文献
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Miller JS Curtsinger J Berthold M Malvey K Bliss RL Le CT Fautsch SK Dudek AZ Blazar BR Panoskaltsis-Mortari A 《Clinical immunology (Orlando, Fla.)》2005,117(2):144-151
Relapse is the most common cause of treatment failure for advanced cancer, even those treated with autologous hematopoietic cell transplantation (HCT). Effective tumor-specific immunotherapy may decrease relapse, however, this will fail if the immune system is unable to respond. We developed a strategy to test immune responses with a single injection of the bona fide neo-antigen KLH. The model was first tested in 37 normal volunteers using three KLH vaccines: Intracel KLH, Biosyn KLH, and Biosyn KLH + adjuvant. Despite finding the immunogenic epitope conserved in both products, intact Intracel KLH induced a better response compared to a purified 350/390 kDA subunit of KLH contained in the Biosyn KLH product. Addition of a synthetic oil adjuvant (Montanide ISA51) restored the response to a single injection of Biosyn KLH. A quantitative readout measured by a KLH-specific cellular and humoral response with isotype switching 1 month after KLH vaccination was established. To test the integrity of the adaptive immune response in cancer patients, we vaccinated 14 patients post-HCT and 19 patients with advanced cancer with KLH vaccines that elicited a 100% response rate in normal volunteers. In marked contrast to normal subjects, both responses were significantly impaired up to 16 months after autologous HCT with an intermediate response in advanced cancer patients. KLH vaccines are safe and require only a single injection to test neo-antigen responses providing an optimal platform for definitive testing of strategies to improve diminished immune recovery after chemotherapy or post-HCT. 相似文献