输尿管皮肤造口患者单J管更换就诊延迟的质性研究

目的深入了解输尿管皮肤造口患者对单J管更换就诊延迟的认知及影响因素,为采取更有效的干预提供依据。方法运用质性研究中的现象学研究方法,分析14例输尿管皮肤造口患者单J管更换就诊延迟的真实感受。结果患者单J管更换就诊延迟主要表现为焦虑、侥幸和麻木3种心理;经济保障不足、路途遥远、家庭支持不足和相关知识缺乏是影响其就诊延迟的原因。结论输尿管皮肤造口患者术后门诊单J管定期更换依从性差,既有主观上的认知缺陷,也有客观上的就医障碍。期待多部门共同合作,增强患者门诊定期换管的依从性,改善其生活质量。     

3D printing in designing of anatomical posterior column plate

Background

Acetabulum has a complex anatomy due to which anatomical acetabular plates are still under developmental phase. Although intra-operative contouring of reconstruction plate is done as a standard practice, it is associated with increased operative time and morbidity of patient. We have designed an acetabular plate for posterior fixation from experience of previous studies performed in our institute on acetabular fracture fixation which should be appropriate for most of the patient of Indian origin. Apart from avoiding intra-operative contouring of acetabular plates it also helps in preventing intra articular screw penetration.

可注射原位给药体系在蛋白类药物给药中的应用

可注射进入病灶部位并能原位给药的体系具有操作简单、局部给药、延长药物释放时间、减少用药剂量等诸多优点.近年来,各国研究者竞相研究可注射原位给药体系,并将其作为亲水性大分子药物尤其是蛋白类药物的药物载体.本文主要介绍了热塑性糊状体、原位交联聚合物体系、原位聚合物沉淀和热诱导凝胶体系四种缓释药物体系,着重讨论了将其作为蛋白类药物载体的优缺点.