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21.
Prof. K. Loeschke MD B. Ueberschaer MD A. Pietsch E. Gruber MD K. Ewe MD B. Wiebecke MD W. Heldwein MD R. Lorenz MD 《Digestive diseases and sciences》1996,41(10):2087-2094
Relapse prevention by dietary n-3 fatty acids (5.1 g/day) was studied in a double-blind, placebo-controlled trial of 64 patients with ulcerative colitis in remission and off steroids. 5-ASA compounds were stopped three months after randomization and clinical disease activity monitored for two years. Macroscopic and histologic activity and extension was assessed by colonoscopy at entry and at exit. Both treatment groups were well matched at start. Nine patients on placebo and eight on n-3 fatty acids stopped taking their medication prematurely. Actuarial relapse-free survival was improved by n-3 fatty acids only during months 2 and 3 (2P<0.05–0.01), but cumulative relapse rate at two years was similar for those taking placebo (18/33=55%) and n-3 fatty acids (18/31=58%). There was also no consistent difference in clinical, macroscopic, and histologic disease activity between treatment groups. The n-3 fatty acids temporarily retard, but do not prevent, relapse of ulcerative colitis. 相似文献
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本实验用纯系CFW小鼠与Wistar大鼠建立“虚证”模型。以环核苷酸系统反应性为指标观察了肉桂挥发油的作用。通过气相色谱及气质联用等方法研究表明,本实验所提取的挥发油中桂皮醛含量约为92%。肉桂挥发油可显著降低“阳虚”——甲状腺素缺乏(甲减)模型升高了的cGMP系统反应性而使其降低了的耗O_2率升高;这是一种治疗作用。肉桂挥发油可显著升高“阴虚”——甲状腺素过多(甲亢)模型已升高了的cAMP系统反应性并使其升高了的耗O_2率进一步升高,这是一种恶化作用。这两种作用与中医对症治疗的原则是一致的。 相似文献
25.
Objective and Design: Whilst the anti-microbial properties of tea tree oil (TTO) are established, the anti-inflammatory effects of TTO in human skin remain largely anecdotal and require evaluation. This study examined the effect of topically applied TTO on nickel-induced contact hypersensitivity reactions in human dorsal skin.Treatment: TTO (100%), a 5% TTO lotion, a placebo lotion (no TTO), or 100% macadamia oil were applied at days 3 and 5 after nickel exposure.Methods: The flare area and erythema index were measured on days 3, 5 and 7. The regulatory effects of TTO were also investigated on the proliferative response to nickel or polyclonal mitogens by peripheral blood mononuclear cells from nickel-sensitive and control subjects.Results: TTO (100%) significantly reduced the flare area and erythema index when compared to the nickel-only sites. With respect to the erythema index, the anti-inflammatory effects were predominantly, but not exclusively, seen in a subgroup of nickel-sensitive subjects with a prolonged development phase of nickel-induced contact hypersensitivity response. The 5% TTO lotion, the placebo lotion and the 100% macadamia oil were all without significant effect. TTO significantly inhibited proliferation to nickel but not to non-specific polyclonal mitogens by peripheral blood mononuclear cells from nickel-sensitive subjects.Conclusions: Topical application of 100% TTO may have therapeutic benefit in nickel-induced contact hypersensitivity in human skin. The mode of action of TTO requires further investigation, but may be an effect on the antigen presenting cells or the antigen presenting process in nickel-induced contact hypersensitivity, as well as vascular changes associated with this response.Received 14 February 2004; returned for revision 30 June 2004; accepted by J. S. Skotnicki 13 September 2004 相似文献
26.
Mohammad Lutfur Rahman Masato Aoyama Shoei Sugita 《Anatomical science international / Japanese Association of Anatomists》2008,83(4):239-246
This study was intended to determine the number and density of both retinal ganglion cells and the oil droplets of cone photoreceptor
cells in brown-eared bulbul (Hysipetes amaurotis). For this study birds were killed with proper dose of anesthetic (pentobarbital, 30 mg/kg), and the eyes were removed from
the orbital cavity to isolate the retina. For the ganglion cell study retinal whole-mount specimens were prepared and stained
with 0.1% cresyl violet. The different types of oil droplets were counted from color microphotographs of freshly prepared
retinal samples. The mean total number of ganglion cells was estimated at approximately 2.5×106; with an average density of 16 523 cells/mm2. Two high-density areas, namely the central area (CA) and the dorso-temporal area (DTA), are located in the central and dorso-temporal
retinas, respectively, in bulbuls (24 032 cells/mm2 in the CA; 23 113 cells/mm2 in the DTA). Small ganglion cells persisted in the highest density areas, whereas the largest soma sizes were found in the
lowest density areas of the retina. Four types of different colored oil droplets — red, orange, green and clear — were identified
with an average density of 29 062/mm2. Among the different colors, the green oil droplets had a significantly higher population (13 083/mm2) than the others across the retina. The central retina had a significantly higher number of all types of oil droplets, at
a density of 60 552/mm2. The density and size of the different colored oil droplets were inversely related across the regions of the retina. Taken
together, it is concluded that the CA of the retina is an excellent quality area for visual perception due to peak density
of ganglion cells and oil droplets. Moreover, each specific oil droplet makes a distinct contribution to visual perception,
thereby ensuring that the bird has a retina that best matches its natural environment and feeding behavior. 相似文献
27.
James L. Rae Richard A. Levis 《Pflügers Archiv : European journal of physiology》1992,420(5-6):618-620
Summary We present a method whereby, with integrating electronics, quartz patch electrodes and a novel use of silicone oil, background noise levels as low as .083 pA RMS in a 5 kHz bandwidth (4-pole Butterworth filter) have been achieved in single channel patch clamp recordings. These approaches result in much higher signal to noise ratios for single channel recording than have previously been reported and should allow many investigators to significantly reduce noise at a constant bandwidth or to increase their recording bandwidths by several kHz. 相似文献
28.
胡萝卜籽挥发油的抗生育作用 总被引:3,自引:0,他引:3
胡萝卜籽挥发油对小鼠有抗着床,抗早、中和晚期妊娠作用。对大鼠也有抗着床作用。挥发油中的萜类碳氢化合物部位,对小鼠皮下注射抗早期妊娠的ED_(50)为2.9ml/kg,甲地孕酮和hCG能明显逆转其作用;对假孕小鼠蜕膜瘤有抑制作用,此作用不能被甲地孕酮拮抗,皮下注射于早孕大鼠24、48小时后血浆孕酮浓度明显下降。以上提示其抗早孕作用机制可能与抑制孕酮合成和蜕膜反应有关。此外,挥发油碳氢部分无雌激素和抗雌激素活性,低浓度时对早孕大鼠离体子宫的收缩活动没有影响,高浓度则表现抑制作用。 相似文献
29.
Terpene hydrocarbons in Pimpinella anisum L. 总被引:1,自引:0,他引:1
The essential oil of anise (fruits and shoots) was investigated focusing on the composition of the hydrocarbon fraction. Several sesquiterpenes were identified by GC-MS and the relative composition of the fractions was established by GC analysis. -Himachalene and the diterpene neophytadiene were isolated by TLC and column chromatography at low temperatures. Their structures were determined by MS and NMR including1H-1H correlated COSY and NOE experiments. 相似文献
30.
Daniel Gonzlez-Hedstrm Teresa Priego Asuncin Lpez-Caldern Sara Amor María de la Fuente-Fernndez Antonio Manuel Inarejos-García ngel Luis García-Villaln Ana Isabel Martín Miriam Granado 《Nutrients》2021,13(1)
Aging is associated with a progressive decline in skeletal muscle mass, strength and function (sarcopenia). We have investigated whether a mixture of algae oil (25%) and extra virgin olive oil (75%) could exert beneficial effects on sarcopenia. Young (3 months) and old (24 months) male Wistar rats were treated with vehicle or with the oil mixture (OM) (2.5 mL/kg) for 21 days. Aging decreased gastrocnemius weight, total protein, and myosin heavy chain mRNA. Treatment with the OM prevented these effects. Concomitantly, OM administration decreased the inflammatory state in muscle; it prevented the increase of pro-inflammatory interleukin-6 (IL-6) and the decrease in anti-inflammatory interleukin-10 (IL-10) in aged rats. The OM was not able to prevent aging-induced alterations in either the insulin-like growth factor I/protein kinase B (IGF-I/Akt) pathway or in the increased expression of atrogenes in the gastrocnemius. However, the OM prevented decreased autophagy activity (ratio protein 1A/1B-light chain 3 (LC3b) II/I) induced by aging and increased expression of factors related with muscle senescence such as histone deacetylase 4 (HDAC-4), myogenin, and IGF-I binding protein 5 (IGFBP-5). These data suggest that the beneficial effects of the OM on muscle can be secondary to its anti-inflammatory effect and to the normalization of HDAC-4 and myogenin levels, making this treatment an alternative therapeutic tool for sarcopenia. 相似文献