米索前列醇联合硫酸镁治疗妊娠高血压综合征产后出血37例

目的 观察米索前列醇联合硫酸镁治疗妊娠高血压综合征产后出血的疗效.方法 回顾性分析2011年6月至2012年12月妊娠高血压综合征产后出血71例产妇的临床资料,其中对照组34例给予催产素联合硫酸镁治疗;治疗组37例给予米索前列醇联合硫酸镁治疗,比较两组疗效.结果 治疗组产后2h和产后2～24h内的出血量均低于对照组(P＜0.05);两组不良反应差异无统计学意义(P＞0.05).结论 米索前列醇联合硫酸镁治疗妊娠高血压综合征产后出血效果良好,值得临床推广.     

青霉素、硫酸庆大霉素对红剑鱼、孔雀鱼和食蚊鱼的急性毒性实验

目的 :观察青霉素、硫酸庆大霉素对红剑鱼、孔雀鱼和食蚊鱼的急性毒性影响 ,以探讨红剑鱼、孔雀鱼和食蚊鱼作为水生实验动物的可行性及对药物急性毒性的检测效果。方法 :用水毒理学方法测定它们对三种鱼类的 2 4hLC50 。结果 :青霉素对红剑鱼、孔雀鱼和食蚊鱼的急性毒性观察结果 ,2 4hLC50 值分别为 2 83.0 6mg/L、2 79.92mg/L、2 89.4 4mg/L ;硫酸庆大霉素对红剑鱼、孔雀鱼和食蚊鱼的急性毒性观察结果 ,2 4hLC50 值分别为 2 95 .97ug/L、2 73.74ug/L、30 9.0 3ug/L。结论 :红剑鱼、孔雀鱼和食蚊鱼可作为急性毒性的试验材料。     

Sulfate Freeze–Thaw Resistance of Magnesium Potassium Phosphate Cement Mortar

Concrete facilities in the severe-cold areas of western China (salt lake environments and heavy saline soils) are seriously damaged by the multiple corrosion effects of freeze–thaw cycles and sulfate corrosion. Magnesium phosphate cement (MPC) cement-based material has become an ideal concrete structural component because of its superior performance. Because concrete structural repair materials are used in heavy-corrosion environments, their durability in those environments should also be considered. Regarding the salt-freezing resistance of MPC, the existing studies have all used a NaCl solution as the heat transfer medium. In addition to chlorine salt, sulfate, especially Na₂SO₄, is also common in typical use environments such as oceans, salt lakes, and groundwater. To evaluate the sulfate freeze–thaw resistance of potassium magnesium phosphate cement (MKPC) mortar, in this study the strength development, weight loss, and water absorption of MKPC mortar specimens subjected to different freeze–thaw cycles were tested and compared with those for Portland cement (P.O) mortar specimens of the same strength grade. The results showed that the P.O mortar specimen completely lost its strength after 75 cycles of rapid water freezing and thawing and 50 cycles of sodium sulfate solution (5%) freezing and thawing. However, the residual strength rating of the MKPC mortar specimen after 75 cycles of water freezing and thawing and 100 cycles of sodium sulfate solution freezing and thawing was higher than 75%. After 50 rapid freeze–thaw cycles in water and a 5% Na₂SO₄ solution, the P.O mortar specimen’s mass loss exceeded the 5% failure standard, whereas the mass loss of the MKPC mortar specimens was much less than 5%. Before the freeze–thaw cycles, the water absorption of the P.O mortar specimen was close to 8 times that of the MKPC mortar specimen, and after 50 water freeze–thaw cycles and 25 sulfate solution freeze–thaw cycles, the water absorption reached 4.88% and 5.68%, respectively. However, after 225 freeze–thaw cycles in water and the sulfate solution, the water absorption rates of MKPC mortar specimens were 2.91% and 2.51% respectively. The test and analysis results show that the freeze–thaw resistance of MKPC mortar was much higher than that of Portland cement mortar specimens. Those results provide a prerequisite for applying and expanding the use of MKPC-based materials in severe-cold areas of western China (salt lake and heavily saline soil environments).     

噻唑烷二酮类药物对糖尿病肾病的直接作用及其机制

近年的研究显示 ,噻唑烷二酮类药物 (TZD)具有不依赖于胰岛素增敏作用的肾直接保护作用 ,在未降低糖尿病大鼠高血糖水平的情况下 ,TZD可减少清蛋白尿 ,抑制肾小球系膜肥大及细胞外基质 (ECM)增生。其可能的作用机制是 :在高血糖状态下 ,TZD通过激活肾小球中二酰基甘油激酶 (DGK) ,抑制二酰基甘油 (DAG) 蛋白激酶C(PKC) 细胞信号调节激酶 (ERK)通路活性而改善肾小球高滤过状态、抑制ECM蛋白的过度产生。也有研究认为 ,TZD与改善硫酸乙酰肝素原多糖 (HSPG)合成及硫酸化、从而抑制肾小球基膜 (GBM)外疏松层的阴离子位点有关。此外 ,TZD可能通过调节肾小球系膜细胞的表型转化达到肾保护作用。     

HPLC法测定硫酸头孢匹罗的含量及有关物质

目的:建立硫酸头孢匹罗含量及其有关物质的HPLC检测方法.方法:采用Lichrospher-C18色谱柱(250 mm×4.6 mm,5 μm);流动相为 0.03 mol·L-1磷酸二氢铵缓冲液(pH3.3)-乙腈(9:1),流量 1.0 mL·min-1,检测波长 270 nm.结果:硫酸头孢匹罗在149.1～347. 9 μg·mL-1浓度范围内线性关系良好(r=0.9999),与中间体1、中间体2及副产物完全分离,中间体1和中间体2的最低检测浓度分别为 27.2 ng·mL-1、25.8 ng·mL-1.结论:本测定法简便快速,灵敏度高,准确可靠,可同时测定硫酸头孢匹罗的含量及有关物质.     

硫酸镁和川芎嗪对新生鼠缺氧缺血性脑损害的预防作用

建立新生鼠缺氧缺血性脑病（HIE）的模型，观察了大脑皮质超氧化物歧化酶（SOD）、丙二醛（MDA）、血清MDA和脑组织神经病理变化以及硫酸镁、川芎嗪对其影响。发现HIE组大脑皮质SOD、MDA和血清MDA升高明显，神经细胞变性显著。硫酸镁和川芎嗪能使大脑皮质SOD、MDA和血清MDA降低，神经细胞变性减轻。提示氧自由基在缺氧缺血性脑损害发病中的影响和硫酸镁、川芎嗪通过间接抗氧化作用对HIE的预防作用。     

硫酸镁治疗室上性快速心律失常

作者用硫酸镁治疗室上性快速心律失常25例,结果:阵发性室上性心动过速10例中6例作终止治疗,4例显效,4例作预防性治疗,3例好转;紊乱性房性心动过速3例于治疗后1小时至2日内纠正;快速房颤4例在治疗后半小时内心室率得到缓解;非阵发性交界区心动过速8例在治疗后10小时至2日内纠正。表明硫酸镁为治疗室上性快速心律失常的一种有效制剂。     

硫酸镁治疗扭转型室性心动过速

本文报告扭转型室性心动过速6例,结合文献共分析11例,着重对硫酸镁治疗此病进行了讨论。认为对急性心肌梗塞、心绞痛、高血压病患者,以及对异丙肾上腺素不能耐受者,而镁剂不失为安全、速效而又简单的抢救治疗措施之一。并对镁的治疗机理、剂量、给药途径和毒性进行了探讨。     

硫酸无叶豆碱对离体神经肌肉接头的作用

硫酸无叶豆碱(SP)对离体大鼠膈神经-膈肌标本的作用,可使电刺激膈神经所致膈肌收缩产生浓度依赖性抑制。在较低浓度时使部分膈肌标本出现收缩短暂增强的现象。较高浓度时对直接刺激膈肌所致收缩,也有一定抑制作用。SP于4×10~(-4)M时,不引起膈肌细胞膜电位的明显变化;但浓度增至2×10~(-3)M时,则有明显去极化作用。SP先使小终板电位(mepp)出现短暂的兴奋,频率增加和幅度增大,然后转为抑制。SP也能降低终板电位(epp)幅度;使epp量子含量发生先兴奋后抑制的双相变化。以上结果提示SP对神经肌肉传递的作用,有突触前和突触后两种因素参与。     

硫酸镁联合银杏达莫治疗慢性肺源性心脏病的疗效观察

目的探讨硫酸镁联合银杏达莫治疗慢性肺源性心脏病的疗效。方法将笔者所在医院2011年3月～2012年3月72例慢性肺源性心脏病患者随机分成对照组和治疗组,对照组患者进行常规的抗感染、保持呼吸道通畅、利尿、扩张血管、纠正电解质平衡等治疗;治疗组在对照组的基础上加用硫酸镁和银杏达莫。观察两组患者治疗前后心功能、肺动脉收缩压的改善情况,并进行临床观察分析。结果治疗组的总有效率明显高于对照组,差异有统计学意义(P<0.05)。结论硫酸镁联合银杏达莫治疗慢性肺源性心脏病疗效显著,临床上建议进一步推广运用。