胃溃疡90例临床观察

目的:探讨90例胃溃疡患者的临床疗效。方法:采用回顾性分析的方法,分析90例胃溃疡患者的临床资料,依据治疗方式不同分为观察组和对照组。结果:观察组临床症状改善明显优于对照组,观察组临床疗效明显高于对照组,两组比较差异有统计学意义(P<0.05)。结论:泮托拉唑+阿莫西林+枸橼酸铋钾治疗胃溃疡临床疗效明显,值得临床推广应用。     

硝酸铋与丙磺舒合用对顺铂肾毒性的防护作用

毒性剂量的顺铂（ＣＰ３０μｍｏｌ·ｋｇ－１ｉｐ）可引起血尿素氮（ＢＵＮ）升高。硝酸铋（ＢＮ）５μｍｏｌ·ｋｇ－１于ＣＰ前４８和２４ｈｓｅ，丙磺舒（Ｐｒｏ）７００μｍｏｌ·ｋｇ－１于ＣＰ前１５，１ｈ及ＣＰ后５ｈｉｇ，或ＢＮ与Ｐｒｏ二者半量合用，按上述给药，均能抑制ＣＰ引起的ＢＵＮ升高，尤以ＢＮ＋Ｐｒｏ组抑制作用显著。肾脏光镜和电镜标本显示，ＣＰ使肾小管受损严重；ＢＮ组，Ｐｒｏ组和ＢＮ＋Ｐｒｏ组均使ＣＰ引起的肾小管受损减轻，尤以ＢＮ＋Ｐｒｏ组减轻明显。ＢＮ２．５－２０μｍｏｌ·ｋｇ－１剂量依赖性地诱导小鼠肾脏金属硫蛋白合成。Ｐｒｏ可使ＣＰ后２４ｂ肾铂含量明显降低；Ｐｒｏ或Ｐｒｏ＋ＢＮ使尿铂累积排出量增加，血浆铂浓度降低。提示ＰＦＯ防护ＣＰ肾毒性与其减少肾铂分布，增加尿铂排出有关。     

Evaluation of the strength and radiopacity of Portland cement with varying additions of bismuth oxide

Aim To study the effect of addition of various proportions of bismuth oxide on compressive strength and radiopacity of Portland cement. Methodology The compressive strength of white Portland cement and cement replaced with 10, 15, 20, 25 and 30% bismuth oxide was evaluated by testing cylinders 6 mm in diameter and 12 mm high. Twelve cylinders were tested for each material under study. The radiopacity of the cements tested was evaluated using an aluminium step‐wedge and densitometer. The optical density was compared with the relevant thickness of aluminium (Al). Statistical analysis was performed using Analysis of Variance (anova ) with P = 0.05 and Tukey test to perform multiple comparison tests. Results Various additions of bismuth oxide had no significant effect on the strength of the material when compared with the unmodified Portland cement (P > 0.05). The radiopacity of the cements tested ranged from 2.02 mm Al for Portland cement to 9.79 mm Al for the highest bismuth replacement. Conclusions Addition of bismuth oxide did not affect the compressive strength of Portland cement. All the bismuth oxide cement mixtures had radio‐opacities higher than 3 mm thickness of aluminium.     

Decreased bioavailability of propranolol due to interactions with adsorbent antacids and antidiarrhoeal mixtures

The interaction of propranolol (50–160 mg/100 ml) with recommended doses of magnesium trisilicate, kaolin-pectin and bismuth subsalicylate suspensions was studied. Magnesium trisilicate and bismuth subsalicylate were found to adsorb propranolol with a limiting adsorptive capacity of 112 and 97 mg/g, respectively. Kaolin-pectin suspension adsorbed practically all of the drug. The effect of these interactions on the bioavailability of propranolol in rats was determined. The extent, but not the rate. of propranolol absorption was decreased on concomitant administration of the adsorbents. Peak propranolol plasma concentrations decreased by 292 5% and a parallel decrease of 35–44% in AUC values was observed. These interactions suggest possible clinically important differences in propranolol bioavailability.     

两种短程三联方案治疗飞行员幽门螺杆菌阳性消化性溃疡疗效分析

目的研究呋喃唑酮(F)或甲硝唑(M)联用阿莫西林(A)及枸橼酸铋钾(C)1周疗法治疗飞行员幽门螺杆菌(Hp)阳性消化性溃疡的疗效。方法60例飞行员经胃镜证实惠有直径≥3mm的活动期消化性溃疡．随机分为治疗组和对照组，每组各30例。治疗组(CAF)给予呋喃唑酮0．1g，3／日；联用枸橼酸铋钾0．22g，2／日；阿莫西林1g，3／日。对照组(MAF)给予甲硝唑0．4g，3／日，联用枸橼酸铋钾0．22g，2／日；阿莫西林1g，3／日。疗程均为7日。结果溃疡愈合率，HP根除率治疗组分别为93％、93％，而对照组分别为76％、70%，两组比较差异有显著性。治疗1日、3日、7日缓解腹痛显效率治疗组分别为63％、90%、97％，对照组分别为53％、69％、76%，两组比较差异有显著性。两组均无严重不良反应，患者依从性较好。结论CAF疗法较MAF疗法疗效好，不良反应少，依从性好。是更理想的消化性溃疡治疗方案。     

HPLC法测定枸橼酸铋雷尼替丁及其片剂中雷尼替丁的含量

目的:建立HPLC测定枸橼酸铋雷尼替丁及其片剂中雷尼替丁含量的方法。方法:色谱柱为InertsilODS-3(4.6 mm×150 mm,5μm);磷酸盐缓冲液(取磷酸6.8 mL置1900 mL水中,加入50%氢氧化钠溶液8.6 mL,加水至2000 mL,用磷酸或50%氢氧化钠溶液调节pH至7.10±0.05)–乙腈(98∶2)及磷酸盐缓冲液–乙腈(78∶22)分别为流动相A、B,梯度洗脱;流速为1.2 mL.min-1,检测波长为230 nm,柱温为35℃;外标法。结果:本方法在2.5～200.4μg.mL-1范围内线性良好(r=0.9998),定量限为5 ng(以雷尼替丁计)。结论:本方法简便、灵敏、专属性好、结果准确,适用于枸橼酸铋雷尼替丁及其片剂中雷尼替丁含量的测定。     

Influence of Bi2O3 on Mechanical Properties and Radiation-Shielding Performance of Lithium Zinc Bismuth Silicate Glass System Using Phys-X Software

We analyzed the mechanical properties and radiation-shielding performance of a lithium zinc bismuth silicate glass system. The composition of these glasses is 20ZnO-30Li₂O-(50-x)SiO₂-xBi₂O₃ (x varies between 10 and 40 mol%). The mechanical properties of the investigated glass system, such as Young’s modulus (E), bulk modulus (K), shear modulus (S), and longitudinal modulus (L), were determined using the Makishima–Mackenzie model. The elastic moduli gradually decreased with the addition of Bi₂O₃. E decreased from 46 to 31 GPa, K decreased from 27 to 14 GPa, S decreased from 19 to 14 GPa, and L decreased from 52 to 32 GPa as Bi₂O₃ was substituted for SiO₂. The mass attenuation coefficient (MAC) was investigated at energies between 0.284 and 1.33 MeV to understand the radiation-shielding performance of the glasses. The MAC value increased when SiO₂ was replaced by Bi₂O₃. We found that the effect of Bi₂O₃ on MAC values was noticeably stronger at energies of 0.284 and 0.347 MeV, while the effect of Bi₂O₃ on MAC values became weaker as energy increased. The linear attenuation coefficient (LAC) results demonstrated that if the samples were exposed to low-energy photons, the glass could prevent the penetration of photons, and thus, the glass samples were effective in radiation protection. The LAC values for the lowest- and highest-density samples changed from 0.998 to 1.976 cm⁻¹ (at 0.284 MeV) and from 0.286 to 0.424 cm⁻¹ (at 0.826 MeV). According to the radiation-shielding results, the thick, high-density glass sample has special and distinctive shielding properties.     

复方铝酸铋片结合奥美拉唑治疗慢性浅表性胃炎的效果及对复发率的影响

目的 分析复方铝酸铋片结合奥美拉唑治疗慢性浅表性胃炎的效果及对复发率的影响.方法 选取我院2019年10月至2021年2月收治的120例慢性浅表性胃炎患者作为研究对象,采用电脑盲选法将其分为对照组(60例,奥美拉唑)和研究组(60例,复方铝酸铋片+奥美拉唑).比较两组患者的胃肠激素、炎症介质水平、免疫功能指标、不良反应...