奥替溴铵、比特诺尔和地芬诺酯治疗肠易激综合征的双盲随机对照研究

目的 探讨奥替溴铵、比特诺尔和地芬诺酯对IBS的治疗作用及副作用。方法 201例IBS腹泻型和腹痛型患者按照双讯随机对照观察分为A组（奥替溴铵）、B组（比特诺尔）和C组（地芬诺酯）。所有患者均需进行治疗前、后症状评分。疗效判断标准为：显著、中度、轻度缓解和无效。结果 三组治疗后症状平均积分均显著低于治疗前（P≤0.048)。A组和C组中度以上缓解率（69.4%和72.1%)显著高于B组（50.75,p=0.029,0.01)。A组治疗后腹痛、腹胀、排便异常感和腹部触痛积分均性减低（P＝0.000-0.039)，B组和C组治疗后腹痛、排便异常（排便次数增多、大便性状、黏液便）和腹部触痛积分和组内平均积分显著低于治疗前（P≤0.047)。A组副作用发生率（8.1%)显著低于B组（23.9%,P=0.014)和C组（35.3%,P=0.000)，主要由于B组（12.7%)和C组（25.0%)便秘发生增加。结论 上述三种药物对IBS的治疗均有效，其中奥替溴铵选择性作用于腹痛型，比特诺尔和地芬诺酯主要作用于腹泻型。奥替溴铵副作用少，耐比特诺尔和地芬诺酯长期使用易导致便秘。     

益生菌辅助含铋剂四联疗法根除幽门螺杆菌的临床研究

目的 探讨益生菌联合铋剂四联疗法能否在一定程度上提高幽门螺杆菌根除率,同时缩短根治幽门螺杆菌用药时间,降低抗菌药使用过程中的相关不良反应.方法 选取2018年1月1日—2019年4月30日在温州医科大学附属第二医院消化内科就诊,并经证实存在幽门螺杆菌感染者600例,随机分为4组,每组150例.A组:予阿莫西林胶囊1.0...     

复方铋合剂的制备及质量控制

目的 制备复方铋合剂(MBC)并建立其质量控制方法 .方法 以枸橼酸铋铵为主药与氯化钾、甘油、陈皮酊等配成复方铋合剂,采用络合滴定法检测本品中铋的含量,并对制剂的稳定性进行了观察.结果 复方铋合剂的制备工艺简单,质量稳定,含量测定快速、准确.结论 该制剂工艺可用于常规制备复方铋合剂.     

Inhibition of Bacterial Adherence on the Surface of Stents and Bacterial Growth in Bile by Bismuth Dimercaprol

Bacterial infection and biofilm formation on the surface of biliary stents is believed to be one of the main factors in stent occlusion. This study explored the role of the new reagent, bismuth dimercaprol, in preventing bacterial adherence and bacterial biofilm formation on the surface of biliary stents. Sterile porcine bile preparations, infected separately with Escherichia coli, Klebsiella pneumoniae, Enterobacter, and Enterococcus, were used as the perfusion media in an in vitro perfusion system. The bacterial growth in the media and the bacterial adherence on the surface of stents were tested when different concentrations of bismuth dimercaprol were used in the perfusion media. BisBAL (5 μ M) did not inhibit the growth of any of the tested bacterial species. It did, however, significantly decrease the amount of bacteria adhering to the surface of stents for all bacterial strains except Escherichia coli. Bismuth dimercaprol (20 μ M) significantly inhibited the growth of Escherichia coli, Klebsiella pneumoniae, and Enterobacter and, thereby, significantly decreased the amount of these bacteria adhering to the surface of stents. The unique bactericidal and anitbiofilm activities of bismuth thiols might contribute to delaying the process of biliary stent occlusion if the effective concentrations of bismuth thiols could be delivered to the target sites. The feasibility of this application of bismuth thiols deserves further investigation.     

益气健脾化瘀法治疗慢性胃炎临床研究

目的：探讨益气健脾化瘀法治疗慢性胃炎的疗效。方法：将90例患者随机分为两组。治疗组60例采用益气健脾化瘀法治疗,药用丹参、檀香、砂仁、党参、白术、茯苓、枳壳、厚朴、黄连、吴茱萸、百合、乌药、甘草治疗。对照组30例采用法莫替丁片合果胶铋胶囊治疗。结果：治疗组痊愈28例,显效12例,有效17例,无效3例,有效率95.00%;对照组痊愈8例,显效11例,有效6例,无效5例,有效率83.00%;两组有效率比较差异有显著性意义（P〈0.05）,治疗组疗效优于对照组。结论：益气健脾化瘀法治疗慢性胃炎疗效满意。     

Efficacy of two triple eradication regimens in children with Helicobacter pylori infection

Triple therapy with bismuth subsalicylate, amoxicillin, metronidazole (BAM) or with omeprazole, amoxicillin, clarithromycin (OAC) has been commonly used for the eradication of Helicobacter pylori infection. We compared the efficacy of these triple therapies in children with H. pylori infection. We retrospectively analyzed results in 233 children with H. pylori infection and treated with OAC (n=141) or BAM (n=92). Overall eradication rates of triple therapy with OAC and BAM were 74% and 85%, respectively, which showed no statistical difference. Our study showed that the triple therapy with BAM was more effective for the first-line eradication of H. pylori infection in Korean children, but has no statistical difference with OAC regimen.     

四联疗法作为二线方案根除幽门螺杆菌感染的疗效

目的 :观察 2种四联疗法作为二线方案根除幽门螺杆菌 (Hp)感染的疗效。方法 :10 8例经以质子泵抑制药为基础的三联疗法根除Hp失败或根除后复发的病人 ,分为A组 5 4例和B组 5 4例。 2组均予奥美拉唑 2 0mg、胶体次枸椽酸铋 2 4 0mg及甲硝唑 4 0 0mg ,po ,bid ,A组加四环素 5 0 0mg ,po ,qid ;B组加阿莫西林 10 0 0mg ,po ,bid ;疗程均为 7d。疗程结束 1mo后复查Hp。结果 :A ,B 2组Hp根除率按方案分析分别为 82 % (42 / 5 1)和 81%(42 / 5 2 ) ,按意图治疗分析均为 78% (42 / 5 4)。 2组不良反应发生率分别为 2 3% (15 / 5 3)和 11% (6 /5 3)。 2组间疗效比较差异无显著意义 (P >0 .0 5 )。结论 :2种四联疗法作为二线方案根除幽门螺杆菌均有良好的疗效 ,且疗效相近 ,无严重不良反应     

Determination of the PIC700 Ceramic’s Complex Piezo-Dielectric and Elastic Matrices from Manageable Aspect Ratio Resonators

Achieving good piezoelectric properties, such as the widely reported d₃₃ charge coefficient, is a good starting point in establishing the potential applicability of piezoceramics. However, piezoceramics are only completely characterized by consistent piezoelectric-elastic-dielectric material coefficient matrices in complex form, i.e., including all losses. These matrices, which define the various alternative forms of the constitutive equations of piezoelectricity, are required for reliable virtual prototyping in the design of new devices. To meet this need, ten precise and accurate piezoelectric dielectric and elastic coefficients of the material, including all losses, must be determined for each alternative. Due to the difficulties arising from the coupling of modes when using the resonance method, this complete set of parameters is scarcely reported. Bi_0.5Na_0.5TiO₃-based solid solutions are already commercially available in Europe and Japan. Here, we report a case study of the determination of these sets of material coefficients (d_iα, g_iα, e_iα and h_iα; s^E,D_αβ and c^E,D_αβ; ε^T_ik and ε^S_ik; and β^T_ik and β^S_ik), including all losses, of the commercial PIC700 eco-piezoceramic. Plate, disk, and cylinder ceramic resonators of a manageable aspect ratio were used to obtain all the material coefficients. The validation procedure of the matrices is also given by FEA modeling of the considered resonators.