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排序方式: 共有116条查询结果,搜索用时 15 毫秒
1.
目的通过建立去势比格犬模型,观察绝经早期腹部脂肪变化规律,并通过对脂肪与骨代谢相关血清学指标的测量与分析,探讨脂肪及骨代谢的关键影响因素。方法选取6只成年雌性比格犬进行去势术,分别在术前、术后4个月、6个月、10个月进行腰椎定量CT(quantatitive computed tomography,QCT)腹部脂肪面积、骨密度(bone mineral density,BMD)、MRI腰椎骨髓脂肪含量及血清学指标的检测,比较不同时间各指标的变化趋势及关系。结果比格犬腹内脂肪面积(visceral fat area,VFA)、皮下脂肪面积(subcutaneous fat area,SFA)、腹部总脂肪面积(total fat area,TFA)在术后6个月、10个月均增加(P0.05),术后10个月VFA增加百分比均值为84.39%,且为三者中最大;术后比格犬BMD并未明显降低。体重、BMD、瘦素(leptin,LP)、VFA、高密度脂蛋白(high-density lipoprotein,HDL)与SFA相关。SFA、体重、低密度脂蛋白(low-density lipoprotein,LDL)、内脏脂肪素(visfatin,VFN)与BMD相关。结论去势比格犬模型可用于研究绝经后雌激素缺乏所引起的脂肪代谢变化,但短期内BMD并未明显丢失,骨、脂肪代谢之间存在交互作用。 相似文献
2.
Jian-Hui Wu Zu-Yue Sun Yan Zhu En-Hong Zhong Gui-Lin He Gui-Ming LiuNational Key Laboratory of Planned Parenthood DevicesResearch Shanghai Institute of Planned Parenthood Research National Evaluation Centre for the Toxicology of FertilityRegulating Drugs Shanghai China 《Asian journal of andrology》2003,(4)
Objective: To establish a prostatic hyperplasia model with beagle dogs. Methods: Twenty-four male beagle dogs, 2 years of age, were divided into the treatment and control groups at random and were administrated testosterone propionate (TP) i.m. two months after castration. Three treatment groups were set with the doses of TP at 0.8 mg/kg, 2.5 mg/kg and 7.5 mg/kg, respectively, and the control was given the same volume of vehicle. Two months later, half of the animals were killed and sera samples were obtained. The wet weight and volume of prostate were measured. The dihydro testosterone (DHT) level of the serum and prostate were determined with the commercial radioimmunoassay (RIA) kit. The prostate was sectioned, fixed and stained with hematoxylin and eosin. Pictures were taken with a digital camera under the microscope and were analyzed with a computer for the epithelial cell height and the acinar luminal area with micro image analysis software. The prostate volume was measured with ultrasonic diagnost 相似文献
3.
Zbigniew Zylicz D. J. Theo Wagener Marina Garzotto Tom B. Vree Eppo van der Kleijn Leon A. G. M. van den Broek Harry C. J. Ottenheijm 《Investigational new drugs》1990,8(1):25-32
Summary N-pentyl-sparsomycin (PSm) is a lipophilic analogue of sparsomycin (Sm), which is a well known inhibitor of protein synthesis. This compound was selected for preclinical pharmacokinetic studies because of its high in vitro and in vivo antitumor activity. In this study in which the drug was evaluated in beagle dogs under anaesthesia, the drug concentrations in plasma, urine and bile samples were determined using high performance liquid chromatography (HPLC). Plasma protein binding was approximately 54%. The mean t1/2 was 0.2 hours (12 minutes) and t1/2 was 0.75 ± 0.1 hours (45 ± 6 minutes). During continuous infusions up to 5.25 hours, the steady state was reached in 3 out of 6 experiments, suggesting that in some cases the real t1/2 was longer than measured. PSm was actively reabsorbed from the renal tubuli. This process was saturable at the higher doses. Tubular reabsorption played only a minor role in pharmacokinetics as most of the drug (67%) was eliminated by the non-renal clearance. The non-renal clearance was saturable at higher doses of PSm and was the reason for non-linearity of pharmacokinetics. 相似文献
4.
Black-pigmented, asaccharolytic Bacteroides species resembling Porphyromonas gingivalis (Bacteroides gingivalis) from beagle dogs 总被引:1,自引:0,他引:1
T. Yamasaki A. Nagata T. Kiyoshige M. Sato R. Nakamura 《Oral microbiology and immunology》1990,5(6):332-335
Black-pigmented, asaccharolytic Bacteroides strains, which positively reacted with anti-Bacteroides gingivalis (now reclassified as Porphyromonas gingivalis) serum, were isolated from beagle dogs, and their characteristics were studied and compared with those of P. gingivalis. The strains from dogs were different from P. gingivalis in their catalase activity, nutritional requirements and oxygen tolerance, and double-immunodiffusion tests showed serological dissimilarity between the strains from dogs and P. gingivalis. However, the strains from dogs had guanine-plus-cytosine contents of 49.0 to 49.3 mol %, which were very similar to P. gingivalis, and they showed strong DNA-DNA hybridization with P. gingivalis. These results indicated that beagle dogs had Porphyromonas species analogous to P. gingivalis in their oral cavities. 相似文献
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目的:以延期和即刻两种方式建立种植体植入Beagle犬下颌骨的动物模型,用以比较研究延期与即刻两种种植方式的种植体周围组织状况差异。方法:选用纯系动物Beagle犬四只,分为两组:延期种植(A组),即刻种植(B组),分别以延期和即刻两种方式将种植体植入Beagle犬下颌骨,并对两种方式植入的种植体进行mPLI、PD、松动度、GI及骨吸收量的比较。结果:种植体植入顺利,种植体植入后均稳固,各项临床检测指标无统计学差异。结论:成功建立延期种植与即刻种植的口腔种植体Beagle犬动物模型,尚不能定论即刻与延期哪种种植方式更好,临床种植方式的选择还需结合临床具体情况,严格控制适应症。 相似文献
7.
目的应用植入式遥测技术建立清醒比格犬动物模型,为药物临床前安全药理学评价研究提供理想的动物模型。方法选择6~8月龄、整体状况良好的比格犬,戊巴比妥钠(40 mg/kg,iv)麻醉后,通过外科手术,分别在胸腔、腹腔以及皮下植入呼吸压力导管、植入体主体和生物电(ECG)测定电极,股动脉插入血压测定压力导管,并进行细致周到的术后护理以防并发症的发生。植入手术成功后通过无线电遥测装置,经DSI清醒动物遥测系统自动记录、储存和分析动物在清醒状态下ECG、血压、呼吸和温度等生理参数。结果与结论成功地建立了植入式清醒比格犬动物模型,获得了稳定的ECG、呼吸、血压、体温等图形和数据。植入手术的操作及术后护理是建立植入式清醒比格犬动物模型成败的关键因素。 相似文献
8.
目的探讨普萘洛尔对比格犬诱导急性心力衰竭模型的可行性。方法静脉推注普萘洛尔诱导急性心力衰竭,静脉滴注普萘洛尔维持心衰,股动脉插管监测血流动力学指标变化,电磁流量计测量心输出量。结果与造模前基础值相比,普萘洛尔造模后心率、动脉收缩压、动脉舒张压、平均动脉压、左室内压下降速度和左室收缩压均下降(P<0.05~0.01),左室舒张末期压上升(P<0.01),左室内压上升速度和心输出量分别下降51.7%、41.1%(P<0.01),达到心衰标准,且上述指标在2 h内保持稳定。结论普萘洛尔建立急性心力衰竭模型稳定可行。 相似文献
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丹参葡萄糖注射液对Beagle犬的长期毒性研究 总被引:1,自引:2,他引:1
目的 在动物体内验证丹参葡萄糖注射液 (丹参 )临床毒副反应及性质。方法 以丹参 0 .8、2 .0、5 .0 g/(kg·d)对Beagle犬连续静脉缓慢注射 15 0d及 180d ,观察用药期间毒性反应及停药 2 1d期间恢复情况。结果 丹参高剂量组用药 30~ 15 0d、中剂量组 4 5d、135d及 15 0d动物体重增长明显减慢 (P <0 .0 1,P <0 .0 5 ) ;用药期及恢复期各组动物进食量、心电图、血液学、尿液等各项指标均在正常值范围内 ;丹参高剂量组用药 180d ,凝血时间延长 ,高、中剂量组用药 180d ,AST明显升高 ,白蛋白降低 ;高剂量组部分动物有不同程度的肝脂肪变性及肝细胞水肿 ,但停药 2 1d基本恢复正常。结论 丹参高剂量长期应用对Beagle犬肝细胞有一定毒性 ;其无毒反应剂量大约为 2 .0g/ (kg·d) 相似文献