全文获取类型
收费全文 | 27900篇 |
免费 | 2115篇 |
国内免费 | 597篇 |
专业分类
耳鼻咽喉 | 216篇 |
儿科学 | 1061篇 |
妇产科学 | 424篇 |
基础医学 | 2814篇 |
口腔科学 | 599篇 |
临床医学 | 2883篇 |
内科学 | 3828篇 |
皮肤病学 | 462篇 |
神经病学 | 1261篇 |
特种医学 | 392篇 |
外科学 | 1645篇 |
综合类 | 2919篇 |
预防医学 | 3699篇 |
眼科学 | 4292篇 |
药学 | 3031篇 |
12篇 | |
中国医学 | 576篇 |
肿瘤学 | 498篇 |
出版年
2024年 | 75篇 |
2023年 | 428篇 |
2022年 | 1024篇 |
2021年 | 1629篇 |
2020年 | 1157篇 |
2019年 | 937篇 |
2018年 | 980篇 |
2017年 | 1012篇 |
2016年 | 1050篇 |
2015年 | 1100篇 |
2014年 | 1752篇 |
2013年 | 2177篇 |
2012年 | 1681篇 |
2011年 | 1746篇 |
2010年 | 1438篇 |
2009年 | 1352篇 |
2008年 | 1118篇 |
2007年 | 1170篇 |
2006年 | 1150篇 |
2005年 | 997篇 |
2004年 | 871篇 |
2003年 | 688篇 |
2002年 | 651篇 |
2001年 | 526篇 |
2000年 | 446篇 |
1999年 | 370篇 |
1998年 | 367篇 |
1997年 | 330篇 |
1996年 | 245篇 |
1995年 | 199篇 |
1994年 | 164篇 |
1993年 | 141篇 |
1992年 | 165篇 |
1991年 | 122篇 |
1990年 | 114篇 |
1989年 | 127篇 |
1988年 | 98篇 |
1987年 | 103篇 |
1986年 | 90篇 |
1985年 | 139篇 |
1984年 | 100篇 |
1983年 | 92篇 |
1982年 | 107篇 |
1981年 | 81篇 |
1980年 | 68篇 |
1979年 | 57篇 |
1978年 | 49篇 |
1977年 | 24篇 |
1976年 | 28篇 |
1974年 | 19篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
22.
Takahiro Namiki Chika Takano Ryoji Aoki Quang Duy Trinh Ichiro Morioka Satoshi Hayakawa 《Congenital anomalies》2022,62(1):38-41
Congenital rubella syndrome (CRS) results from maternal rubella virus infection in early pregnancy. Abnormal neuroimaging findings have been analyzed in a small number of CRS patients in the past; however, their clinical significance has been poorly addressed. Therefore, we have investigated the neuroimaging findings of 31 patients with CRS from previous studies. The most common finding was parenchymal calcification, which was observed in 18 of 31 patients (58.1%). A multivariable logistic regression model showed that it was associated with psychomotor or mental retardation (p = 0.018), suggesting that parenchymal calcification in CRS could be a prognostic factor. 相似文献
23.
Bacterial keratitis continues to be one of the leading causes of corneal blindness in the developed as well as the developing world, despite swift progress since the dawn of the “anti-biotic era”. Although, we have expeditiously developed our understanding about the different causative organisms and associated pathology leading to keratitis, extensive gaps in knowledge continue to dampen the efforts required for early and accurate diagnosis, and management in these patients, resulting in poor clinical outcomes. The ability of the causative bacteria to subdue the therapeutic challenge stems from their large genome encoding complex regulatory networks, variety of unique virulence factors, and rapid secretion of tissue damaging proteases and toxins.In this review article, we provide an overview of the established diagnostic techniques and therapeutics for keratitis caused by various bacteria. We extensively report the recent in-roads through novel tools for accurately diagnosing mono- and poly-bacterial corneal infections. Furthermore, we outline the recent progress by our groups and others in understanding the sub-cellular genomic changes that lead to antibiotic resistance in these organisms. Finally, we discuss in detail, the novel therapies and drug delivery systems in development for the efficacious management of bacterial keratitis. 相似文献
24.
25.
26.
《Surgery (Oxford)》2021,39(9):591-597
Infections of the ear, nose and throat are common. The majority of these infections are managed by the primary care physicians and they settle with conservative and medical management. However, a small group can progress to become troublesome and develop complications to the extent that they may require surgical intervention. Some of the infections can lead to life-threatening complications, therefore awareness and correct diagnosis along with appropriate management is paramount. Foreign bodies in the ear, nose and throat are commonly encountered. The location and type of foreign body can have an implication on the urgency of action and the possible complications. In this article the common ENT infections and foreign bodies and their management are discussed. 相似文献
27.
目的 分析白内障围手术期结膜囊菌群的分布及药敏试验结果。方法 选取264例白内障患者,分别在患者入院后、手术消毒前、手术消毒后、手术结束后四个时间点取样,进行细菌培养及药敏试验,比较不同时期的细菌培养结果和药敏结果。结果 入院后结膜囊细菌培养阳性率明显高于手术消毒前、手术消毒后及手术结束后;入院后结膜囊细菌培养以表皮葡萄球菌为主;革兰氏阳性球菌对头孢西丁、加替沙星、左氧氟沙星等敏感性较高。结论 表皮葡萄球菌是结膜囊最常见的细菌,术前应常规应用抗生素点眼,聚维酮碘冲洗结膜囊等来预防术后感染性眼内炎。 相似文献
28.
29.
30.
《Vaccine》2016,34(24):2663-2670
Human metapneumovirus (HMPV) is a major cause of morbidity and mortality from acute lower respiratory tract illness, with most individuals seropositive by age five. Despite the presence of neutralizing antibodies, secondary infections are common and can be severe in young, elderly, and immunocompromised persons. Preclinical vaccine studies for HMPV have suggested a need for a balanced antibody and T cell immune response to enhance protection and avoid lung immunopathology. We infected transgenic mice expressing human HLA-A*0201 with HMPV and used ELISPOT to screen overlapping and predicted epitope peptides. We identified six novel HLA-A2 restricted CD8+ T cell (TCD8) epitopes, with M39–47 (M39) immunodominant. Tetramer staining detected M39-specific TCD8 in lungs and spleen of HMPV-immune mice. Immunization with adjuvant-formulated M39 peptide reduced lung virus titers upon challenge. Finally, we show that TCD8 from HLA-A*0201 positive humans recognize M39 by IFNγ ELISPOT and tetramer staining. These results will facilitate HMPV vaccine development and human studies. 相似文献