中药组方贴敷联合非甾体抗炎药治疗亚急性甲状腺炎临床对照研究

目的对照研究中药外用贴敷联合非甾体抗炎药治疗亚急性甲状腺炎临床疗效。方法选取2015年2月～2017年7月我院就诊的162例亚急性甲状腺炎患者,将其随机分为治疗组和对照组,其中治疗组90例采用中西医结合疗法,对照组72例采用西药治疗,观察比较两组患者症状改变,检测血沉、游离三碘甲状腺原氨酸、游离甲状腺素、促甲状腺激素水平。结果治疗组和对照组总有效率为92.2%、87.5%,痊愈率分别达到74.4%、47.2%,比较差异有统计学意义(P0.05)。两组甲减发生率、亚甲炎复发率分别为7.8%、15.3%、3.0%、8.8%,比较差异有统计学意义(P0.05)。结论治疗组方案发扬中药全面调理和西药快速解除症状的双重作用。中药干预可促进甲状腺功能恢复,减轻亚甲炎炎性反应,尤其在降低复发率及甲减发生率方面有积极意义。     

Movement and mental health: Behavioral correlates of anxiety and depression among children of 6–17 years old in the U.S.

ObjectivesThe purpose of this cross-sectional study was to examine associations between physical activity, screen-time, sleep duration, and their combinations based on 24-h movement guidelines with anxiety and depression among a nationally representative cohort aged 6–17 years in the US.MethodsThe 2016 National Survey of Children's Health (NSCH) data from a representative sample of children (n = 15,010) aged 6–11 years and adolescents (n = 20,708) aged 12–17 years were analyzed using logistic regression. This analysis examined parent-reported demographics, lifestyle-related behavioral variables, adverse childhood experiences, and history of anxiety and depression.ResultsPhysical activity participation was associated with anxiety and depression. Children with 0 days/week of physical activity were about twice more likely to have anxiety (Odds ratio (OR) = 2.19), and adolescents were over twice as likely to have anxiety (OR = 2.25) and depression (OR = 2.18), than peers with daily physical activity ≥ 60 min. There was no significant difference in the ORs of anxiety or depression between the children with daily physical activity and those with physical activity ≥60 min on 1–3 days/week or 4–6 days/week. Extracurricular activity participation and sleep duration were also significantly associated with anxiety and depression along with demographic variables such as race and weight status.ConclusionSome physical activity or organized extracurricular activity participation are associated with decreased odds of experiencing anxiety among children and adolescents, and depression among adolescents. Meeting all three 24-h movement guidelines was associated with lower ORs for anxiety for children and adolescents and depression among adolescents.     

A systematic scoping review: Resources targeting the training and education of health and recreation practitioners to support physical activity among people with physical disabilities

BackgroundHealth and recreation practitioners play an important role in promoting and supporting leisure time physical activity (LTPA) among persons with physical disabilities (PWPD), yet many practitioners lack training and education to provide the basic knowledge, skills, and resources necessary.¹ Little is known about existing LTPA information and training resources for health and recreation practitioners and there has been no known systematic effort to identify existing resources.ObjectiveThe purpose of the current study was to engage systematic scoping methodologies to identify resources that target the training and education of health and recreation practitioners to promote and support LTPA among PWPD. To further analyze the identified resources, an assessment of quality was conducted.MethodsSystematic scoping review methodologies were employed, which included searches of academic and grey literature, online materials (i.e., Google search) and expert consultation. Results: Several (N = 46) resources were identified from academic, government and non-government, and professional organizations. Most resources were targeted to a specific PWPD population. The resources were of high technical quality. Conclusion: The paper serves as a listing of existing resources for practitioners working with PWPD in LTPA settings. The review provides a catalyst for action in further research and practice regarding the analysis, design, development, implementation and evaluation of optimally effective resources targeting practitioners to promote and support LTPA among PWPD.ResultsSeveral (N = 46) resources were identified from academic, government and non-government, and professional organizations. Most resources were targeted to a specific PWPD population. The resources were of high technical quality.ConclusionThe paper serves as a listing of existing resources for practitioners working with PWPD in LTPA settings. The review provides a catalyst for action in further research and practice regarding the analysis, design, development, implementation and evaluation of optimally effective resources targeting practitioners to promote and support LTPA among PWPD.     

Long-term neighborhood ethnic composition and weight-related outcomes among immigrants: The Multi-Ethnic Study of Atherosclerosis

Weight among immigrants in the United States (US) is lower than among the US-born on average, but higher among long-term immigrants than the newly arrived. Neighborhood coethnic concentration—the proportion of neighborhood residents of the same ethnic background—may influence weight among immigrants via behavioral norms and market-driven community resources. However, the relevant exposure timeframe may be far longer than is captured by existing cross-sectional and short-term studies. Using detailed historical residential address information on 1449 older Latino and Chinese long-term immigrants, we investigated associations of 10–20-year neighborhood coethnic concentration trajectories with current waist circumference and weight-related behaviors (diet, physical activity, and sedentary time). Among Chinese participants, compared to persistent low coethnic concentration, increasing coethnic concentration was associated with higher waist circumference (difference = 1.45 cm [0.51, 2.39]). In contrast, both increasing coethnic concentration and persistent high coethnic concentration were associated with a healthier diet. Among Latino participants, trajectories characterized by higher coethnic concentration were associated with higher waist circumference (e.g., difference = 2.11 cm [0.31, 3.91] for persistent high vs. persistent low) and low physical activity. Long-term patterns of neighborhood coethnic concentration may affect weight-related outcomes among immigrants in complex ways that differ by ethnicity and outcome.     

Design,synthesis, and evaluation of a series of novel phenylpropanoic acid derivatives agonists for the FFA1

Free fatty acid 1 (FFA1/GPR40) has attracted extensive attention as a novel target for the treatment of type 2 diabetes for its role in the enhancement of insulin secretion with glucose dependency. Aiming to develop novel potent FFA1 agonists, a new series of phenylpropionic acid derivatives were designed and synthesized on the basis of the modification of chemical cement of TAK‐875, AMG‐837, and LY2881835. Among them, most promising compounds 7 , 14 , and 15 were obtained with EC₅₀ values of 82, 79, and 88 nM, exhibiting a powerful agonistic activity compared to TAK‐875 (95.1 nM). During Oral glucose tolerance test in normal mice, compound 7 , 14 , and 15 had significant glucose‐lowering effect at the dose of 50 mg/kg. Furthermore, compound 15 (50 mg/kg) also significantly improved in glucose tolerance in type 2 diabetic mice. Herein, we reported the discovery and optimization of a series of potent FFA1 agonists. The discovery supported further exploration surrounding this scaffold.     

Synthesis and antiproliferative activity of new mycophenolic acid conjugates with adenosine derivatives

New conjugates of mycophenolic acid (MPA) and adenosine derivatives were synthesized and assessed as potential immunosuppressants on Jurkat cell line and peripheral blood mononuclear cells (PBMC) from healthy donors. As compared to MPA, all compounds were found to be more active against Jurkat cell line. The antiproliferative activities were compared with MPA and adenosine, in both 2′,3′-O-isopropylidene protected and free hydroxyl groups possessing forms. The obtained results were also discussed in terms of selectivity index, defined as SI = IC₅₀/EC₅₀.