A new T2 preparation technique for ultrafast gradient-echo sequence

The T₂, contrast in images obtained with driven equilibrium (90°_x?180°_x?90°_x) prepared ultrafast gradient-echo sequences is compromised by the longitudinal magnetization build-up after the second 90°_x pulse, which does not carry T₂ information. This paper describes a new T₂ contrast preparation technique for ultrafast gradient-echo sequence that suppresses the signal arising from the build-up. By dephasing in the preparation and rephasing in the acquisition of the gradient echoes, the new technique eliminates signals that are not dictated by the T₂ contrast in a driven-equilibrium approach. Consequently, it generates an image that is essentially T₂-weighted. Phantom and in vivo experiments were conducted to validate the technique and to demonstrate its clinical utility. These studies indicate that the technique works properly and can be used for in vivo studies.     

Evidence for a cytosolic inhibitor of epithelial chloride channels

It has been known for several years that the outwardly rectifying 30-pS chloride channel, the regulation of which has been reported to be defective in cystic fibrosis, can be activated by excision of a membrane patch from a cell. This suggested that the cytosol contains an inhibitory factor, which diffuses away after excision, thereby releasing the channel block. To test for such an inhibitor we have isolated cytosol from two epithelial cell lines, and in larger quantities from pig kidney cortex. Kidney cortex was chosen because published and unpublished evidence suggested that proximal tubular cells might also have a tonically suppressed Cl^– conductance in the brush-border membrane, which is activated during isolation of membrane vesicles. The inhibitory effect of the cytosol preparations was assessed by: (a) measuring conductive Cl^– fluxes on renal proximal tubular brush-border membrane vesicles preloaded with or without cytosol, and (b) recording single Cl^– channel currents from excised membrane patches of nasal polyp epithelia and CFPAC-1 cells in the presence and absence of cytosol. All cytosol preparations tested were found to inhibit both conductive Cl^– flux in membrane vesicles and single Cl^– channels in patch-clamp experiments. In the latter case a type of flicker block was observed with a reduction of channel open probability. Stepwise dilution of the cytosol consistently reduced the inhibitory potency. Since the inhibition was preserved after boiling the cytosol for 10 min, we conclude that the inhibitor is a heat-stable substance. Whether it is identical with the postulated intracellular regulator that couples the defective function of the cystic fibrosis gene product to Cl^– channel inhibition cannot be decided at present.     

2002年西安市部分医疗机构制剂状况分析

目的 :调研西安市属医疗机构制剂现状 ,分析制剂品种、产值、经济效益与医疗机构床位规模之间关系。方法 :以 2 0 0 2年度 15家医院制剂的品种、产值与床位规模作线性回归分析。结果 :各医院制剂品种与生产规模及生产效益差别很大 ,制剂产值效益与非标品种显著相关 ,而与床位规模无相关性     

均匀纺锤形α—FeOOH微晶制备过程

在过程分析的基础上，以Ｎａ２ＣＯ３作为沉淀剂，在ＦｅＳＯ４溶液中形成Ｆｅ（ＯＨ）２－ＦｅＣＯ３沉淀，通入空气氧化制备了均匀纺锤形α－ＦｅＯＯＨ微晶。研究了碱比、通气量、温度、浓度、搅拌转速以及加料方式等对制备过程以及纺缍形铁黄形态的影响规律，并制备出粒度为０．２μｍ，轴比为３～４，均匀、无枝杈的纺锤形α－ＦｅＯＯＨ粒子。实验验证了该过程为传质控制。     

液相化学沉积法制备云母钛珠光颜料

将液相化学沉积法合成云母钛珠光颜料剖析为Ｔｉ＾４＋的水解和水解产物在云母表面沉积两个过程。从Ｔｉ＾４＋的水解机理和结晶动力学两方面分析了影响云母钛合成的主要因素：反应体系的ｐＨ值，温度和Ｔｉ＾４＋浓度。对各主要因素进行了实验考察，得到了合成云母钛的较佳工艺条件，即反应体系的ｐＨ值为２．０￣２．２，反应温度为７５￣８０℃，Ｔｉ＾４＋浓度为３．１ｃ ｇ ／ｌ。同时对ＴｉＯ２在云母表面的沉积机理进行了探     

食管—胃一层吻合11例临床探讨

消化道的吻合法以往多用二、三层吻合法,本文参照近年来一些报道,将一层吻合法应用于食管、贲门癌的手术中,效果良好。作者认为一层吻合法操作简单,避免了多层吻合的并发症。     

生血素的研制及临床应用研究

本文总结了用酶水解猪血成水解液并配制成无菌口服液－生血素，临床应用于治疗儿童缺铁性盆血，取得满意的治疗效果，总有效率９４％，对消化道无副作用。     

含乳糖酶冻干酵母制剂的研究

在研制双糖酶肠溶微囊及乳糖酶复合微囊的同时,我组还研制了含乳糖酶冻干酵母,具有成本低廉而利用广、酶活性高而稳定、生产流程短而简便等优点.该冻干酵母可制备成含乳精酶冻干酵母抗酸肠溶胶囊,该抗酸肠溶胶囊置人工胃液中2h,乳糖酶剩余活性仍在60%以上;置人工肠液中lh,乳糖酶释放率达100%.     

Two Children with Bromate Intoxication due to Ingestion of the Second Preparation for Permanent Hair Waving

We report two children who suffered from sodium bromate intoxication due to ingestion of the second preparation for permanent hair waving (the second permanent preparation). One child suffered from gastrointestinal symptoms only. The other exhibited slight acute renal insufficiency. Results of the histological examination of the kidney in the sick child with acute renal insufficiency showed sporadic epithelial separation of the proximal tubuli under light microscopy. In addition, we could demonstrate more clearly epithelial separation and unbroken tubular basement membranes under electron microscopy (EM). To our knowledge, this is the first report of EM findings in this disease. The mechanism of epithelial injuries by bromate is not clear.     

乙型肝炎病毒特异性转移因子的制备及其某些性质研究

从ＨＢｓＡｇ阳性人胎盘中提取了乙型肝炎病毒特异性转移因子（ＨＢＶ－ＳＴＦ），对其各项指标进行了检测和临床试用。结果显示，我们制备的ＨＢＶ－ＳＴＦ是一种可用于治疗乙肝的安全、有效的免疫调节剂。