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61.
微量元素锌在佝偻病治疗中的效果观察 总被引:7,自引:1,他引:6
目的 :探讨补充锌 +维生素D +钙剂治疗佝偻病的效果。方法 :随机分为 3组 ,每组各 5 3例。对照组给予常规治疗 (即维生素D +钙剂 ) ,治疗 1组先给予锌治疗 1个月后 +常规治疗 ,治疗 2组同时给予锌 +常规治疗。 3个月为 1疗程。治疗前后检测血清微量元素及骨碱性磷酸酶 (BALP)等项目。结果 :治疗 1、2组疗效好于对照组 ,差异非常显著 (P <0 0 1) ;治疗1组疗效好于治疗 2组 ,差异有显著性 (P <0 0 5 )。结论 :治疗大多数伴低锌的佝偻病先补锌 1个月 ,再加常规治疗 ,疗效更佳。 相似文献
62.
目的本文主要研究硒和维生素C影响髓系与非髓系白血病细胞增殖及其细胞毒性的异同。方法体外培养髓系白血病细胞株HL60及非髓系细胞株K562,培养时分别设Se(5μm、8μm、11μm)及VitC(5μm、10μm、100μm)实验组及对照组,培养24h、48h、72h后分别取样,利用台盼蓝拒染法进行细胞计数,绘制细胞生长曲线,并通过噻唑蓝比色分析法研究Se及VitC对HL60、K562细胞毒性。结果细胞生长曲线显示:Se(5~11μm)及VitC(5~10μm)对HL60、K562细胞增殖均有抑制作用。MTT结果显示:Se(5~15μm)对两种细胞均有细胞毒性。VitC(5~10μm)对HL60具有细胞毒性,而VitC(5~100μm)对于K562,短时间内毒性作用较明显,随作用时间延长而减弱。结论本实验结果提示:Se及VitC对髓系和非髓系白血病细胞增殖均有抑制作用,但VitC对于HL60和K562作用机制是不同的。这为白血病的化学预防和临床辅助治疗提供一定的理论依据。 相似文献
63.
O. F. M. SELLEVOLD T. M. BERG K. A. REIN O. W. LEVANG O–J. IVERSEN K. BERGH 《Acta anaesthesiologica Scandinavica》1994,38(4):372-379
A prospective randomized study was performed to investigate the effect of surface coating with covalently endpoint–attached heparin (Carmeda Bio Active Surface) and reduced general heparinization on haematological indices and complement C5 activation. Care was taken to optimize the rheological design of the system using centrifugal pump and a closed system without venting or machine suction. Twenty patients scheduled for aortocoronary bypass grafting (EF > 0.5) participated in the study. Ten patients were randomized to be treated with heparin–coated equipment (CBAS) and reduced i.v. heparin (1.5 mg kg-1) while 10 patients treated with identical but noncoated equipment and full heparinization (3 mg–kg-1) served in a Control group. A vacuum suction was used to collect the blood from the operating field and it was autotransfused at weaning from extracorporeal circulation (ECC). Blood samples were obtained from the venous (precircuit) and arterial (postcircuit) side. We used a new and very specific method for detection of C5a based on monoclonal antibodies. The concentration of C5a was low in both groups during the operation but a significant increase was seen on days 1 and 2. In the Control group there was an increase from 10.2 ngml-1±1.2 to 27.5 ng ml-1 ± 4.8 on day 2 and in the CBAS group from 10.7 ng ml-1 ± 1.2 to 35.6 ng ml-1 ± 11.6 on day 2 (NS between groups). The granulocytes and total leukocyte count increased at the end of ECC and was maintained at the elevated level throughout the study period. The amount of free haemoglobin was high in the autotransfused blood in both groups. The present results confirm the feasibility of reducing general heparin when using heparin–coated systems but the study does not support the superiority of such coating with regard to biocompatibility in short procedures with a Theologically optimized circuit. The potential benefit from reduced heparin and protamine has not been fully evaluated. 相似文献
64.
A seroepidemiological study was carried out in a geographically well-defined area in rural Crete in order to determine the prevalence of A, B and C hepatitis markers in the local population. Serum samples were obtained from 257 subjects (94 males, 163 females), aged 15 years and over, who visited the primary health care services of the Spili Health Centre between July 1993 and March 1994, and from 164 subjects (83 males, 81 females) randomly selected from households in three neighbouring villages of the study area. In samples obtained from the Spili Health Centre, antibodies to hepatitis A virus (anti-HAV) were detected in 234/244 (95.9%) subjects, antibodies to hepatitis B virus core antigen (HBcAb) were detected in 63/257 (24.5%) subjects and antibodies to hepatitis C virus (anti-HCV) were detected in 28/257 (10.9%) subjects. The corresponding figures for those randomly selected from the villages were 135/154 (87.7%), 16/164 (9.8%) and 5/164 (3%) respectively. Hepatitis B surface antigen (HBsAg) was positive in three (1.2%) subjects from the first group, while none of those recruited from the villages were positive for HBsAg. Interestingly, hepatitis markers were closely associated with age. No subjects under the age of 15 years showed evidence of prior hepatitis A infection and approximately 20% of those between 15 and 44 years of age were also negative. By contrast, practically all subjects older than 44 years were anti-HAV positive. Similarly, the majority of all those who were anti-HCV positive were older subjects. Seroepidemiology of hepatitis in this well-defined population seems to be different from other parts of Greece, at least for hepatitis B and C viruses. There is a very low prevalence of HBsAg and a very high incidence of anti-HCV. Low exposure to HAV, as found in other parts of the country, was also found in the younger generation in this rural area of Crete. 相似文献
65.
Masanori Hara M.D. Reiko Yoshida M.D. Susumu Inaba M.D. Akira Higuchi M.D. Yoshifumi Suzuki M.D. Toshio Okada M.D. Takakuni Tanizawa M.D. 《Pediatrics international》1991,33(3):335-344
The aim of this study was to assess the significance of C3 deposition in IgA nephropathy in children and adolescents. One hundred and two patients aged 5–21 years (57 male and 45 female) were studied. The findings of C3 deposition were classified into 8 groups by immunofluorescent (IF) pattern and intensity as follows: group MC3+ (N = 12): mesangiocapillary pattern and 3+ in intensity; group MC2+ (N = 13): mesangiocapillary and 2+; group MC1 + (N = 4): mesangiocapillary and 1 +; group M3+ (N = 11): mesangial and 3+; group M2+ (N = 24): mesangial and 2+; group M1 + (N=18): mesangial 1 +; group S (N = 12): only segmentally positive; and group N (N = 8): negative. Histological changes were scored semiquantitatively as an activity index (cellular proliferation, necrosis, interstitial cell infiltration, and cellular crescents) and a chronicity index (mesangial sclerosis, segmental and global glomerular sclerosis, fibrous crescents, adhesion and tubulo-interstitial change). IF findings were scored semiquantitatively and laboratory findings were also studied. The following results were obtained: 1) The scores of total activity index in MC groups were higher than in the M, S or N groups, and the greater the degree of C3 deposition, the higher the score; 2) Such result was not evident in the chronicity index; 3) High IF scores of IgG and IgM were found in the MC3+ and MC2+ groups; 4) Hematuria was more severe in MC3+ and MC2+ than in other groups, and proteinuria was more prominent in the MC than other groups. Thus the degree of C3 deposition was parallel with histological activity and urinary findings. 相似文献
66.
核黄素缺乏大鼠红细胞维生素E水平的变化及脂质过氧化关系的研究 总被引:6,自引:0,他引:6
对两组大鼠分别喂饲核黄素缺乏(RD)膳和核黄素添加(R8,22mg/kg饲料)膳8周后,测定了两组大鼠的红细胞维生素E(RBLVe)、红细胞超氧化物歧化酶(SOD)和红细胞丙二醛(MDA)的水平。结果发现:RD组RBCVe水平(4.7173±0.7710mg/g蛋白质)显著低于RS组(5。3868±1.1537mg/g蛋白质,P<0.05)。而RD组的RBCSOD(7745.2±610.1u/g蛋白质)和MDA(0.6868±0.1372μg/g蛋白质)则分别显著低于和高于RS组(8268.5±301.0nu/g蛋白质,0.5548±0.0980,P<0.05)。研究提示,核黄素缺乏引起细胞膜脂质过氧化加重可能RBCVe消耗增加。 相似文献
67.
Purified secretory acetylcholinesterase (sAChE) from Trichostrongylus colubriformis was used as a candidate vaccine against mixed T. colubriformis, Haemonchus contortus and C. oncophora challenge infections of sheep. Cross species protection was achieved with an average reduction in worm burden of all species of 31%, rising to 58% in individual cases. There was no consistent reduction in faecal egg counts and increases in anti-T. colubriformis sAChE IgG antibody levels following vaccination were modest. We suggest that improved antigen delivery systems will result in increased host protection. 相似文献
68.
S. Leskinen-Kallio 《Clinical physiology and functional imaging》1994,14(3):329-335
Summary. The particular advantages of positron emission tomography (PET) technique are that it has higher sensitivity, higher resolution, and a higher quality of image than that found in conventional nuclear medicine. The possibility of quantification and the wide range of useful tracers have raised expectations of this new method. To date, most of the human PET cancer studies have been performed with [18F]fluorodeoxyglucose (FDG) or [11CJmethionine. These are good imaging agents for tumours. However, more specific radiopharmaceuticals are required if other features of tumour metabolism are to be observed, f11Thymidine may prove to be a good tracer for quantitative measurements of tumour proliferation and [18F]misonidazole has been suggested for imaging of hypoxia. 相似文献
69.
谢林 《湖南中医药大学学报》1994,14(2):1-3
本文从髌骨软骨软化症的病因病理出发,阐述了活血化瘀疗法治疗髌骨软骨软化症的作用及其原理,列举了活血化瘀法在该病治疗中的具体运用,同时强调了在辨证施治基础上活血化瘀的重要性。 相似文献
70.