基于中医传承辅助系统的预防子宫内膜异位症术后复发用药规律分析

目的 :基于中医传承辅助系统软件,挖掘CNKI、VIP、SINO-MED和万方数据库中收录的2006~2016年关于子宫内膜异位症腹腔镜术后预防复发的中成药及中药方剂的组方规律。方法:将CNKI、VIP、SINO-MED和万方数据库中预防子宫内膜异位症术后复发的方剂录入中医传承辅助系统,采用软件集成的改进互信息法、复杂系统熵聚类、无监督的熵层次聚类等无监督数据挖掘方法,分析方药的组方规律。结果:对筛选出的103首预防子宫内膜异位症术后复发处方进行分析,确定处方中药物出现的频次,演化得到核心组合49个,新处方12个。结论:通过中医传承辅助平台研究预防子宫内膜异位症术后复发的用药规律,用药频次前五位的是丹参、莪术、当归、三棱、赤芍,药物组合前三位是三棱、莪术,丹参、莪术,丹参、当归,以活血养血、祛瘀通络、调经止痛为主。     

张仲景辨治郁证特点分析

张仲景所论之郁证为广义的郁证,其包含人体脏腑经络、气血津液、饮食情志等多方面的壅滞、痞塞、蓄积、瘀结、失舒、失畅,为病机的概念,而不是单纯的情志致郁。张仲景郁证辨治特点主要体现为:辨证论治,诸法兼用;以通为治,以通为顺;注重阳气,治病求本;扶正祛邪,虚实兼顾;因势利导,予邪出路。     

中、日、韩三国中医药SCI论文计量分析

以SCIE平台为数据来源,从发文量、被引情况、语种、期刊、学科、机构、国际合作等方面,对SCIE平台收录的1996—2015年中国、日本、韩国发表的中医药领域论文进行计量分析。我国SCI论文的发文总量、被引总量大幅领先日本、韩国,篇均被引次数近年来与日本、韩国持平。超过97%的论文以英语发表。发文量Top 10期刊影响因子主要分布在1~3分左右,以替代医学、药理/药学、化学领域期刊为主。药理学/药剂学、化学、生物化学/分子生物学是中医药SCI论文发文量最大的领域,其发文量、被引次数高于替代医学。中国科学院系统、综合性大学是中医药科研的重要力量,且论文篇均被引次数普遍高于中医药院校。中国的国际合作率低于日本、韩国。国际合作论文的被引次数高于非国际合作论文的被引次数。我国中医药科研水平与日本、韩国接近,但在规模上更具优势。中药学是中医药研究领域的优势学科。与中国科学院系统、综合性大学相比,我国中医药院校的科研影响力需要进一步提高。我国中医药科研国际合作率偏低,需要加强中医药国际科研合作实力。     

Physician and nurse satisfaction with an Electronic Medical Record system

Electronic Medical Records (EMRs) are intended to support clinical activity, improve efficiency, and reduce error. Reluctance to use EMRs may exist among clinicians. The purpose of this study was to assess physician and nurse satisfaction with an Emergency Department (ED) EMR. We surveyed Emergency Medicine (EM) physicians and nurses at a large urban teaching hospital after implementation of an Emergency Department EMR. The questionnaire assessed: 1) computer background and experience; 2) perceptions regarding EMR use; and 3) concerns about impact upon quality of patient care. The clinicians find the EMR easy to use and are generally satisfied with the impact on their work. However, they report that the EMR has no positive impact on patient care. They report confusion in following the sequence of screens, and are concerned with the amount of time it takes to use the EMR and the confidentiality of patient information. Similar results were found between physicians and nurses. Nurses, but not physicians, report that they are able to finish work much faster than before implementation (p < 0.05). We were unable to correlate computer background and experience with satisfaction with an EMR. This survey suggests that EM physicians and nurses favor the use of an EMR and suggests opportunities for EMR enhancement.     

低位小切口与传统甲状腺手术治疗甲状腺良性结节的临床疗效对比研究

目的对比低位小切口与传统甲状腺手术治疗甲状腺良性结节的临床疗效。方法86例甲状腺良性结节患者为研究对象,依据随机抽签法分为观察组与对照组,各43例。对照组采用传统甲状腺手术治疗,观察组采用低位小切口手术治疗。对比两组临床指标、术后并发症发生情况及手术效果。结果观察组手术时间、住院时间、切口长度分别为(42.2±6.7)min、(3.2±0.5)d、(3.4±0.7)cm,均短于对照组的(60.1±4.7)min、(5.9±1.9)d、(5.7±1.3)cm,术中出血量(8.1±2.3)ml少于对照组的(36.2±6.1)ml,差异有统计学意义(P<0.05)。观察组术后并发症发生率11.63%低于对照组的34.88%,差异有统计学意义(P<0.05)。两组手术治疗总有效率对比,差异无统计学意义(P>0.05)。结论与传统甲状腺手术相比低位小切口手术治疗甲状腺良性结节的安全性及美观度更高,相比传统甲状腺手术治疗的效果更加显著,对于无手术禁忌的患者来说,可首选低位小切口手术治疗。     

摩梭人传统医药知识研究

目的:以世代居住于泸沽湖地区(包括云南省的永宁乡和四川省泸沽湖镇)的摩梭人为研究对象,对其传统医药知识进行调查研究。方法:本研究应用医学人类学基本原理和方法,对传统医药知识及其相关影响因素进行调查。结果:感冒、胃肠炎、风湿病、高血压和妇科疾病为当地常见病;摩梭人就医行为在医疗文化中展现其多重性、多元性;摩梭人的传统医药知识掌握在年长妇女手里;宗教在摩梭人的生老病死中扮演着重要的角色;在朴素的对疾病和病因的认识上,摩梭人的传统医药还处于巫医结合的原始阶段;摩梭人传统医药文化受多民族医药文化的影响。结论:泸沽湖地区摩梭人传统医药知识具有丰富的内涵,对传统医药知识的发掘整理具有重要的学术和现实意义。     

Toward a prostate cancer precision medicine

The promise of precision cancer medicine is that we will be able to pair clinical and genomic data to provide better and more efficient treatment for cancer care. Although the focus is on the optimal pairing of existing Food and Drug Administration–approved drugs with the patient׳s tumor, precision medicine should also help determine a patient׳s risk for disease progression. Precision medicine will hopefully also lead to improved molecular biomarkers. The specific needs for predictive biomarkers vary significantly based on cancer type. The chief aim for prostate cancer biomarker development is to help distinguish indolent from aggressive disease.