全文获取类型
收费全文 | 30738篇 |
免费 | 2196篇 |
国内免费 | 985篇 |
专业分类
耳鼻咽喉 | 177篇 |
儿科学 | 435篇 |
妇产科学 | 232篇 |
基础医学 | 2437篇 |
口腔科学 | 552篇 |
临床医学 | 2738篇 |
内科学 | 6924篇 |
皮肤病学 | 190篇 |
神经病学 | 925篇 |
特种医学 | 1941篇 |
外国民族医学 | 2篇 |
外科学 | 10137篇 |
综合类 | 3064篇 |
现状与发展 | 3篇 |
预防医学 | 674篇 |
眼科学 | 128篇 |
药学 | 1279篇 |
23篇 | |
中国医学 | 321篇 |
肿瘤学 | 1737篇 |
出版年
2024年 | 86篇 |
2023年 | 827篇 |
2022年 | 1231篇 |
2021年 | 2015篇 |
2020年 | 1790篇 |
2019年 | 1765篇 |
2018年 | 1582篇 |
2017年 | 1158篇 |
2016年 | 967篇 |
2015年 | 1209篇 |
2014年 | 2122篇 |
2013年 | 2152篇 |
2012年 | 1532篇 |
2011年 | 1699篇 |
2010年 | 1369篇 |
2009年 | 1378篇 |
2008年 | 1330篇 |
2007年 | 1261篇 |
2006年 | 1085篇 |
2005年 | 995篇 |
2004年 | 813篇 |
2003年 | 728篇 |
2002年 | 587篇 |
2001年 | 511篇 |
2000年 | 381篇 |
1999年 | 367篇 |
1998年 | 354篇 |
1997年 | 266篇 |
1996年 | 256篇 |
1995年 | 214篇 |
1994年 | 188篇 |
1993年 | 183篇 |
1992年 | 132篇 |
1991年 | 124篇 |
1990年 | 123篇 |
1989年 | 89篇 |
1988年 | 92篇 |
1987年 | 81篇 |
1986年 | 72篇 |
1985年 | 109篇 |
1984年 | 110篇 |
1983年 | 62篇 |
1982年 | 84篇 |
1981年 | 76篇 |
1980年 | 78篇 |
1979年 | 44篇 |
1978年 | 66篇 |
1977年 | 38篇 |
1976年 | 48篇 |
1975年 | 31篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
151.
淫羊藿总黄酮对肾上腺素β_1受体的特异性阻断作用 总被引:2,自引:0,他引:2
为探讨淫羊藿总黄酮(TFE)对肾上腺素受体的作用,本实验用离体兔心房肌、主动脉及豚鼠气管观察了TFE对肾上腺素全体的作用,结果TFE(0.13g/L)抑制心房肌肌力和频率,并使异丙肾上腺素(ISO)对心房肌正性频率作用的量效曲线平行右移,但无钙拮抗作用及M受体激动效应,且不影响ISO对豚鼠气管条的负性肌力作用及去甲肾上腺囊(NE)对兔主动脉条的收缩作用。提示TFE选择性阻断肾上腺素β_1受体。 相似文献
152.
食管癌切除术并发胸导管损伤的早期诊断及治疗 总被引:2,自引:1,他引:1
我院1990年至1993年共施行食管癌切除术160例,术中胸导管损伤5例,发生率为2.1%,5例中3例于术中发现并及时处理,未发生乳糜胸,另2例于术后并发乳糜胸才诊断,经早期剖胸手术治愈,本文介绍了食管癌切除术并发胸导管损伤的早期诊治体会。 相似文献
153.
The introduction of laparoscopic inguinal hernia repair (LIHR) has been controversial. A questionnaire was sent to all general surgeons in New Zealand to document the early experience with LIHR and attitudes towards it. Of the 118 replies (response rate 55%). 74 were from laparoscopic surgeons. 26 of whom had performed 564 (201 public. 363 private) LIHR (23 bilateral) until January 1994. Only nine (35%) of these surgeons had assisted an experienced surgeon before performing an LIHR. and only four (15%) were supervised by an experienced surgeon during their first case. The transabdominal preperitoneal technique of LIHR was used by 14 (54%) surgeons. the extraperitoneal technique by eight (31%), and the tronsabdominal onlny technique by four (15%). There were 29 (5%) recurrences, 17 (3%) neuropathies. seven (1.2%) conversions, four (0.7%) miijor perforations. and one (0.17%) death. Of the 26 surgeons who performed LIHR, 20 (77%) were concerned about the absence of long-term results. 14 (54%) considered that the optimal technique had not been established. 13 (50%) were concerned about the unique complications associated with LIHR. 11 (42%) were less enthusiastic about performing LIHR than previously. 10 (38%) were doubtful about its advantages, and six (23%,) were uncertain about its future and considered that it should only be performed within the context of a controlled trial. This study highlights a number of issues that need to be addressed before the role of LIHR can be determined. 相似文献
154.
The SOS chromotest is a simple short-term genotoxicity assay measuring the induction of gene sfiA in Escherichia coli K-12. The recent availability of SOS tester strains with additional mutations in DNA repair or protection systems allows testing of DNA damaging compounds for genotoxic specificity. E. coli PQ300 differs from the standard SOS tester strain PQ37 in that it contains an additional mutation in gene oxyR that renders it more sensitive to oxidative genotoxins. The generation of reactive oxygen intermediates (ROI) by hydroperoxides (H2O2, t-butyl hydroperoxide, cumene hydroperoxide), gamma-radiation, glucose oxidase, and xanthine oxidase resulted in a more vigorous SOS response in strain PQ300 compared to strain PQ37. PQ300 was also more sensitive than PQ37 for the detection of reducing agents such as ascorbic acid, cysteine, and glutathione, which also alter the redox status of the bacterial cells. However, intercalating agents (adriamycin, bleomycin, and mitomycin C) and the UV- and radiomimetic compound 4-nitroquinoline-1-oxide whose DNA damaging potential are known also to involve ROI did not show significant differences between strains PQ37 and PQ300. It is concluded that the oxyR-deficient strain PQ300 is useful for detecting certain classes of genotoxins that change the oxidative/antioxidative balance of tester bacteria in the SOS chromotest. 相似文献
155.
156.
目的探讨影响IIIA期N2非小细胞肺癌(NSCLC)预后的因素,并分析经手术治疗不同亚组病人的生存率差异。方法分析1997年1月至2000年1月146例手术治疗的IIIA期N2NSCLC病人的可能影响预后因素:病理类型、肿瘤位置、肿瘤大小、手术方式、临床N2情况,N2转移组数及个数、术后辅助治疗等,并用Kaplan-Meier曲线及Logrank检验生存率差异,Cox单因素、多因素分析各因素对生存率的影响。结果IIIA期N2NSCLC病人的3年和5年生存率分别为19.86%和14.56%。单因素分析示肿瘤位置、临床N2情况、N2转移组数及个数是影响生存率的因素;多因素分析示肿瘤大小、临床N2情况,N2转移组数和肿瘤位置影响预后。右肺下叶肿瘤单组或单个N2转移,预后最好。结论纵隔N2转移淋巴结的大小、个数和组数是影响术后生存率主要因素。手术前未发现N2转移(mN2),有1组N2转移(N2L1),N2转移数少于4个者手术治疗效果好。右肺下叶肿瘤发生单组N2淋巴结转移预后好。 相似文献
157.
158.
Combined open and laparoscopic approach to chronic pain following open inguinal hernia repair 总被引:1,自引:0,他引:1
Introduction: Chronic groin pain is the most common long-term complication after open inguinal hernia repair. Traditional surgical management
of the associated neuralgia consists of injection therapy followed by groin exploration, mesh removal, and nerve transection.
The resultant hernia defect may be difficult to repair from an anterior approach. We evaluate the outcomes of a combined laparoscopic
and open approach for the treatment of chronic groin pain following open inguinal herniorrhaphy. Methods: All patients who underwent groin exploration for chronic neuralgia after a prior open inguinal hernia repair were prospectively
analyzed. Patient demographics, type of prior hernia repair, and prior nonoperative therapies were recorded. The operation
consisted of a standard three trocar laparoscopic transabdominal preperitoneal hernia repair, followed by groin exploration,
mesh removal, and nerve transection. Outcome measures included recurrent groin pain, numbness, hernia recurrence, and complications.
Results: Twelve patients (11 male and 1 female) with a mean age of 41 years (range 29–51) underwent combined laparoscopic and open
treatment for chronic groin pain. Ten patients complained of unilateral neuralgia, one patient had bilateral complaints, and
one patient complained of orchalgia. All patients failed at least two attempted percutaneous nerve blocks. Prior repairs included
Lichtenstein (n=9), McVay (n=1), plug and patch (n=1), and Shouldice (n=1). There were no intraoperative complications or wound infections. With a minimum of 6 weeks follow up, all patients were
significantly improved. One patient complained of intermittent minor discomfort that required no further therapy. Two patients
had persistent numbness in the ilioinguinal nerve distribution but remained satisfied with the procedure. Conclusions: A combined laparoscopic and open approach for postherniorrhaphy groin pain results in good to excellent patient satisfaction
with no perioperative morbidity. It may be the preferred technique for the definitive management of chronic neuralgia after
prior open hernia repair. 相似文献
159.
160.
本文对6例慢性夹层动脉瘤的MR所见进行分析。对真腔、假腔、“双腔主动脉”、左室形态和信号对比进行了描述。强调MR非侵袭性检查的重要意义。 相似文献