思密达减少静脉用红霉素副作用疗效观察

目的:探讨思密达减少红霉素胃肠道反应的作用.方法:比较观察组和对照组出现胃肠道反应的比例.结果:观察组减轻红霉素副作用与对照组有显著性差异(P＜0.01).结论:思密达在减少红霉素静脉使用中出现的胃肠道反应是安全有效的.     

喉风散与思密达交替治疗小儿口腔炎的疗效观察及护理

目的观察双料喉风散与思密达交替用于治疗小儿溃疡性口腔炎的疗效及总结护理要点。方法将60例患儿随机分成治疗组及对照组各30例,治疗组分别给予双料喉风散及思密达,对照组则予涂1%复方龙胆紫溶液于口腔患处,观察口腔溃疡消退天数及其疗效,副作用等,并采用相应的护理措施。结果双料喉风散、思密达交替用于治疗小儿溃疡性口腔炎有效率为96.7%,对照组为57.0%,两组比较,差异有统计学意义(P<0.01);治疗组的口腔炎消退天数为(3.8±2.1)天,对照组为(6.2±3.7)天,两组比较,差异有统计学意义(P<0.01)。结论双料喉风散、思密达交替用于治疗小儿溃疡性口腔炎,明显缩短病程并无毒副作用,是治疗小儿溃疡性口腔炎的有效方法。     

桃花汤微粉剂治疗慢性腹泻临床研究

目的：观察桃花汤微粉剂治疗慢性腹泻的临床疗效;方法：治疗组53例和对照组53例分别采用桃花汤微粉剂和思密达治疗。结果：总有效率治疗组86．8％,对照组77．4％,治疗组疗效优于对照组（P〈0．05）。结论：桃花汤微粉剂治疗慢性腹泻有效。     

思密达抑制红霉素产生的胃肠道不良反应的疗效评价

目的探讨思密达在红霉素注射过程中对所产生的胃肠道不良反应的抑制效果。方法将临床确诊的110例呼吸道感染疾病患者分为两组,每组平均55例。对A组患者采用单独注射红霉素的方法进行治疗：B组患者采用先静脉注射思密达后静脉注射红霉素的方法进行治疗。对两组患者在治疗过程中出现的各种并发症和不良反应现象的人数进行比较分析。结果分析结果表明,恶心、呕吐、腹痛、腹泻是患者在治疗过程中出现的主要并发症和不良反应,B组患者出现并发症和不良反应的人数明显少于A组患者,有显著的统计学差异（P〈0．05）。结论在采用静脉注射红霉素对患者进行治疗之前冲服思密达,可对患者由于注射红霉素所产生的胃肠道不良反应起到很好的抑制效果,可以做为今后临床对该类患者进行治疗的首选方法。     

思密达联合金双歧对腹泻患儿症状改善时间和临床疗效的影响

目的探讨思密达与金双歧在腹泻患儿中的联合应用价值。方法选取我院收治的腹泻患儿,随机分成研究组和对照组。研究组给予思密达与金双歧联合治疗方案,对照组给予乳酶生和复合维生素。就两组患儿的临床症状改善时间和临床治疗效果进行比较和分析。结果与对照组患儿相比,研究组的退热时间、大便正常时间、呕吐消失时间、腹痛消失时间均显著缩短,研究组的显效率和总有效率均显著提高,分别高达86.36%和97.72%,无效率则明显降低,仅为2.28%,差别均呈现出统计学意义(P<0.05)。结论思密达联合金双歧治疗小儿腹泻可作为小儿腹泻患儿一种理想的联合用药方案,值得进一步的临床应用和推广。     

思密达和云南白药联用治疗新生儿上消化道出血临床观察

目的:观察思密达联合云南白药治疗新生儿上消化道出血的临床疗效。方法:156例上消化道出血新生儿,随机分为两组,治疗组(84例)在对照组(72例)常规治疗基础上加用思密达及云南白药。结果:治疗组总有效率(96.4%)明显优于对照组(66.3%),χ2=26.84,P<0.01,有显著性差异。结论:思密达联合云南白药治疗新生儿上消化道出血疗效明显。     

思密达联合合生元益生菌治疗小儿非感染性腹泻疗效分析

目的观察思密达联合合生元益生菌制剂治疗小儿非感染性腹泻的疗效。方法将194例0～3岁确诊为非细菌感染性小儿腹泻的住院患儿随机分为观察组和对照组,观察组采用合生元益生菌制剂与思密达联合治疗,对照组给予传统方法常规治疗。结果两组在显效率方面存在明显差异(P﹤0.05)。结论益生菌联合思密达在0～3岁小儿腹泻治疗中可显著提高疗效,值得推荐。     

干扰素联合思米达治疗手足口病口腔溃疡的护理

目的 通过对EV71致手足口病患儿的临床护理,为护理该病积累经验,探讨HFMD口腔溃疡的有效护理措施.方法 对我院2008年1月～2008年6月因感染EW/1致手足口病感染住院的208例伴口腔溃疡的198例患儿,α-1b重组人干扰素超声雾化吸入联合生理盐水漱口后,口腔溃疡局部用棉签蘸涂思米达混悬液.结果 198例口腔溃疡患儿经治疗1～2 d有效、2～4 d显效,疼痛消失、结痂,5 d内基本痊愈.208例手足口病患儿经抗病毒、对症支持治疗,全部临床治愈出院,住院时间5～31 d,平均住院(8.2±0.4)d.结论 干扰素超声雾化吸入联合思米达治疗手足口病口腔溃疡疗效好,可明显缩短病程,迅速改善症状、体征,且具有操作简便、高效、迅速、安全、易为家长及患儿接受等优点,值得推广应用.     

Therapeutic effects of smecta or smectite powder on rats with paraquat toxication

BACKGROUND:

The plasma concentration of paraquat is closely related to the prognosis of patients with paraquat toxication, and the most common cause of death from paraquat poisoning is multiple organ failure (MOF). This study aimed to evaluate therapeutic effect of smecta on the plasma concentrations of paraquat and multi-organ injury induced by paraquat intoxication in rats.

METHODS:

A total of 76 healthy adult SD rats were randomly divided into group A (control group, n=6), group B (poisoned group, n=30) and group C (smecta-treated group, n=30). Rats in groups B and C were treated intragastrically with PQ at 50 mg/kg, and rats in group A was treated intragastrically with saline (1 mL). Rats in group C were given intragastrically smecta at 400 mg/kg 10 minutes after administration of PQ, while rats in other two groups were treated intragastrically with 1 mL saline at the same time. Live rats in groups B and C were sacrificed at 2, 6, 24, 48, 72 hours after administration of PQ for the determination of paraquat plasma concentrations and for HE staining of the lung, stomach and jejunum. The rats were executed at the end of trial by the same way in group A.

RESULTS:

The plasma concentration of paraquat (ng/mL) ranged from 440.314±49.776 to 4320.6150±413.947. Distinctive pathological changes were seen in the lung, stomach and jejunum in group B. Lung injuries deteriorated gradually, edema, leukocyte infiltration, pneumorrhagia, incrassated septa and lung consolidation were observed. Abruption of mucosa, hyperemic gastric mucosa and leukocyte infiltration were obvious in the stomach. The hemorrhage of jejunum mucosa, the abruption of villus, the gland damage with the addition of inflammatory cell infiltration were found. Compared to group B, the plasma concentration of paraquat reduced (P<0.01) and the pathological changes mentioned above were obviously alleviated in group C (P<0.05, P<0.01).

CONCLUSION:

Smecta reduced the plasma concentration of paraquat and alleviated pathologic injury of rats with PQ poisoning.KEY WORDS: Smecta, Paraquat, Pathological change, Therapeutic injury     

思密达联合氧氟沙星治疗肝源性腹泻疗效分析

目的：研究思密达联合氧氟沙星治疗肝源性腹泻的疗效。方法：将３６例肝源性腹泻的病人分为两组：治疗组及对照组各１８例,治疗组应用思密达与氧氟沙量治疗,对照组应用氧氟沙星治疗。结果：治疗组总有效率是８９％,而对照组总有效率仅为３９％,Ｐ〈０．００１。治疗组疗效明显优于对照组。结论：思密达联合氧氟沙星治疗肝源性腹泻疗效显著。