银杏叶提取物注射液联合醋酸泼尼松治疗突发性耳聋的疗效观察

目的:探析银杏叶提取物注射液联合醋酸泼尼松治疗突发性耳聋的疗效。方法:选取2017年6月-2019年3月期间我院耳鼻喉科收治的96例突发性耳聋患者,按随机数表法为研究组(48例)和对照组(48例)。给予对照组醋酸泼尼松治疗,而研究组在对照组基础上增加银杏叶提取物注射液治疗,比较两组治疗效果、中医证候积分、血液流变学指标[血细胞比容(Hematocrit,HCT)、血浆黏度(Plasma Viscosity,PV)、红细胞聚集指数(Erythrocyte Aggregation Index,EAI)]以及不良反应。结果:研究组治疗总有效率较对照组更高,差异有统计学意义(P<0.05);治疗后,研究组中医证候积分、HCT、PV及EAI水平均明显低于治疗前和对照组,差异有统计学意义(P<0.05);两组均未出现不良反应。结论:银杏叶提取物注射液联合醋酸泼尼松治疗突发性耳聋安全、高效,可显著改善患者血液流变学,临床推广与应用价值较高。     

Autologous blood injection intracoronary artery for treating slow‐flow and no‐reflow in acute coronary syndrome related to primary pci

Slow‐flow and no‐reflow phenomenon are taken to sudden loss of coronary artery flow, typically after stenting or angioplasty in primary PCI. Otherwise conventional therapy, we report a technique, which autologous blood into intracoronary to supply oxygen and break process thrombosis results in successfully management no‐reflow in primary PCI in ACS.     

65例肿瘤化疗患者使用黄芪注射液后免疫功能和预后的临床观察

目的 探讨肿瘤化疗患者使用黄芪注射液后免疫功能变化的情况及预后的影响.方法 肿瘤患者65例,随机分为观察组病人33例和对照组病人32例.2组病人在常规化疗同时,观察组加用黄芪注射液静滴,动态观察2组病人的白细胞水平变化及治疗后T细胞亚群CD3 细胞、CD4 细胞、CD8 细胞和CD4 /CD8 的变化情况.结果 观察组化疗后第1～3周白细胞水平明显高于对照组(P＜0.05),白细胞波动范围观察组比对照组小;治疗后观察组患者CD3 细胞、CD4 细胞、CD8 细胞和CD4 /CD8 明显高于对照组(P＜0.05).结论 肿瘤患者在化疗同时应用黄芪注射液,能保护和促进骨髓造血能力,提高机体免疫功能,增强免疫细胞杀瘤活性,提高治疗效果.     

Efficacy and safety of Shenkang injection in the treatment of chronic renal failure: A protocol of a randomized controlled trial

Background:Chronic renal failure (CRF) is the final outcome of the development of multiple kidney diseases, and there is no effective method at home and abroad. Traditional Chinese medicine is found to play a major role in the treatment of the non-replacement stage of CRF. Shenkang injection can not only nourish the kidney, but also promote blood circulation and remove blood stasis, which is suitable for the treatment of CRF. This study aims to explore the efficacy and safety of Shenkang injection for CRF and provide evidence for clinical practice.Methods:This was a prospective randomized controlled trial. One hundred four patients with CRF were randomly divided into treatment groups and control groups according to 1:1, with 52 patients in each group. The control group received basic treatment of western medicine and the treatment group was given Shenkang injection intravenously on the basis of control group. Both groups were given standard treatment for 4 weeks with concurrent follow-up for 1 month. The outcome indicators included: total efficiency, symptom scores, creatinine clearance rate, serum creatinine, blood urea nitrogen, CystatinC, liver function, blood routine, urine routine, incidence of adverse reactions, etc. Data analysis was performed using SPSS 25.0 software.Discussion:This study will evaluate the efficacy and safety of Shenkang injection for CRF, and the results of this trial will provide clinical evidence for the treatment of CRF.Trial registration:OSF Registration number: DOI 10.17605/OSF.IO/K9C5T.     

生长抑素关节腔内注射治疗膝关节骨性关节炎的疗效观察

目的探讨生长抑素治疗膝关节骨性关节炎的疗效。方法对30例膝关节骨性关节炎患者进行关节腔内注射生长抑素750μg,每周1次,连续6周。记录治疗前后患者的VAS疼痛评分及治疗后发生的副作用,并采用林志雄评分标准评价治疗效果。结果治疗后患者疼痛明显减轻,关节综合评分优良率显著提高,没有发生严重副作用。结论生长抑素关节腔内注射治疗膝关节骨性关节炎疗效确切,副作用少,是治疗膝关节骨性关节炎的理想方法。     

自制无针粉末注射给药系统药物导入率的体外评价

目的 建立体外吸收评价方法,考察自制无针粉末注射给药系统的给药性能。方法 以人体皮肤为研究材料,荧光素钠作为模型药物,高效液相-荧光法检测,以透皮吸收率为指标,采用正交试验设计优选无针粉末注射的载药喷射参数。结果 建立的方法分析时间小于3min,在0．2304-9．216ng范围内呈线性关系,绝对回收率大于99．8％,RSD〈0．8％;自制无针粉末注射给药系统的最高透皮吸收率可达到40％,超过普通透皮途经400倍以上,与国外同类产品的药物导入效率（33％）相当;正交试验分析表明气源压力、喷管型号、药物剂量、药粉粒径均对无针粉末注射的效果有影响。结论 建立的研究方法简便、快速、准确、可靠,可用于无针粉末注射系统的体外研究;自制无针粉末注射给药系统的药物导入效率较高,值得进一步推广应用。     

超声引导下骶髂关节注射用于产后骶髂关节炎的治疗有效性研究

目的:研究超声引导下骶髂关节注射用于产后骶髂关节炎的治疗有效性.方法:选取2019年1月至2020年6月在本院接受治疗的60例产后骶髂关节炎患者,采用超声引导下骶髂关节注射治疗,观察患者治疗前后的晨僵时间、疼痛评分及治疗总有效率.结果:治疗后患者的晨僵时间明显缩短,疼痛评分显著下降(P<0.05).治疗后患者总有效率为...     

丙泊酚乳状注射液对剖宫产全身麻醉产妇血流动力和新生儿血气指标的影响

目的 研究丙泊酚乳状注射液用于剖宫产全麻的应用价值.方法 选取2018年4月至2019年6月本院产科收治的接受剖宫产手术的产妇80名,以随机数字表达法分为研究组和对照组,每组40名.对照组给予硬膜外麻醉,研究组给予丙泊酚+氯化琥珀胆碱全身麻醉.比较两组产妇血气指标及新生儿脐动静脉血气分析指标.结果 手术切皮期(T2),...     

Emotional disorder syndrome after cosmetic facial injection

There are a number of patients who develop severe anxiety or depression after receiving facial cosmetic injections. We presented a 32‐year‐old woman who developed frequent panic, tension headache, tachycardia, shortness of breath, and sleep disorder for a year after the injection of hyaluronic acid on her forehead and glabella. Brain magnetic resonance imaging (MRI) showed multiple flaky and slightly longer T1, slightly longer T2 signals on the anterior frontal white matter. However, the patient's brain MRI scan 5 months before the injection showed no such performance. The patient was asked to consult the psychiatrist and was diagnosed with anxiety disorder. We name such phenomenon by Emotional disorder syndrome after cosmetic facial injection and assume that there are three major reasons for the emergence of this syndrome. One reason may be that emotional disorder is caused by the mental state of the patient. The second reason to explain the emotional disorder might be the frontal lobe syndrome caused by the frontal embolism during the filler injection. Another reason may be leukoaraiosis, a brain white matter change which may cause depression and anxiety.