脑心通胶囊对高血压脑出血术后疗效观察

目的观察脑心通胶囊对高血压脑出血术后疗效的影响。方法采用随机对照方法将83例高血压脑出血术后病人分为观察组与对照组,对照组予常规治疗,观察组在常规治疗基础上加用脑心通胶囊治疗。疗程为28 d。记录两组治疗前及治疗后14d、28 d格拉斯哥昏迷量表(GCS)评分,治疗后3个月格拉斯哥预后量表(GOS)评分以及治疗前后血液流变学多项指标的测定结果。结果治疗后两组病人GCS评分均有改善,但治疗后28 d观察组GCS评分与对照组比较统计学意义(P<0.01);治疗后3个月观察组显效率为65.1%优于对照组的42.5%(P<0.05);治疗后28 d观察组全血高切、低切黏度较对照组有显著性改善(P<0.05或P<0.01)。治疗期间未见不良反应发生。结论脑心通胶囊治疗高血压脑出血术后病人具有改善脑部血液循环,促进受损脑组织恢复的作用。     

颞极和外囊白质高信号对CADASIL诊断价值的meta分析

目的:通过meta分析评价颞极和外囊白质高信号(white matter hyperintensities, WMHs)对诊断伴皮质下梗死和白质脑病的常染色体显性遗传脑动脉病(cerebral autosomal dominant arteriopathy with subcortical infarcts and l...     

通心络胶囊对原发性高血压病病人内皮功能的影响

目的探讨通心络胶囊对原发性高血压病病人内皮功能的影响。方法选取高血压病病人72例,随机分为常规治疗组(36例)及通心络组(36例),两组用药疗程均为8周。实验前后分别测定血清一氧化氮(NO)、内皮素(ET)及血清脂蛋白,并采用超声测量肱动脉血流介导的舒张反应(EDD)。结果两组治疗后血清NO,EDD较治疗前明显升高,血清ET浓度下降(P<0.05)。与常规治疗组相比,通心络组NO,EDD治疗后升高更显著(P<0.05)。结论常规降压治疗基础上应用通心络胶囊可进一步改善高血压病病人的内皮舒张功能。     

脑心通胶囊对冠心病无症状心肌缺血病人血管内皮依赖性舒张功能的影响

目的探讨脑心通胶囊治疗冠心病无症状心肌缺血(SMI)的疗效及其对血管内皮依赖性舒张功能的影响。方法随机将68例冠心病SMI病人分为两组,治疗组35例在常规药物治疗基础上加用脑心通胶囊治疗,对照组33例仅用常规药物治疗。治疗前后进行动态心电图及彩色多普勒超声检测,对缺血及血管内皮依赖性舒张功能的相关指标作对比观察。结果两组治疗12周后S,T段压低伴有症状的次数及其持续时间与无症状的ST段压低及其持续时间均有明显减少及缩短,与治疗前比较有统计学意义(P<0.05或P<0.01),治疗后两组比较也有统计学意义(P<0.05)。治疗组治疗后血管内皮依赖性舒张功能指标明显改善(P<0.01),与对照组比较差异亦有统计学意义(P<0.01)。用药期间病人无严重不良反应。结论脑心通胶囊对冠心病无症状心肌缺血有显著疗效,且能改善血管内皮依赖性舒张功能。     

2009年消化内镜临床研究进展回顾

现代消化内镜技术是微创医学的重要领域。2009年是消化内镜技术取得长足发展的一年。新方法和新技术的运用丰富了消化内镜学科体系。在此,回顾2009年消化内镜研究领域的重要进展,希望能为今后的工作带来启发,以进一步提高我国消化内镜的操作水平和科研水平。     

桑银降糖胶囊在体外对猪胰岛细胞增殖及分泌功能的影响

目的观察桑银降糖胶囊对体外培养猪胰岛细胞分泌功能的影响。方法体外分离纯化猪胰岛细胞进行单层细胞培养,链脲霉素（STZ）处理后分别与桑银降糖胶囊及其组分桑叶多糖、牛磺酸、银杏黄酮等共同孵育24、48 h,用放射免疫法检测培养液中胰岛素、C肽水平;光镜下观察细胞形态变化;MTT法检测胰岛细胞增殖情况。结果与其他组分比较,桑银降糖胶囊可明显提高培养液中胰岛素、C肽水平,胰岛β细胞数目明显增多。结论桑银降糖胶囊可减轻STZ对胰岛β细胞的损伤,促进胰岛细胞增殖,并使损伤的胰腺恢复正常功能,增强胰岛素的分泌功能。     

水飞蓟素胶囊联合多烯磷脂酰胆碱治疗非酒精性脂肪性肝炎的疗效观察

目的探讨水飞蓟素胶囊联合多烯磷脂酰胆碱对非酒精性脂肪性肝炎(NASH)的临床疗效。方法 80例NASH患者被随机分成2组,观察组采用当飞利肝宁胶囊联合易善复口服治疗,对照组仅采用易善复治疗,于治疗前及治疗8周后观察患者症状、肝功能、血脂、血糖及肝脏彩超变化。结果观察组症状改善情况优于对照组(P0.01或P0.05);两组丙氨酸氨基转移酶、天冬氨酸氨基转移酶、总胆固醇降低,肝脏脂肪变性改善,但观察组改善更明显;两组患者总胆固醇水平降低,观察组明显优于对照组(P0.01)。结论当飞利肝宁胶囊联合易善复治疗非酒精性脂肪性肝炎具有较好的临床疗效,能够有效改善NASH患者的临床症状、肝功能、血脂、血糖及其肝脏影像学变化。     

松龄血脉康联合瑞舒伐他汀治疗H型高血压颈动脉粥样硬化疗效观察

目的 观察松龄血脉康联合瑞舒伐他汀治疗H型高血压患者颈动脉粥样硬化的疗效.方法 入选2011-2013年我院神经内科、心血管内科门诊及病房确诊的168例H型高血压患者,随机分为治疗组86例和对照组82例.两组均口服瑞舒伐他汀片（10 mg,每晚1次）和苯磺酸氨氯地平片联合叶酸片（5 mg/0.4 mg,1次/d）,治疗组在此基础上加用松龄血脉康胶囊治疗（1.5 g/次,3次/d）,观察12个月.两组采用相同方法测量血压,治疗前、后分别检测患者颈动脉内膜-中膜厚度（IMT）、血清同型半胱氨酸（Hcy）值、血压和血脂等.结果 对照组治疗后IMT值[（1.16±0.16）mm比（1.27±0.23）mm]和颈动脉异常率[60％比69％]均有所下降;治疗组治疗后IMT值[（1.08 ±0.13）mm比（1.30±0.21）mm]和颈动脉异常率[52％比70％]较治疗前下降更为明显（P均＜0.05）,两组相比差异均有统计学意义（P＜0.05）.结论 松龄血脉康联合瑞舒伐他汀较单用瑞舒伐他汀治疗H型高血压患者颈动脉粥样硬化（CAS）有更好的临床疗效.     

Tips for anatomical hepatectomy for hepatocellular carcinoma by the Glissonean pedicle approach (with videos)

Couinaud described three fundamental approaches at the hepatic hilus in liver surgery. The Glissonean pedicle approach at the hepatic hilus is one of these procedures and provides anatomical hepatectomy for hepatocellular carcinoma (HCC). The Glissonean pedicle approach was introduced by Couinaud and Takasaki in the early 1980s. The key of the Glissonean pedicle approach is clamping the pedicle first, secondly confirming the territory, which includes the HCC, and finally dissecting the liver parenchyma. This procedure prevents intrahepatic metastasis of HCC, which spreads along the portal vein and improves the overall survival after surgery. Another key feature is that we do not have to consider any variations of the vascular elements in the hepatoduodenal ligament under the hilar plate. This procedure allows an approach to the tertiary branches, which feed a smaller anatomical area than Couinaud's segment. We refer to this area as a cone unit of the liver. The procedure is also available in laparoscopic hepatectomy and provides new knowledge of the surgical anatomy, especially for small anatomical liver resection in the cirrhotic liver.     

Immunohistochemical and clinical evaluation of cathepsin expression in soft tissue sarcomas

Lysosomal proteases are known to enhance the spread of epithelial tumour cells, but little is known of the possible role of proteases in the growth of soft tissue sarcomas (STS). We investigated the expression of cathepsins D, B, S, H, L and procathepsin L in frozen sections of 34 STS from 34 patients by immunohistochemistry (IHC). Cathepsins D, B and H were relatively highly expressed in STS (77–91%). The expression rate of cathepsins S and L and of procathepsin L was lower (40–66%). Cathepsin S and L expression showed a moderate (P = 0.078 andP = 0.019) and procathepsin L a strong (P = 0.00001) correlation with the survival rate of STS patients. Cathepsin S expression is also correlated with the local recurrence rate (P < 0.01). Lysosomal proteases may play a role in STS progression, and cathepsin expression may also have, significance as a prognostic factor in STS.