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991.
992.
L L Adcock 《Gynecologic oncology》1979,8(2):152-163
A total of 124 patients, who had prior pelvic irradiation, had radical hysterectomy performed at the University of Minnesota Hospitals from 1939 to 1977. The patients fall into two groups: those who had pelvic radiation and radical hysterectomy as primary therapy and those who had radical hysterectomy for postradiation persistent or recurrent cancer of the cervix. A major objective of this report is to describe the incidence, management, and long-term follow-up of patients with complications. Pelvic irradiation followed by radical hysterectomy as primary therapy for cancer of the cervix cannot be justified because of the high risk of urinary tract complications, some of which eventually result in demise of the patient. Radical hysterectomy for postradiation persistent or recurrent cancer is an acceptable procedure for early disease. It would appear from this experience that many patients with small cervical or vaginal postradiation neoplasms can be successfully managed with more conservative procedures such as simple hysterectomy and partial vaginectomy. The value of pelvic lymphadenectomy was not demonstrated. Exenterative procedures are becoming more frequently indicated for eradication of malignancies, with a reduction of long-term urinary tract complications. 相似文献
993.
Hanae Ouaddari Dounia Beqqour Jamal Bennazha Iz-Eddine El Amrani Abderrahman Albizane Abderrahim Solhy Rajender S. Varma 《Sustainable Chemistry and Pharmacy》2018
Natural Moroccan clay samples from different regions were purified via simple washing, activated and extensively analyzed by various characterization techniques. A comparative study of these clays as recyclable heterogeneous catalysts for the Knoevenagel condensation was undertaken in EtOH/water as solvent under mild conditions; high yield of the desired α,β-unsaturated products was obtained in a short reaction period (~ 30 min). The recyclable solid catalyst was effective for several runs indicating that these purified clays are potentially eco-friendly heterogeneous catalysts; assorted α,β-unsaturated carbonyl compounds were synthetized in high yields (~ 98%) at 40 °C. 相似文献
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995.
Jay S. Shavadia Minh N. Vo Kevin R. Bainey 《The Canadian journal of cardiology》2018,34(12):1564-1572
Coronary calcification often complicates atherosclerosis. With an aging population, coinciding with lower thresholds for coronary angiography and percutaneous coronary intervention (PCI), severe calcific coronary stenoses remain a challenge for interventional cardiologists. Although advances in coronary guidewires, percutaneous balloons, and adjunctive procedural devices have improved success of PCI, recalcitrant calcified lesions not amenable to the conventional technique frequently occur. Coronary atherectomy with plaque modification provides a therapeutic alternative. As such, various modalities such as rotational, orbital or laser atherectomy, and more recently shockwave lithoplasty have become therapeutic options for PCI. We provide a summary of the principles, technique, and contemporary evidence for these currently approved devices designed to treat severe coronary calcific lesions. 相似文献
996.
Affidah Sabran Endang Kumolosasi Ibrahim Jantan Jamia Azdina Jamal Norazrina Azmi Malina Jasamai 《Saudi Pharmaceutical Journal》2021,29(1):73-84
BackgroundPhytoestrogens are polyphenolic plant compounds which are structurally similar to the endogenous mammalian estrogen, 17β-estradiol. Annexin A1 (ANXA1) is an endogenous protein which inhibits cyclo-oxygenase 2 (COX-2) and phospholipase A2, signal transduction, DNA replication, cell transformation, and mediation of apoptosis.ObjectiveThis study aimed to determine the effects of selected phytoestrogens on annexin A1 (ANXA1) expression, mode of cell death and cell cycle arrest in different human leukemic cell lines.MethodsCells viability were examined by MTT assay and ANXA1 quantification via Enzyme-linked Immunosorbent Assay. Cell cycle and apoptosis were examined by flow cytometer and phagocytosis effect was evaluated using haematoxylin-eosin staining.ResultsCoumestrol significantly (p < 0.05) reduced the total level of ANXA1 in both K562 and U937 cells and genistein significantly (p < 0.05) reduced it in K562, Jurkat and U937 cells, meanwhile estradiol and daidzein induced similar reduction in U937 and Jurkat cells. Coumestrol and daidzein induced apoptosis in K562 and Jurkat cells, while genistein and estradiol induced apoptosis in all tested cells. Coumestrol and estradiol induced cell cycle arrest at G2/M phase in K562 and Jurkat cells with an addition of U937 cells for estradiol. Genistein induced cell cycle arrest at S phase for both K562 and Jurkat cells. However, daidzein induced cell cycle arrest at G0/G1 phase in K562, and G2/M phase of Jurkat cells. Coumestrol, genistein and estradiol induced phagocytosis in all tested cells but daidzein induced significant (p < 0.05) phagocytosis in K562 and Jurkat cells only.ConclusionThe selected phytoestrogens induced cell cycle arrest, apoptosis and phagocytosis and at the same time they reduced ANXA1 level in the tested cells. The IC50 value of phytoestrogens was undetectable at the concentrations tested, their ability to induce leukemic cells death may be related with their ability to reduce the levels of ANXA1. These findings can be used as a new approach in cancer treatment particularly in leukemia. 相似文献
997.
998.
999.
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Daniel J. Garry 《Journal of cardiovascular translational research》2008,1(4):273-277
Scientific revolutions require a series of paradigm shifts that are promoted by a series of discoveries. These discoveries,
paradigm shifts, and scientific revolutions are dependent on timing, environment, and innovative pioneers. More than 50 years
ago, a series of discoveries led to such a paradigm shift at the University of Minnesota which in turn revolutionized the
field of cardiovascular medicine forever. Today, this spirit of innovation and discovery is alive and thriving at the Lillehei
Heart Institute at the University of Minnesota. 相似文献