利福霉素产生菌1074-105#菌株的选育

利福霉素是Sensi,P. 等于1957年首次从地中海诺卡氏菌发酵液中分离出的一类抗生素,其最显著的生物活性是对革兰氏阳性细菌和分枝细菌有抑制作用,其半合成产物之一的利福平是治疗结核病的口服广谱抗生素。我厂自1989年生产利福霉素以来,生产菌株的SV发酵效价一直徘徊在4200μ/ml左右。我们从90年9月份开始,对原生产菌株进行紫外线诱变及抗自身代谢物突变筛选,得到了产量正变株1074-105~#。本文报道     

18F-SynVesT-1 positron emission tomography in a hypothalamic hamartoma with abnormal uptake

Hypothalamic hamartomas (HHs) are uncommon benign lesions of neuronal and glial cells in the inferior hypothalamus. They have been linked to epilepsy, premature puberty, and cognitive and behavioral impairment. We report a 13-year-old patient who was referred to a multidisciplinary treatment team for epilepsy with 6 months of convulsive seizures. Sustained seizure control was not achieved despite the use of multiple antiepileptic agents. He had been plagued by unexplained paroxysmal bursts of laughter for >11 years. Video-electroencephalography showed diffuse epileptic discharges prominent in the right hemisphere in both interictal and ictal phases. Magnetic resonance imaging demonstrated an isointense gray matter mass on the right lateral walls of the third ventricle, with focal hypometabolism on ¹⁸F-fluorodeoxyglucose positron emission tomography (PET). The patient subsequently was enrolled in a clinical trial of ¹⁸F-SynVesT-1 PET in epilepsy, and an increased ¹⁸F-SynVesT-1 uptake was noted in the mass. After excluding hormonal abnormalities, the patient underwent open resection targeting HHs. We used ¹⁸F-SynVesT-1 as a specific PET tracer for synaptic vesicle glycoprotein 2A, which is ubiquitously expressed in brain synapses. ¹⁸F-SynVesT-1 PET may hold promise as a supplementary tool in the presurgical localization and evaluation of HHs.