Effects of denervation and reserpine on nexuses in the rat vas deferens

Permanganate-fixed vasa deferentia from rats were examined for the presence of nexal-like contacts by electron microscopy. There was a significantly greater incidence of nexuses (2×) in chronically denervated tissues (5–7 days) but not in tissues from reserpine-pretreated animals (1.0 mg/kg/day for 5–7 days). The results suggest that an increase in nexal regions may not be a general feature of postjunctional supersensitivity but rather may contribute to other denervation-induced changes in contractile response.     

Reserpine can confer stress tolerance and lifespan extension in the nematode <Emphasis Type="Italic">C. elegans</Emphasis>

Though the lifespan extension mechanism is partly understood from C. elegans to mice, a viable pharmacological intervention is not yet feasible. Here, we report that reserpine largely known as an antipsychotic-antihypertensive drug, can extend C. elegans lifespan. Chronic reserpine treatment from embryo stage or young adults extends the C. elegans lifespan robustly at 25 degrees C. Most importantly, the reserpine treated long lived worms are active (locomotion and pharyngeal pumping) for a long time thereby conferring high quality throughout life. Reserpine mediated lifespan extension is independent of the daf-16 pathway and partly requires serotonin. Reserpine treatment makes the worms highly thermotolerant. Thus, in addition to its known function, reserpine is able to provide stress tolerance and lifespan extension in C. elegans.     

抗高血压治疗对大鼠慢性肾衰的影响

本文研究抗高血压药物治疗对５／６肾切除慢性肾衰ＳＤ大鼠的作用。所有大鼠随机分为四组，即正常对照组（Ｓｈａｍ）、５／６肾切除组（５／６Ｎｘ）、５／６肾切除＋依那普利组及５／６肾切除＋利血平、肼苯达嗪及双氢克尿噻三联高血压治疗组。结果示两种方法将血压控制在正常水平的条件下，５／６Ｎｘ大鼠尿蛋白排泄量、肾功能进行性恶化、肾小球面积及肾小球硬化病变均有不同程度的改善。提示抗高血压治疗－血管紧张素转换酶抑制