全文获取类型
收费全文 | 222671篇 |
免费 | 28817篇 |
国内免费 | 7574篇 |
专业分类
耳鼻咽喉 | 1727篇 |
儿科学 | 2059篇 |
妇产科学 | 5235篇 |
基础医学 | 16231篇 |
口腔科学 | 2185篇 |
临床医学 | 18657篇 |
内科学 | 21473篇 |
皮肤病学 | 1494篇 |
神经病学 | 871篇 |
特种医学 | 7094篇 |
外国民族医学 | 253篇 |
外科学 | 34240篇 |
综合类 | 28559篇 |
现状与发展 | 38篇 |
一般理论 | 3篇 |
预防医学 | 10821篇 |
眼科学 | 120篇 |
药学 | 15939篇 |
147篇 | |
中国医学 | 5309篇 |
肿瘤学 | 86607篇 |
出版年
2024年 | 713篇 |
2023年 | 4592篇 |
2022年 | 9088篇 |
2021年 | 11846篇 |
2020年 | 11000篇 |
2019年 | 9930篇 |
2018年 | 9624篇 |
2017年 | 10005篇 |
2016年 | 10680篇 |
2015年 | 12435篇 |
2014年 | 18070篇 |
2013年 | 17769篇 |
2012年 | 14459篇 |
2011年 | 14602篇 |
2010年 | 10694篇 |
2009年 | 11025篇 |
2008年 | 11294篇 |
2007年 | 10528篇 |
2006年 | 9304篇 |
2005年 | 7631篇 |
2004年 | 6301篇 |
2003年 | 5256篇 |
2002年 | 4383篇 |
2001年 | 4052篇 |
2000年 | 3402篇 |
1999年 | 2862篇 |
1998年 | 2430篇 |
1997年 | 2144篇 |
1996年 | 1744篇 |
1995年 | 1673篇 |
1994年 | 1409篇 |
1993年 | 1084篇 |
1992年 | 998篇 |
1991年 | 879篇 |
1990年 | 683篇 |
1989年 | 617篇 |
1988年 | 569篇 |
1987年 | 465篇 |
1986年 | 350篇 |
1985年 | 430篇 |
1984年 | 365篇 |
1983年 | 227篇 |
1982年 | 271篇 |
1981年 | 247篇 |
1980年 | 241篇 |
1979年 | 169篇 |
1978年 | 118篇 |
1977年 | 105篇 |
1976年 | 96篇 |
1975年 | 60篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
81.
Andreas Blana Stefan Denzinger Markus Lenhart Wolf F Wieland Roman Ganzer 《International journal of urology》2007,14(5):450-451
We report a case of recurrent inguinal lymphocele formation after inguinal lymphadenectomy treated by lymphographic mapping and selective ligation of the lymphatic vessels. Lymphographic mapping was performed by puncturing a lymphatic vessel at the dorsum of the foot. After isolating the vessels that drained into the lymphocele, they were clipped and divided through a small skin incision. The described technique showed an instant and complete suspension of the lymph secretion with subsequent complete healing. Lymphatic mapping and selective ligation of afferent lymphatic vessels proved to be an effective treatment of a recurrent inguinal lymphocele. 相似文献
82.
83.
Keishi Kashibuchi Kyoichi Tomita Jack A Schalken Haruki Kume Takumi Takeuchi Tadaichi Kitamura 《International journal of urology》2007,14(9):789-794
OBJECTIVES: To determine the value of the loss of expression of E-cadherin and cadherin associated molecules as useful markers for both prognosis and chemosensitivity in bladder cancer patients who have undergone radical cystectomy. PATIENTS AND METHODS: In 55 paraffin embedded specimens of radical cystectomy at our hospital from 1982 to 2000, the expression of E-cadherin, alpha-, beta- and gamma-catenin was examined by immunohistochemical staining. To evaluate the prognostic significance of these molecules, Kaplan-Meier survival curves were constructed and a statistical analysis was calculated by a log-rank test. A multivariate test (tumor stage, tumor grade, lymph node metastasis, configuration, the expression of E-cadherin, alpha-, beta- and gamma-catenin) was performed to detect prognostic markers. RESULTS: Normal expression was found in 33 cases (60.0%) for E-cadherin, 29 (52.7%) for alpha-catenin, 31 cases (56.4%) for beta-catenin, and 31 cases (56.4%) for gamma-catenin. The expression patterns for E-cadherin, alpha-, beta- and gamma-catenin were significantly correlated with each other (P < 0.01). Survival analysis showed a significant difference between normal and aberrant expression in each staining. A multivariate analysis revealed that the expression of alpha- catenin was an independent prognostic factor (P = 0.0191). In 23 patients that received adjuvant chemotherapy, there was a significant difference in survival between the normal and aberrant expression of alpha-catenin, but not other molecules. CONCLUSION: Alpha-catenin may not only be a good prognostic marker, but also one of key molecules that determine the chemosensitivities in patients with invasive bladder cancer. 相似文献
84.
Permanent prostate brachytherapy for Japanese men: Results from initial 100 patients with prostate cancer 总被引:1,自引:1,他引:0
Toshikazu Okaneya Shuji Nishizawa Tsuyoshi Nakayama Takayuki Kamigaito Iwao Hashida Noriko Hosaka 《International journal of urology》2007,14(7):602-606
OBJECTIVE: To evaluate the initial results of brachytherapy for prostate cancer with permanent iodine-125 implant in Japan. METHODS: The results obtained with brachytherapy in the initial 100 Japanese patients treated at Nagano Municipal Hospital were reviewed. Patients with a prostate-specific antigen (PSA) level of less than 10 ng/mL and a Gleason's scores of 5, 6, 3 + 4 were classified as having a low risk of recurrence. Patients with a PSA level of 10-20 ng/mL and/or a Gleason's score of 4 + 3 were classified as having an intermediate risk for recurrence. Seventy-eight of the low-risk patients and 19 of the intermediate-risk patients were treated by seed implants alone, or seed implants combined with preceding external radiation, respectively. A total of 53 patients received neoadjuvant hormone therapy. The efficacy and morbidity of brachytherapy were investigated using the serum PSA, International Prostate Symptom Score, quality of life score and uroflowmetry data. RESULTS: The average V100 and D90 obtained by post-implant dosimetry was 94.3 and 113.7%, respectively. Serum PSA decreased gradually after treatment, although it had still not reached a nadir after 1 year. There was little difference of the PSA level between the patients with and without neoadjuvant hormone therapy even at 1 year after seed implantation. There were no PSA biochemical failure or clinical recurrence during the follow-up period. Voiding symptoms worsened until 3 months after treatment, and then gradually improved. Acute urinary retention occurred transiently in one patient (1%). Rectal bleeding and severe diarrhea did not occur. CONCLUSION: Brachytherapy is a feasible and effective option for the treatment of prostate cancer in Japanese men. Brachytherapy may have a different effect in Japanese patients with respect to voiding symptoms. Urinary retention was rare, but voiding symptoms were persistent in Japanese patients. Neoadjuvant hormone therapy deserves investigation to determine whether it can achieve better results, especially in patients with an intermediate risk. 相似文献
85.
86.
87.
Takayuki Murakami Atsushi Komiya Kunihisa Mikata Shigeki Kaneko Ichiro Ikeda 《International journal of urology》2007,14(3):240-241
Abstract: A 66-year-old man was referred to our hospital with chest discomfort and shortness of breath. Seven months previously he had undergone a laparoscopic left nephroureterectomy for a left renal pelvic tumor and was given two cycles of adjuvant chemotherapy (methotrexate, epirubicin and cisplatin). Echocardiogram showed an 8-mm sized mass extending from the right atrium into the right ventricle. On computed tomography, multiple lung tumors, as well as the right atrial and ventricular mass, were seen. The patient died of acute heart failure caused by right ventricular outflow obstruction. On autopsy, a right atrial and ventricular metastasis of the initial transitional cell carcinoma was found. The patient's cause of death was acute heart failure as a result of cardiac metastasis of his initial renal pelvic carcinoma. 相似文献
88.
Wing‐Hong Li Moon‐Tong Cheung Candace N.S. Ho Ting‐Pong Fung Kai‐Ming Ko Kelvin K.W. Yau 《Surgical Practice》2007,11(4):138-143
Aim: To examine the survival benefit of liver and lung resection for colorectal metastasis and the potential prognostic factors that affect patient survival. Methods: All patients who had resection of lung or liver metastasis for colorectal metastasis in Queen Elizabeth Hospital, Hong Kong from 1995 to 2004 were retrospectively reviewed. The overall and disease‐free survival was analysed, in particularly between liver and lung metastasis. All factors that may have affected the survival were entered into Cox's proportional hazards regression model to identify significant variables associated with survival. Results: At 5 years, the overall survival of patients who had resection of lung and liver metastasis was 44% and 38%, respectively; the disease‐free survival was 26% and 24%, respectively. Overall and disease‐free survival of patients with resection of lung metastasis was comparable to those with resection of liver metastasis. The differentiations of primary tumour and time to metastasis were shown to be significant prognostic factors influencing overall survival. Those patients with systemic chemotherapy after resection of colorectal metastasis demonstrated a significantly higher probability of overall survival. Conclusion: Resection of lung and liver metastases from colorectal origin was safe and both procedures improved survival. The use of chemotherapy after resection of metastasis significantly improved the overall survival. 相似文献
89.
后腹腔镜下离断式肾盂成形术 总被引:2,自引:0,他引:2
目的探讨后腹腔镜下肾盂成形术的临床疗效. 方法腹腔镜下通过后腹腔途径对9例肾盂输尿管连接部狭窄行离断式肾盂成形术并对技术进行改进. 结果 9例手术均获成功,手术时间110~240 min,平均160 min.术中出血量30~80 ml,平均50 ml.术后住院8~18 d,平均11.2 d.术后并发症:皮下气肿(合并阴囊气肿)1例,漏尿2例.术后1~10个月B超示术侧肾盂无积水5例,轻度积水2例,中度积水2例.3例术后5个月IVU显示吻合口通畅. 结论后腹腔镜肾盂成形术微创、效果好,值得推广. 相似文献
90.
目的 探讨肝癌介入治疗与部分脾动脉栓塞同时进行的疗效。方法 对18倒不能手术切除且经B超或CT确诊,脾肿大并有WBC、PLT明显低于正常的肝癌患者行PSE TACE或经导管肝动脉化疗(TAI)介入治疗,记录治疗前后WBC、PLT、甲胎蛋白(AFP)数值进行分析。结果 栓塞后3天、7天、60天WBC、PLT值明显升高,AFP值明显下降,临床症状明显改善。结论 PSE TAI或TACE治疗肝癌并脾功亢进是一种行之有效的办法。 相似文献