布洛芬口服液的稳定性研究

目的：通过考察布洛芬口服液的稳定性,确定其有效期。方法：在不同温度、湿度和时间下,取样检测其性状、pH值、含量的变化。结论：通过检测结果确定布洛芬口服液在不同温度、湿度条件下贮存的有效期。     

反相高效液相色谱法测定抗病毒口服液中绿原酸和连翘苷含量

目的建立同时测定抗病毒口服液中绿原酸和连翘苷的反相高效液相色谱（RP—HPLC）法。方法采用岛津Shim-pack VP—ODS色谱柱（150mm×4．6mm,5μm）,流动相为乙腈（A相）-0．02％醋酸（B相）,0～20minA相的比例从5％线性增加至25％,流速为1mL／mim,检测波长为280nm。结果绿原酸和连翘苷均能良好分离,绿原酸质量浓度线性范围是0．116～1．160μmL,连翘苷质量浓度线性范围是0．65～6．50μg／mL,平均加样回收率分别为99．18％和99．36％,RSD分别为0．29％和0．20％（n=6）。结论RP—HPLC法简便、准确、重现性好．能排除其他成分的干扰．可用于该制剂的盾号控制．     

我院门诊口服钙制剂临床应用分析

目的评估口服钙制剂的临床应用情况。方法对医院2007年11月至2008年1月口服钙制剂的门诊处方进行统计分析。结果口服钙制剂的临床应用广泛,女性与中老年人使用尤多,补钙现象普遍。结论钙制剂有过度使用的趋势,补钙需谨慎。     

复方福尔可定治疗慢性阻塞性肺疾病临床观察

目的：观察复方福尔可定对慢性阻塞性肺疾病（COPD）急性发作的止咳、化痰效果。方法：50例COPD急性加重期患者。除常规抗炎、止喘、祛痰等治疗外,加复方福尔可定10ml,4次/日,口服治疗作为主要止咳、化痰药。48例COPD急性加重患者作为对照。结果：加用复方福尔可定治疗止咳化痰效果显著,咳嗽症状病程缩短。结论：复方福尔可定可作为COPD急性期常规止咳、化痰主要药物。     

强氧化水对口腔内细菌数量影响的临床试验

目的采用自身对照和细菌鉴别定量分析的方法研究强氧化水溶液对口腔内的细菌数量的影响。方法 15名志愿者分别在两个时间点含漱生理盐水和强氧化水,并分别在含漱前后采集细菌样本,送实验室细菌培养、定量分析。结果从志愿者口腔中检出的细菌主要是链球菌和奈瑟氏菌。生理盐水组和强氧化水组含漱后细菌数量均有显著减少（P=0.0014,P=0.0000）。生理盐水组和强氧化水组含漱后细菌减少程度比较有显著性差异（P=0.0051）。结论强氧化水口腔含漱可有效减少口腔内的细菌数量,其抗菌效果优于生理盐水。     

An observational study of physiotherapists’ use of cognitive-behavioural principles in the management of patients with back pain and neck pain

Objectives

This study investigated the extent to which physiotherapists collaborating in a randomised trial comparing the McKenzie approach with a Solution Finding Approach (SFA) for back pain or neck pain involved patients in the consultation, and empowered patients to develop self-management strategies. The aims were to develop a tool for this purpose and to identify any observed differences between the consultations in these two approaches.

Design

An observational study, conducted within a randomised trial (McKABI trial).

Setting

Patients referred to seven National Health Service physiotherapy departments in West and East Yorkshire.

Participants

The observational study collected data from 10 of the 28 physiotherapists participating in the McKABI trial.

Main outcome measures

The involvement and empowerment scales of the Involvement and Empowerment of Patients in Physiotherapy Assessment Rating Tool (IMPART).

Results

Although not widely used, physiotherapists employed significantly more patient involvement and empowerment strategies with the SFA compared with the McKenzie approach. The median (interquartile range)/total possible scores were: SFA 19 (18), McKenzie 10 (4.5)/60 for involvement; and SFA 27 (8), McKenzie 11 (10)/64 for empowerment.

Conclusions

Most physiotherapists were able to switch between the two approaches without significant overlap in techniques. Psychosocial questioning and goal-setting were under-utilised by most physiotherapists. Implementing the SFA protocol appeared to be more difficult than the McKenzie approach, possibly because the SFA was less reliant on a structured format. Physiotherapists may have required more training to enable them to deliver the SFA effectively. The IMPART was a reliable measure of physiotherapists’ involvement and empowerment strategies.     

Postexercise rehydration in man: The effects of osmolality and carbohydrate content of ingested drinks

ObjectiveThis study investigated the effect of the osmolality and carbohydrate content of drinks on their rehydration effectiveness after exercise-induced dehydration.MethodsSix healthy male volunteers were dehydrated by 1.9 ± 0.1% of body mass by intermittent cycle ergometer exercise in the heat before ingesting one of three solutions with different carbohydrate contents and osmolalities over a period of 1 h. Thirty minutes after the cessation of exercise, subjects drank a volume that amounted to 150% (130–150, median [range]) of their body mass loss. Drinks contained 25 mmol/L Na⁺ and 0%, 2%, or 10% glucose with osmolalities of (mean ± SD) 79 ± 4, 193 ± 5, and 667 ± 12 mosm/kg, respectively. Blood and urine samples were collected before exercise, after exercise, and 0, 1, 2, 3, 4, and 6 h after the end of the rehydration period.ResultsSignificantly more of the ingested fluid was retained in the 10% trial (46 ± 9%) than in the 0% trial (27 ± 13%), with 40 ± 14% retained in the 2% trial. Subjects remained euhydrated for 1 h longer in the 10% glucose trial than in the 2% glucose trial. In the 2% glucose trial, plasma volume was elevated immediately after and 1 h after rehydration.ConclusionThis study suggests that, following the rehydration protocol used, hypertonic glucose-sodium drinks may be more effective at restoring and maintaining hydration status after sweat loss than more dilute solutions when the sodium concentration is comparable.     

Volumetric changes in the size of odontogenic keratocysts after decompression followed by enucleation,peripheral ostectomy,and Carnoy's solution: A retrospective study

The study aimed to retrospectively analyze the reduction pattern of odontogenic keratocysts (OKCs) after decompression, followed by enucleation (EN), peripheral ostectomy (PO), and Carnoy's solution (CS) to establish the appropriate time for inserting implants, along with assessing the long-term success of conservative treatment with adjunctive therapy. The predictable variables were the reduction pattern and the study's treatment option. The outcome variable was the volumetric changes in the size of bony defects. These changes were determined using a percentage difference and a reduction rate. They were recorded after decompression and one, three, six, twelve, and eighteen months after EN. P-values of .05 were considered significant. The study included 66 patients with 71 OKCs. Males, younger ages, and mandibular OKCs significantly predominated. The decompression significantly changed the initial volume from 135.40 ± 1.2 cm³ to 101.55 ± 0.1 cm³ with 28.6 percentage difference and 25% reduction rate. At the end of the first and third months after EN, the reduction pattern is 50.0%–75.5% of the initial volume, with no significant prediction for the direction of the reduction pattern. After 18 months, all bony defects disappeared, with no recurrences for the next 18 years. In conclusion, the reduction pattern is 75.5% of its initial volume at the end of the third month after OKC management. Therefore, within the limitations of the study, its treatment approach seems to be an option amongst other protocols that includes a view to early implant based dental rehabilitation.     

康复新液联合生长抑素治疗急性十二指肠溃疡出血的临床研究

目的 探析康复新液联合注射用生长抑素治疗急性十二指肠溃疡出血的临床效果。方法 选取2020年1月—2022年1月中国人民解放军南部战区总医院诊治的106例急性十二指肠溃疡出血患者，以随机数字表法将所有患者分为对照组和治疗组，各53例。对照组首先缓慢静脉注射0.25 mg注射用生长抑素作为负荷剂量，而后立即静脉点滴0.25 mg/h。如果两次输液给药间隔大于3～5 min，采取重新静脉注射0.25 mg注射用生长抑素以确保给药的连续性。治疗组在对照组治疗的基础上口服康复新液，10 mL/次，3次/d。两组连续治疗7 d。比较两组的临床疗效、临床指标、血清炎性因子水平。结果 治疗后，治疗组总有效率为98.11%，显著高于对照组的总有效率83.02%（P＜0.05）。治疗后，治疗组大便隐血转阴时间、禁食时间均短于对照组（P＜0.05）。治疗后，两组血清白细胞介素-6（IL-6）水平均较治疗前下降（P＜0.05）；且治疗组的血清IL-6水平均低于对照组（P＜0.05）。结论 康复新液联合注射用生长抑素治疗急性十二指肠溃疡出血的效果更显著，可有效改善临床症状、降低血清IL-6水平。     

龙脑清洁液促进烫伤大鼠创面愈合的病理学观察

目的 对龙脑清洁液治疗SD大鼠皮肤烫伤创面进行形态学和组织学观察,并探讨其机理.方法 雄性SD大鼠,每只背部制作3个深Ⅱ度烫伤创面,直径1 cm,分别为空白对照点、阳性药物百克瑞消毒喷剂治疗点和龙脑清洁液治疗点,观察3种处理后大鼠烫伤创面的形态学组织学改变,并初步探讨机制.结果 阳性药物百克瑞消毒喷剂治疗点比空白对照点结痂早,创面面积缩小快,脱痂早,光镜观察病理组织切片,阳性药物治疗点较空白对照点各组织损伤较小、再生较好；龙脑清洁液治疗点的结痂时间,创面缩小及脱痂早于阳性药物点,病理学观察皮肤的损伤及再生较阳性药物治疗点好.结论 龙脑清洁液能促进大鼠烫伤创面的愈合.