Differences in effects of Zuojin Pills (左金丸) and its similar formulas on Wei cold model in rats

Objective:To explore the effects of Zuojin Pills(左金丸)and its similar formulas on the stomach cold syndrome in a Wei cold model in rats.Methods:The rat Wei cold model was established by intragastric administration of glacial NaOH,and the gastric mucosa injury indices,together with the levels of motilin and gastrin in the stomach,were determined.The preventive and curative effects of Zuojin Pills and its similar formulas on gastric mucosa injury were investigated.Results:Zuojin Pills and its similar formul...     

安脑丸治疗颅脑损伤合并中枢性高热21例

目的:观察安脑丸治疗颅脑损伤合并中枢性高热的临床疗效。方法:选取2013年1月—2014年5月在本院接受治疗的颅脑损伤合并中枢性高热症患者42例,随机分为治疗组和对照组,每组21例。两组患者均给予西医常规治疗,治疗组在常规治疗的基础上加用安脑丸治疗,将2丸溶于50 m L质量分数0.9%生理盐水中,对于呕吐、意识模糊、吞咽功能异常等不能口服的患者采用鼻饲或者保留灌肠给药,对于意识清晰、吞咽功能正常的患者经口服给药,每日2次,5 d为1个疗程。结果:治疗组治疗后TNF-α、IL-6、CRP水平优于对照组(P0.05);对照组有效率为76.19%,治疗组有效率为90.48%,治疗组优于对照组(P0.05)。结论:安脑丸治疗颅脑损伤合并中枢性高热症临床疗效显著,其作用机制与降低炎症因子TNF-α、IL-6、CRP有关。     

中药配合手法复位小夹板外固定治疗桡骨远端骨折疗效观察

目的:探讨中药配合手法复位小夹板外固定治疗桡骨远端骨折的临床疗效。方法:选取2017年4月—2018年3月桡骨远端骨折患者112例,随机分为2组,各56例。对照组采取手法复位小夹板外固定治疗,观察组采取温阳健骨汤+手法复位小夹板外固定治疗,对比2组临床疗效、疼痛程度、疼痛缓解时间、消肿时间及骨折愈合时间。结果:对照组治疗有效率较观察组低,差异有统计学意义;治疗1周、2周及4周后,观察组VAS评分均较对照组低,差异有统计学意义;与对照组相比,观察组疼痛缓解时间、消肿时间及骨折愈合时间更短,差异有统计学意义。结论:桡骨远端骨折患者采用中药配合手法复位小夹板外固定治疗可有效提升临床疗效,减轻患者疼痛,促进骨折愈合。     

麝香通心滴丸治疗高龄冠心病并肺部感染患者的疗效及对IL-6、PCT水平的影响

目的 探讨麝香通心滴丸治疗高龄冠心病并肺部感染患者的疗效及对白细胞介素-6(IL-6)、降钙素原(PCT)水平的影响.方法 前瞻性选取2018年9月至2020年8月秦皇岛市第二医院收治的120例冠心病并肺部感染患者,随机数字表法分成常规组与研究组,各60例.常规组给予基础治疗,研究组在基础治疗上加麝香通心滴丸治疗.观察...     

止咳丸的药理及毒理研究

对中药止咳丸进行了药理学、毒理学实验研究。结果表明:止咳丸对小鼠化学刺激引起的咳嗽有明显抑制作用;能增强呼吸道分泌功能,起排痰祛痰作用;小鼠经口服给药最大耐受量相当于60g/kg·d;大鼠经4周口服给药的长毒试验未见有明显毒性反应。     

Effect of Wuzi Yanzong Pills on Sertoli cells and blood–testis barrier in heat-stressed rats based on Akt signalling pathway

The blood–testis barrier (BTB) of Sertoli cells (SCs) is an important biological barrier that maintains spermatogenesis and provides a favourable microenvironment for spermatogenesis. However, heat stress can directly damage the BTB structural proteins of testicular SCs, leading to dyszoospermia. Wuzi Yanzong Pills (WYP) is a traditional Chinese medicine formula used to treat male reproductive diseases. However, whether WYP could ameliorate heat stress injury in primary SCs extracted from rat testes and BTB proteins remains unknown. Here, treatment with WYP (low, medium and high dose) increased the SC viability and the proliferation of cell antigen Ki67 significantly. Additionally, it promoted SC maturation, which presented in the form of increased androgen receptors (ARs) and decreased cytokeratin 18 (CK-18) in three WYP dose groups. WYP upregulated BTB proteins such as zonula occludens 1 (ZO-1) and occludin across all WYP groups and decreased phosphorylated Akt (p-Akt) in the middle and high-dose groups; however, ZO-1 and occludin recovery were reduced with the presence of Akt inhibitor in WYP groups. WYP improved SC viability and proliferation, and ameliorated dedifferentiation and BTB-proteins damaged by heat stress via Akt signalling. The findings present theoretical support for the effects of WYP in the management of dyszoospermia and male infertility.     

养血止痛丸联合双醋瑞因治疗膝骨性关节炎20例

目的:观察养血止痛丸联合双醋瑞因治疗膝骨性关节炎(Osteoarthritis of the knee,KOA)的临床疗效。方法:将60例KOA患者随机分为对照组A、对照组B和治疗组,每组各20例。对照组A口服双醋瑞因,对照组B口服养血止痛丸,治疗组口服养血止痛丸和双醋瑞因。观察三组患者的临床疗效及治疗前后KOOS量表积分变化情况。结果:三组患者治疗后KOOS总分及各部分积分显著低于治疗前,且治疗组低于其他两组,差异有统计学意义(P0.05)。治疗组有效率为90.0%,对照组B有效率为85.0%,对照组A有效率为75.04%,三组患者临床疗效比较,差异无统计学意义(P0.05)。结论:养血止痛丸和双醋瑞因治疗KOA均能取得满意疗效,但二者联合运用可显著改善膝关节总体KOOS评分、日常生活活动、娱乐及运动功能、与膝关节相关的生活质量积分。     

当归补血滴丸的制备工艺的研究

目的:优化当归补血滴丸的制备工艺.方法:采用正交试验法确定了药材的提取工艺,通过对基质、浸膏密度等试验,确定了制剂的成型工艺.结果:确定了药材的提取工艺为8倍量水,6倍量60%乙醇,各提取1小时,制剂的成型工艺为基质为原料(总固体)2倍以上、冷却剂的温度10~15℃、浸膏的密度为1.25以上(70℃)、原料温度80~9...     

HPLC法测定桃仁膝康丸中芍药苷的含量

目的建立桃仁膝康丸中芍药苷的含量测定方法。方法采用HPLC法测定芍药苷的含量。色谱柱Agilent C18柱(4.6mm×250mm,5μm),流动相:乙腈-水(13∶87),流速1.0 mL/min,柱温30℃,检测波长230nm。结果芍药苷进样量在0.6128～3.0640μg范围内呈良好的线性关系(r=0.9999),平均加样回收率为99.28%,RSD=1.59%。结论本法操作简便,重现性好,可用于桃仁膝康丸的质量控制。     

金嗓散结丸治疗声带白斑67例临床疗效观察

目的 探讨金嗓散结丸治疗声带白斑的临床疗效.方法 选择2001年3月～2009年10月我院耳鼻喉科门诊经动态喉镜检查证实为声带白斑的病人97例,病史1～6个月不等,治疗组67例,采用中成药金嗓散结丸治疗,9g·次-1,tid,疗程4～8 w;对照组30例,使用金果饮,20 mL·次-1,tid,疗程与治疗组相同,两组均予以地塞米松5 mg及庆大霉素8万U喉超声雾化吸入.结果 治疗组,有效56例,占83.58％,其中治愈39例,占58.21％;对照组,有效6例,占20.00％,其中治愈1例,占3.33％.结论 金嗓散结丸对早期声带白斑疗效确切、疗法安全简便、费用低廉,值得推广.