A multicentric study to evaluate the treatment outcome and complications after oral rehabilitation with implant-supported hybrid prostheses

BackgroundAs a newer modality of rehabilitation of completely edentulous patients, there is no conclusive evidence on which of the variants of hybrid prosthesis, namely acrylic teeth on a metal substructure or porcelain fused to metal teeth over on a metal substructure, is better in terms of treatment outcome, reduced mechanical complications, and better patient compliance.MethodsSixteen completely edentulous patients, both male and female, were selected from the OPD of the study centers during the study period. Group A: Eight patients rehabilitated by maxillary and mandibular hybrid prosthesis using a substructure of metal covered by acrylic teeth, which was screwed on the implants. Group B: Eight patients rehabilitated by maxillary and mandibular hybrid prosthesis using a substructure of metal covered by porcelain fused to metal teeth, which was screwed on implants. The patients were recalled at 3 months, 6 months, and 1 year following rehabilitation, and necessary clinical and radiological observations were made to evaluate the overall health and complications. Oral health–related quality of life was measured using the Oral Health Impact Profile (OHIP)-EDENT questionnaire before treatment and after rehabilitation. The same methodology, clinical procedures, and evaluation criteria were followed in all the study centers. The data obtained were then compiled and analyzed.ResultsNone of the patients in group A or B showed any signs of need to remake. There was no statistically significant difference in proportions of cases showing signs of loosening of components, soft tissue overgrowth, breakage of acrylic, chipping of porcelain, and wear of teeth in both the groups. The amount of screw loosening, wear of prosthetic superstructure, and bone loss around implants were less (even though not statistically significant) in group A. Both the groups showed satisfactory esthetics. OHIP- EDENT evaluation gave completely satisfactory report after rehabilitation in both groups.ConclusionBoth the types of complete rehabilitation, hybrid prosthesis of acrylic teeth on a metal substructure and hybrid prosthesis of porcelain fused to metal teeth on a metal substructure were successful and comparably reliable.     

癌症患者复发恐惧的潜在剖面分析

目的 探讨癌症患者复发恐惧的潜在类别特征，并分析不同类别癌症患者的特征差异。方法 采用按比例分配连续性抽样的方法，选取2021年2月—10月在沈阳市某三级甲等医院住院治疗的肺癌、胃肠道癌、乳腺癌及妇科肿瘤的癌症患者作为调查对象。采用一般资料调查表、疾病不确定感量表、医院焦虑抑郁量表、领悟社会支持量表及癌症复发恐惧量表简版进行调查。结果 最终共调查390例癌症患者，其中76.7%存在癌症复发恐惧；癌症复发恐惧表现为3种不同潜在类别，分别命名为“低复发恐惧-外向型”“中复发恐惧-常规型”和“高复发恐惧-神经质型”，占比依次为19.5%、59.7%、20.8%。相较于“低复发恐惧-外向型”，焦虑水平越高的癌症患者归属于“中复发恐惧-常规型”和“高复发恐惧-神经质型”的概率越大（OR=1.282,P=0.016;OR=1.378,P=0.010）；而社会支持水平越低的癌症患者归属于“中复发恐惧-常规型”和“高复发恐惧-神经质型”的概率越大（OR=0.948,P=0.010;OR=0.900,P<0.001）；疾病不确定感水平越高的癌症患者归属于“高复发恐惧-神经质型”的概率越大（OR=1...     

护士组织沉默现状及潜在剖面分析

目的 探讨护士组织沉默的现状，并分析其潜在剖面及人群特征。方法 采用便利抽样法，于2020年6月选取中国东北、华南、华中、华北、华东、西南、西北七大地区二级及以上医院的护士作为调查对象。采用一般资料调查表、员工沉默行为调查量表和同事支持量表进行问卷调查。对护士组织沉默特征进行潜在剖面分析，并通过单因素分析和Logistic回归分析识别其潜在剖面的影响因素。结果 最终共纳入3 974名护士，其组织沉默分为4个潜在剖面，分别为“局外人”（15.60%）、“顺从者”（22.60%）、“中间人”（37.75%）和“主人公”（24.06%）。Logistic回归分析结果显示，护士的家庭经济负担、健康状况、职务、护士长支持得分、同事支持得分和医院等级是组织沉默潜在剖面类别的影响因素（P<0.05）。结论护士组织沉默特征存在异质性，可分为4个潜在剖面。护理管理者可根据不同潜在剖面的影响因素对护士进行个体化干预，以降低护士组织沉默水平。     

Pain,Anxiety, and Quality of Life of COVID-19 Survivors with Myofascial Pain Syndrome: A cross sectional study

BackgroundPeople who have survived COVID-19 may develop chronic pain.AimsTo investigate the difference in pain level, anxiety, functional status, and quality of life in COVID-19 survivors with myofascial pain syndrome (MPS) in the trapezius muscle compared with MPS patients without COVID-19.DesignCross-sectional observational study.SettingsPhysical medicine and rehabilitation outpatient clinics of a single tertiary-care hospital.Participants/SubjectsEighty patients (40 patients with MPS and 40 patients with MPS + COVID) who were diagnosed with chronic MPS in the trapezius muscle were evaluated.MethodsPain level of the patients was evaluated using the visual analogue scale (VAS), the functional status with the Neck Pain and Disability scale, the psychosocial effects of the pain with the Beck Anxiety Inventory, and the quality of life with the Nottingham Health Profile tests, and the two groups (MPS and MPS + COVID) were compared.ResultsA significant difference was observed between the groups in terms of pain, anxiety, and disability (p < .001). MPS + COVID group showed significantly greater pain intensity on VAS and higher mean total scores on Nottingham Health Profile, Beck Anxiety Inventory, all Nottingham Health Profile subdomains (pain, emotional reactions, sleep, social isolation, physical mobility, energy) compared with the MPS group (p < .001).ConclusionsAfter recovering from COVID-19, patients with MPS showed increased pain, anxiety, disability, and decreased quality of life.     

当归对自发性高血压大鼠脑组织Tnfaip8l2、Ahsg及Tlr3基因表达的影响

目的 探讨当归对自发性高血压（SHR）大鼠脑组织肿瘤坏死因子α诱导蛋白8样蛋白（Tnfaip8l2）、 α₂-HS糖蛋白（Ahsg）及Toll样受体3（Tlr3）基因表达谱的影响。方法 将SHR大鼠分为当归组、模型组，并将同周龄的Wistar大鼠作为对照组。测定用药前后各组尾动脉收缩压；分组灌胃给药4周后，取大鼠脑组织，提取RNA进行表达谱的测定。结果 当归可降低SHR大鼠的血压水平；同时基因表达谱分析显示当归可导致Tnfaip8l2、Ahsg及TLR3基因表达上调，且为差异表达上调基因，而这三个基因均为动脉粥样硬化抑制因子。结论 当归具有一定的降压作用，并对SHR脑组织基因表达谱产生影响，通过抑制动脉粥样硬化的发生发挥作用。