The present investigation is concerned with the possible effects of material-related properties (molecular mass, glass transition and melting temperatures, crystallinity, tacticity) and particle-related properties (shape, size, specific surface area) on the compression characteristics of the chosen model polymer powder: poly(vinyl chloride) (PVC). Four grades were selected known in literature for providing compacts of varied mechanical strength. The compression characteristics were determined using an instrumented single-punch tableting machine. The differences in tableting characteristics could not be ascribed to any of the material-related properties, but a direct relationship was observed between the compact strength and the specific surface area of the particles, as measured by nitrogen adsorption. The compact hardness was thus only dependent on the inter- and the intraparticulate contact area, which in turn is dictated by the very peculiar morphology of the grains of the PVC powders, whether prepared by emulsion or suspension polymerization. 相似文献
Performance degradation in membranes for polymer electrolyte fuel cells was discussed theoretically for the case where the membrane is contaminated with foreign impurity cations at the cathode side. Water transport in a two-cation system membrane was considered by assuming an ‘infected zone’ of finite thickness. Four kinds of boundary value problems were solved, and analytical formulae derived for the water concentration profile across the membrane. The water content in the membrane, the net water flux and the membrane resistance overvoltage were calculated systematically as functions of several relevant parameters in fuel cell operations. Localized contamination at the cathode ∣ membrane interface turned out to be even more serious than the uniform contamination of the membrane or localized contamination at the anode side. It is noted that special caution should be directed in order to avoid the membrane contamination, especially at the cathode side, because contaminant will easily enter from the air stream through the cathode compartment of a fuel cell. 相似文献
Incorporation of the antitubercular drug isoniazid, INH, into low density poly(
-lactide-co-glycolide), PLGA, foams of high interstitial void volume prior to high pressure extrusion is shown to prolong the in vitro release of INH. In vitro studies indicate that the duration of INH release can be significantly increased, the early burst dramatically reduced, and variation in replicate samples reduced. Control of the specific gravity and interstitial void volume of the foam is achieved by lyophilization of frozen polymer solutions of specified concentration. The morphology of foams prepared by lyophilization of glacial acetic acid solutions of the polymers produces leaflet or platelet structures. Matrices were prepared by (1) extruding INH impregnated foams previously compacted and ground to 125–180 microns, (2) directly extruding impregnated foams without prior compaction and grinding, and (3) extruding mechanically mixed micronized INH and ground PLGA which had not been prepared as foam. INH release kinetics, analyzed in terms of the Roseman-Higuchi model, confirms that release is diffusion controlled. Diffusion constants for the three methods are 1.2( ±0.1) × 10−4, 2.1(±0.3) × 10−4, and 3.2(± 1.6) × 10−4 cm2/day. 相似文献
Recent studies suggest that neurotrophic factors applied directly to brain tissue may enhance regeneration in the central nervous system. Biocompatible polymeric implants providing a controlled release of nerve growth factor (NGF) for over one month were developed. The released nerve growth factor stimulated neurite sprouting in cultured PC12 cells. While a model polymer with demonstrated biocompatibility was used for the present study, the methods can be extended to other polymer systems. Controlled release implants may be useful in the treatment of Alzheimer's disease. 相似文献
Crystalline/amorphous binary mixtures of polystyrene with different tacticities, syndiotactic/atactic isomers (sPS/aPS), have been systematically studied to reveal the composition dependence of the blend morphologies, i.e., sPS lamellar structure and aPS diluent segregation, developed after isothermal crystallization. To reveal the molecular weight effect of the aPS diluents, four different of aPS were used to prepare blends with various compositions. After being melt crystallized isothermally at 250 °C, all blends were investigated by means of POM, WAXS, and SAXS as well as SEM and TEM to reveal the spherulitic and lamellar morphologies developed.
The self‐assembly and structure formation in binary blends of asymmetric polystyrene‐block‐poly(4‐vinylpyridine) diblock copolymers in different solvent systems and the bulk morphology of the blend films are studied by using dynamic light scattering, small‐angle X‐ray scattering, and transmission electron microscopy. In dilute solutions, the chains of pure diblock copolymers or binary blends of diblock copolymers having similar or different molecular weights remain as unimers, form common micelles in selective solvents or form unimers in coexistence with micelles in slightly selective solvents or solvent mixtures. The blends show mixing of the chemically similar blocks in the blend films and solutions at high concentrations. A single‐phase with common spherical morphology is formed in the blend films similar with the morphology of the individual components in the pure state. The characteristic length scale of the blends depends on the number average molecular weight following the typical scaling behavior of a strongly segregated block copolymer.