Efectividad y seguridad de 2 dispositivos de fototerapia para el manejo humanizado de la ictericia

IntroductionNeonatal jaundice is common, especially in premature infants. Compliance with treatment protocols and standard serum bilirubin curves forces the clinician to separate the child from the mother after birth for short phototherapy. The objective of this study is to evaluate the effectiveness and safety of two innovative devices for phototherapy including a LED light mesh: one sleeping bag and one blanket compared to conventional hospital or ambulatory phototherapy.MethodsTwo randomised clinical trials were conducted: one with newborns > 2,000 g at birth in the Neonatal Care Unit and the other with premature infants followed-up in an outpatient clinic (PMC). The gold standard for bilirubin measurement was serum bilirubin, and ambulatory controls were performed with the Bilicheck®. Parents and health personnel completed a questionnaire on comfort and perceptions.ResultsIn the study using the bag, a linear regression was performed for the decrease in bilirubin in mg/dL/h, controlling by early jaundice (< 36 h) and the device type. The results were similar between the 2 devices. For the blanket trial in the PMC, the decrease in bilirubin levels with the new device was significantly greater with no differences in temperatures, duration of phototherapy, re-admission, mortality, or side effects for both trials. Parents and staff satisfaction with the two devices was identical for the 2 trials.ConclusionThese 2 small studies add a ‘grain of sand’ to humanisation of newborn care, avoiding the mother-and-child separation for both the intra-hospital high-risk hyperbilirubinaemia, as well as for the lower-risk hyperbilirubinaemia in an outpatient clinic.     

Clinical and scientific recommendations for the use of photobiomodulation therapy in exercise performance enhancement and post-exercise recovery: current evidence and future directions

Background

There is about ten years since the first randomized controlled trial looking for the effects of photobiomodulation therapy using low-level laser therapy and/or light emitting diodes therapy in athletic performance enhancement was published. Since then, the knowledge in this field has increasing exponentially.

强脉冲光治疗增生期浅表草莓状血管瘤疗效观察

目的 观察强脉冲光（intense pulsed light,IPL）治疗婴幼儿增生期浅表草莓状血管瘤的治疗效果.方法 采用Queen IPL系统,选择合适的能量及间隔时间治疗68例婴幼儿增生期浅表草莓状血管瘤,并进行疗效评定.结果 总有效率为76.47%,少数患儿在治疗过程中出现水泡、色素沉着等不良反应.结论 IPL可以作为婴幼儿增生期浅表草莓状血管瘤的前期治疗方案.     

新生儿黄疸系统护理措施效果研究

目的探讨有效的新生儿黄疸系统性临床护理措施。方法112例新生儿黄疸患儿被随机分为系统护理组和对照组,系统护理组实施水疗、抚触和光疗,对照组实施常规护理措施,比较两组新生儿排便情况和血清胆红素水平变化。结果系统护理组的新生儿在干预前2天排便次数明显多于对照组,干预后血清总胆红素水平显著低于对照组（P〈0．05）。结论系统护理能有效帮助新生儿快速降低体内胆红素水平,防止并发症的发生。     

刺络拔罐联合红蓝光治疗女性迟发性痤疮临床观察

目的：探讨女性迟发性痤疮的有效治疗方法及机理。方法：将60例患者随机分为治疗组40例,对照组20例。治疗组采用刺络拔罐联合红蓝光治疗,对照组采用口服丹参酮胶囊和外用玫芦消痤膏治疗,观察疗程为8周。评价其临床疗效并观察2组患者治疗前后外周血中睾酮（T）、雌二醇（E2）。结果：临床疗效总有效率治疗组为92．5％,对照组为90．0％,2组比较,差异无显著性意义（P〉0．05）。治疗后治疗组血清T水平下降,差异有非常显著性意义（P〈0．01）,E：水平上升,差异无显著性意义（P〉0．05）;对照组血清T、岛水平变化不明显,治疗前后比较,差异均无显著性意义（P〉0．05）。结论：刺络拔罐联合红蓝光治疗女性迟发性痤疮具有明显的临床疗效,其可能通过调节机体性激素水平达到治疗目的。     

光疗对新生儿血清钙影响

目的探讨蓝光治疗新生儿高胆红素血症对血清钙的影响。方法将90例新生儿高胆红素血症患儿按胎龄分为足月儿及早产儿两组,足月儿50例,早产儿40例,测定光疗前后血清钙水平,比较两组低钙血症的发生率。结果足月儿和早产儿光疗后血清总钙和游离钙均下降（P〈0.01）,早产儿低钙血症的发生率为50.0%,足月儿为28.0%,两组比较有显著性差异（P〈0.05）。结论新生儿接受光疗时易发生低钙血症,其中早产儿比足月儿发生率更高,光疗时应监测血钙浓度,必要时补钙。     

Phototherapy promotes cell migration in the presence of hydroxyurea

Phototherapy has been shown to cause an increase in cell proliferation and migration. This study focused on viability (trypan blue), proliferation [sodium 3′-(1-(phenylaminocarbonyl)-3,4-tetrazolium)-bis(4-methoxy-6-nitro)-benzene sulphonic acid hydrate (XTT) and adenosine triphosphate (ATP)] and migration of WS1 cells following irradiation in the presence of hydroxyurea (HU), which is an inhibitor of proliferation. Wounded cells were irradiated on days 1 and 4 with a fluence of 5 J/cm² with a helium–neon (He-Ne) laser at 632.8 nm. After a repair time of 24 h, cellular responses were assessed. Wounded irradiated cells without HU showed an increase in cell viability and proliferation, which was confirmed by complete wound closure by day 4. Although wounded irradiated cells treated with 5 mM HU showed incomplete wound closure, these cells showed increased migration compared with that of control cells. This study showed that laser irradiation using an He-Ne laser with a fluence of 5 J/cm² stimulates cell viability. The HU results confirmed that laser irradiation promotes cell migration and proliferation.     

Classics in brachytherapy: Margaret Cleaves introduces gynecologic brachytherapy

Intracavitary treatment of gynecologic cancers has been the anchor of brachytherapy, and perhaps the greatest success of radiotherapy, for over a century. The woman who first performed the procedure was neither a surgeon nor radiologist, but an electrotherapeutist who began her career as an alienist. She pursued a prolific academic career despite being disabled by a disease that is no longer recognized. The fascinating life of Margaret Cleaves, the initiator of gynecologic brachytherapy, is recounted.