Effect of resveratrol on peritoneal macrophages in rats with severe acute pancreatitis

Objective: The literature on resveratrol in severe acute pancreatitis (SAP) is limited though it has been widely studied in infections and trauma. The aim of this study was to investigate the inhibitory effect of resveratrol on inflammatory responses in a rat model of SAP. Methods: Male Sprague-Dawley (SD) rats were randomly divided into 3 groups: SAP group, resveratrol group and control group. 4.0% sodium taurocholate was injected into the pancreatic duct to induce SAP. In the resveratrol group, resveratrol (10 mg/kg) was injected through penal vein 5 min after SAP was induced. The peritoneal macrophages of the rats were collected 3, 6 and 12 h after stimulus and then incubated for 24 h. The expression of nuclear factor kappa B (NF-κB) and inducible nitric oxide synthase (iNOS) in peritoneal macrophages was measured. The levels of tumor necrosis factor alpha (TNF-α), interleukin-1 (IL-1) and nitric oxide (NO) in culture medium of peritoneal macrophages and serum of rats were evaluated. Results: Histological examination of pancreas indicated that the damage in the SAP group was more severe than that in the resveratrol group. The expression of NF-κB and iNOS in peritoneal macrophages was significantly higher in the SAP group than in the resveratrol group. The concentrations of TNF-α, IL-1 and NO in culture medium and serum were significantly elevated in the SAP group when compared with the resveratrol group. Conclusions: The inhibiting effect on the inflammatory response and the decreased expression of TNF-α, IL-1 and NO in peritoneal macrophages suggest resveratrol as a novel anti-inflammatory agent for reducing the severity of SAP. Received 5 July 2005; returned for revision 18 September 2005; accepted by K. Visvanathan 22 September 2005     

大黄和早期肠内营养对重症胰腺炎病程的影响

目的：探讨大黄和早期肠内营养（EN）对重症胰腺炎（SP）病程的影响。方法：对重症胰腺炎保守治疗者在入院后即刻,急诊手术者术后24h经鼻空肠管或空肠造瘘管内注入大黄,蓖麻油,蕃泻叶,并对肠功能恢复者早期实施肠内营养。结果：患者在实施上述方案后,腹胀缓解,全身中毒症状减轻,胰腺感染率,并发症,死亡率下降,住院天数和住院费用减少。结论：大黄和早期肠内营养对重症胰腺炎早期减少菌群移位,晚期减少胰腺感染和提高治愈率等方面有重要意义。     

重症急性胰腺炎的手术时机与预后

目的：探讨重症急性胰腺炎的手术时机与预后。方法：对我院72例重症急性胰腺炎的治疗,按不同时期,进行回顾性统计、分析。结果：早期手术组,延期手术组和非手术组并发症分别为56％,27％,20％。死亡率分别为20％,0％,4％。早期手术组并发症和死亡率明显较高于后二组。结论：重症胰腺炎的治疗选择直接影响预后,早期积极的手术治疗不能降低并发症和死亡率,除胆源性胰腺炎外,早期手术指征应从严掌握。     

急性重症胰腺炎肠源性感染的发病机制及防治

腹腔感染是急性重症胰遥炎死亡的主要原因。目前认为感染来源于肠粘膜屏障受损所导致的细菌移位,但肠粘膜屏障受损的机制尚不清楚。本文综合了肠粘膜间受损的可能原因,重点讨论了重症胰腺炎时细胞因子对肠粘膜屏障的影响和肠粘膜屏障的变化。同时针对感染发病原因提出了相应的治疗对策。     

胆源性胰腺炎血清急性时相性蛋白水平的研究

目的：探讨血清急性时相性蛋白在胆源性胰腺炎时的改变及其对病情评估的作用。方法：３０例患者,分别为一般胆石症组１０例,轻型胆源性胰腺炎１０例,重型胆源性胰腺炎１０例。测定各病例入院第１、４、７、１４ｄ的Ｃ－反应蛋白（ＣＲＰ）和前清蛋白（ＰＡ）。结果：ＣＲＰ在重型组４次测定均明显高于另两组（Ｐ〈０．０１）,第４、７、１４ｄ轻型组亦高于一般组（Ｐ〈０．０５）。ＰＡ在重型组亦均明显高于另两组（Ｐ〈０．０５     

Malignant islet cell tumor projecting into the main pancreatic duct

We report herein a rare case of islet cell tumor showing a unique growth pattern in a patient who developed repeated acute pancreatitis as the tumor's initial symptom. Preoperative imaging examinations showed dilatation of the main pancreatic duct (MPD) and cysts around the pancreatic tail. A distal pancreatectomy with splenectomy was performed because the pancreatitis was localized in the distal pancreas and was not controlled by various drug therapies. Grossly, the tumor consisted of two component parts: a markedly infiltrative part in the pancreatic parenchyma, and a papillary elevated part in the MPD. The MPD was obstructed by the tumor spreading widely along the distal MPD. Microscopically, the tumor was composed entirely of islet cell tumors (nonfunctioning), with several foci of venous and lymphatic involvement. Based on its growth behavior, we assumed that the tumor may have arisen from the MPD or from islet cells closely adjacent to the MPD. The patient's postoperative course was uneventful and he is doing well 2 years after the operation. We discuss the growth pattern of the tumor and the cause of the pancreatitis. Received: March 30, 2000 / Accepted: July 12, 2000     

急性重症胰腺炎临床治疗

目的：探讨并论述重症急性胰腺炎的临床治疗。方法：阅读关于重症急性胰腺炎临床治疗方面的文献,进行总结。结果：非感染性重症急性胰腺炎以内科治疗为主,感染性重症胰腺炎宜外科手术介入治疗为主。结论：重症急性胰腺炎死亡率高,早期诊断治疗十分重要。早期主要是积极的药物治疗。包括抗生素的使用以防止感染。而外科手术及其他的介入治疗一般只限于感染性坏死的患者。     

多层螺旋CT与MRI扫描对胰腺癌、慢性胰腺炎的诊断价值研究

目的 通过使用多层螺旋CT与MRI扫描对胰腺癌、慢性胰腺炎进行诊断,探讨其诊断价值.方法 选取本院2017年4月至2019年7月收治的56例慢性胰腺炎及28例胰腺癌患者的临床资料,观察两种疾病的影像学检查表现,对比MSCT、MRI检查下两种疾病的诊断准确率.结果 胰腺癌病变主要表现为胰腺体积增大、向周围组织及大血管侵犯...     

糖皮质激素在暴发性胰腺炎治疗中的应用研究

目的 :探讨糖皮质激素治疗暴发性胰腺炎 (FAP)的效果。方法 :对 3 6例FAP病人进行回顾性分析 ,将未使用糖皮质激素组与使用糖皮质激素组治疗效果进行比较。结果 :研究组与对照组的SOFA最高评分、肺、心功能衰竭的发生率及病死率分别为 ( 8.12± 3 .69)分和 ( 10 .68± 3 .3 3 )分 ;41.18%和 78.95 % ;41.18%和 73 .68% ;11.77%和47.3 7% (P <0 .0 5 )。结论 :及早、足量使用糖皮质激素治疗FAP效果良好