Improvement of morphological changes after 70% hepatectomy with portocaval shunt: preclinical study in porcine model

BACKGROUND: After extensive hepatectomy, excessive portal venous flow (PVF) and elevated portal venous pressure (PVP) may lead to postoperative liver damage. We have evaluated the use of portocaval shunt (PCS) to control PVF and PVP following partial hepatectomy (PH) to reduce the postoperative liver damage. METHOD: Twenty-four pigs were divided into two Groups: Group C (n = 10) underwent 70% PH alone and Group S (n = 14) underwent 70% PH with PCS. The changes in PVF, PVP, serum liver function tests, and histology were evaluated. RESULTS: PVP and PVF per unit of remnant liver weight and serum total bilirubin levels in Group S were significantly lower than those in Group C postoperatively (P < 0.05). Histology showed that there were significant differences in hepatocyte ballooning, necrosis, and neutrophil aggregation between the two groups (P < 0.05). In particular, hepatic necrosis was observed in zone 3 of Group C as centrilobular necrosis. These results suggest that hepatic and sinusoidal damage after 70% PH were more severe in Group C than in Group S, with the latter group maintaining an almost normal ultrastructural appearance. Hepatocyte apoptotic index differed significantly between the two groups (P < 0.0001). CONCLUSION: After 70% PH, extensive centrolobular necrosis and neutrophil aggregation were present and may have caused liver damage, manifested as hyperbilirubinemia and coagulopathy. The delayed liver regeneration with PCS may reduce the postoperative liver damages rather than the rapid liver hypertrophy. The diversion of PVF with PCS to maintain adequate PVP is a very effective procedure for avoiding the postoperative liver failure after extensive hepatectomy.     

银夹及PVF医用海绵联合应用于鼻内镜下泪囊鼻腔造孔术

目的探讨鼻内镜下泪囊鼻腔造孔术的改良方法。方法将181例慢性泪囊炎并行鼻内镜手术治疗的患者随机分成3组。银夹+PVF组(60例):术中用银夹将泪囊黏膜瓣固定于钩突前缘鼻腔黏膜瓣,并以PVF医用海绵支撑泪囊腔。PVF组(62例):术中以PVF医用海绵支撑泪囊腔。银夹组(59例):术中用银夹将泪囊黏膜瓣固定于钩突前缘鼻腔黏膜瓣。结果①术后3个月随访,3组治愈率分别为93.94%、82.09%和79.69%。②术后3个月3组患者满意度分别为(82.26±11.00)分、(76.76±10.565)分和(73.78±9.991)分。结论银夹及PVF医用海绵联合应用,能有效显著提高鼻内镜下泪囊鼻腔造孔术成功率。