盐酸二甲双胍治疗奥氮平导致的精神分裂症患者代谢综合征的疗效及其与慢性炎症状态的关系

目的：分析二甲双胍治疗奥氮平导致的精神分裂症患者代谢综合征（MS）的疗效,并进一步分析治疗过程中C-反应蛋白（CRP）和肿瘤坏死因子-α(TNF-α)的变化。方法：按照入组病历号随机选取满足入组标准和排除标准的精神分裂症患者100例,依据随机数字表分为研究组和对照组各50例,干预治疗前和24周后分别检测患者体质量指数（BMI）、稳态胰岛素评价指数（HOMA-IR）、空腹血浆葡萄糖（FPG）、糖化血红蛋白（Hb A1c）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、总胆固醇（TC）、甘油三酯（TG）、CRP和TNF-α,并进行统计分析。结果：两组患者性别、受教育程度、婚姻、家族史、病程、年龄和奥氮平治疗剂量分布差异无统计学意义（P>0.05）。盐酸二甲双胍治疗后研究组BMI、HOMA-IR、FPG、HbA1c、HDL-C、LDL-C、TC、TG、CRP、TNF-α的差值明显高于对照组（P<0.05）。研究组CPR和TNF-α与BMI和HOMA-IR呈显著正相关,ΔCPR可以分别解释ΔBMI变异的13.4%,ΔHOMA-IR变异的11.4%;ΔTNF-α...     

脑电熵在麻醉深度监测中的意义

随着肌松药和镇痛药等药物的联合应用,现代全身麻醉的深度、患者的意识状态常常被掩盖或难以判断.以往的传统体征(血压、心率、呼吸和瞳孔等)已不能准确地反映麻醉深度.目前,有关研究重点集中在脑电活动方面,如脑电双频指数(bispectral index,BIS)、脑电熵(entropy)、听觉诱发电位等.现就entropy在麻醉深度监测中的意义及其研究进展作一综述,并与脑电双频指数进行比较.     

Brunnstrom运动分期综合治疗脑梗死初探

目的:评估针刺结合推拿和康复治疗脑梗死神经功能、日常生活活动能力。方法:43例均采用西医对症治疗,同时进行针刺、推拿和康复治疗。结果:针刺治疗前、第20、40次针刺治疗后斯堪的纳雏亚卒中量表评分依次升高(P<0．01), Brarthel指数也依次升高(P<0．01)。结论:针刺结合推拿和康复治疗可明显改善脑梗死患者神经功能和日常生活活动能力。     

Temporal effect of Guanxin No. 2 on cardiac function, blood viscosity and angiogenesis in rats after long-term occlusion of the left anterior descending coronary artery

AIM: Cardiac infarction is one of the main causes of death in both developing and developed countries over past decades. Currently available approaches for treating patients with this disease are not satisfactory. Traditional Chinese medicines have been increasingly paid attention to. The aim of this study was to characterize the dynamic protective effects of Guanxin No. 2 decoction (GX II) on cardiac dysfunction combined with the blood viscosity and myocardial hypertrophy parameters in myocardial infarction (MI) rats. METHODS: Male Sprague-Dawley rats (180-200 g) were randomly divided into three groups: sham-operated, coronary artery ligation (CAL), and CAL plus GX II (GX II, 10.0 g raw materials/kg/d, bid, p.o.). The experiment was carried out at 4 time points as the 3rd, 7th, 14th, and 28th day after ligation. RESULT: It was found that on the one hand, GX II could significantly improve the heart function, and remarkably decrease infarct size and inhibit ventricular remodeling. On the other hand, GX II showed some unique effects such as angiogenesis which was induced in the left ventricular tissue. This result was consistent with the finding of an augmented vascular endothelial growth factor (VEGF) expression in this area. CONCLUSIONS: The studies demonstrated that GX II exerted extensively beneficial cardioprotective effect on CAL rats, it might stimulate angiogenesis of ischemic region to compensate blood supply to the heart via upregulated VEGF expression.     

Prepregnancy body mass index and adverse pregnancy outcomes

OBJECTIVE: The aim of this study was to evaluate the association between prepregnancy BMI, and adverse maternal and neonatal outcomes. METHOD: In this retrospective cohort study 916 consecutive singleton gestations were included who gave birth between 1 January 2006 and 31 August 2006 at the Department of Obstetrics and Gynecology, University of Udine, Italy. Statistical analysis was performed using univaried logistic regression and measured by odds ratio. RESULTS: The obese patients had a statistically, significantly increased incidence of Caesarean section (OR = 2.17, p = 0.009). Women with overweight (OR = 2.43, p = 0.002) and obese weight (OR = 4.86, p < 0.0001) were at increased risk for preterm deliveries. The pre-eclampsia and the fetal macrosomia (> or =4,000 g) were increased in obese women (OR = 5.68, p < 0.0001; OR = 2.58, p = 0.033, respectively). CONCLUSION: Maternal prepregnancy obesity is significantly associated with increased risk of Caesarean section, preterm delivery, pre-eclampsia and macrosomia.     

中西医结合治疗对糖尿病患者血管内皮功能的影响

目的:观察中西医结合治疗糖尿病患者的临床疗效,及其对患者血管内皮功能的影响。方法:将58例糖尿病患者采取随机数字法平均分成对照组和治疗组。对照组给予西医常规治疗,治疗组在对照组用药的基础上,给予口服益气养阴通络方治疗。两组均4周为1个疗程,连续治疗3个疗程。观察两组治疗前后临床症状、空腹血糖(fasting blood-glucose,FBG)、糖化血红蛋白、胰岛素、胰岛素抵抗指数、NO、内皮素-1(endothelin-1,ET-1)和血管内皮生长因子(vascular endothelial growth factor,VEGF)的变化。结果:1对照组、治疗组有效率为72.4%和86.2%,两组有效率比较,差异有统计学意义(P<0.05);2治疗后治疗组中医证候积分明显降低(P<0.01),对照组改变不显著,两组间比较,差异有统计学意义(P<0.01);3治疗后两组血FPG、GHB、胰岛素、胰岛素抵抗指数较治疗前明显下降(P<0.01),以治疗组改善更为显著(P<0.05或P<0.01);4治疗后两组NO升高、ET-1、VEGF降低(P<0.01),以治疗组改善更为显著(P<0.05)。结论:中西医结合治疗糖尿病疗效显著,能明显改善患者的临床症状,调节血管内皮功能,对防治糖尿病心血管病变具有一定作用。     

苏拉明对体外培养视网膜色素上皮细胞增殖的影响

目的　研究苏拉明 (suramin)对培养人视网膜色素上皮细胞 (retinal pigm ent epithelium,RPE)增殖的影响 .方法　将不同质量浓度的苏拉明 (1.5 ,15和 15 0 mg· L- 1 )加入RPE细胞培养液 ,采用四甲基偶氮唑盐 (tetrazolium,MTT)比色法 ,细胞分裂指数计数和核仁组成区嗜银染色(Ag NORs)检测苏拉明对 RPE增殖活力的影响 .结果　含有10 0 m L· L- 1小牛血清的培养液可以显著刺激 RPE的增殖(P<0 .0 1) ,无血清组 A值为 0 .19± 0 .0 1、含血清组 A值为0 .30± 0 .0 1;苏拉明抑制了 10 0 m L· L- 1血清条件下 RPE的增殖 ,呈剂量依赖性 ,最大抑制率达 5 1% ,3种浓度组 A值分别为 0 .2 9± 0 .0 1,0 .2 4± 0 .0 1和 0 .14± 0 .0 1,对细胞的形态无明显影响 .结论　苏拉明对血清刺激 RPE增殖有显著非毒性抑制作用