论名医成才与中医高等教育

源于中国五千年文明史的中国医学,实际上是一门不能完全等同于西方医学而具备人文特点的学科。这门学科因为其独特的发展过程,故具有较强的哲学性、实践性和经验性的特点,使其成为独立于自然科学之外的一门科学学科。其基本理念的不同也让西医教育的模式化阻碍了中医教育的发展和提高,应用多学科知识研究发展中医是中医教育的必由之路。     

马艳东治疗慢性咳嗽经验

在慢性咳嗽的发病机制上,马艳东主任提出"痰湿瘀三气杂至合而为浊"的病理新机制,认为慢性咳嗽基本病机为"浊郁肺络",并创立捜络剔浊法。马艳东老师认为慢性咳嗽不论是急性发作期还是缓解期都不能忘记祛除痰浊,要寻找滋生痰涎的因素,辨别痰的性质,采取"因势利导""制源畅流"的方法。久咳时"非宣通肺气则邪气留恋不解,非肃降肺气则气机逆乱不调",用药当宣肃并行,帮助肺脏恢复气机,则外邪得解,痰浊自化,气道通畅,咳嗽自息。马老师紧抓其"浊郁肺络"基本病机,用药以搜络剔浊药为主,并注意宣肃并行、寒温相宜、润燥相兼,巧补肺脾肾,使痰浊得除、外邪得祛,气血调畅,气道通利、标本兼顾。     

藏药湿生扁蕾提取物通过NF-κB通路诱导结肠癌细胞凋亡的机制研究

目的：探讨藏药湿生扁蕾提取物通过 NF －κB 信号通路诱导结肠癌 SW480细胞凋亡的作用及其机制。方法本研究用不同浓度的藏药湿生扁蕾提取物处理结肠癌 SW480细胞,通过 JC －1染色检测 SW480细胞线粒体膜电位的变化,通过 Hoechst 染色以判断藏药湿生扁蕾提取物是否具有诱导结肠癌细胞 SW480细胞凋亡效应。同时检测 NF －κB 蛋白的表达,用以明确 NF －κB 信号通路在结肠癌发生中的作用机制。结果经一定浓度的湿生扁蕾提取物处理后的 SW480细胞内,NF －κB 的表达明显下调,染色现象揭示湿生扁蕾提取物具有促进肿瘤细胞凋亡的作用。结论湿生扁蕾提取物可以在体外诱导肿瘤细胞凋亡,其抗肿瘤机制是通过 NF －κB 信号通路介导的。     

苦参汤熏洗联合马应龙麝香痔疮膏治疗混合痔术后疗效研究

目的:探讨苦参汤熏洗联合马应龙麝香痔疮膏在混合痔(MH)术后的应用效果。方法:按入院顺序将85例MH术后患者分为两组,对照组(n=42)予马应龙麝香痔疮膏治疗,联合组(n=43)予苦参汤熏洗联合马应龙麝香痔疮膏治疗。2周后,比较两组疗效、伤口疼痛及愈合情况,测定创面组织血管内皮生长因子(VEGF)、碱性成纤维生长因子(bFGF)、肛门功能。结果:联合组总有效率95.35% 高于对照组78.57%(P<0.05)。治疗后,两组主观疼痛视觉模拟(VAS)评分、创面渗液积分、肉芽形态积分、肛管高压带长度、Wexner评分明显降低,而创面愈合率、创面组织VEGF、bFGF水平、肛管最大收缩压、肛管舒张压、肛管静息压明显升高,且联合组各项指标降低或升高幅度大于对照组,差异有统计学意义(均P<0.05)。结论:苦参汤熏洗联合马应龙麝香痔疮膏能加快MH术后创面愈合,缓解术后疼痛症状,促进肛门功能恢复,其机制可能与上调创面组织中VEGF、bFGF表达有关。     

参麻益智胶囊治疗老年血管性痴呆的临床研究

为了观察参麻益智胶囊治疗老年血管性痴呆（VD）的临床疗效。将68例VD患者随机分为治疗组和对照组,治疗组用参麻益智胶囊,对照组用西药喜得镇,采用双盲双模拟法给药。结果参麻益智胶囊可以明显改善临床症状,提高智量表积分,改善患者记忆认知功能,恢复患者神经功能缺损,改善日常生活能力,血液流变学指标及脑部功能活动状态,其中在改善临床症状方面治疗组明显优于对照组（P＜0．05）,说明参麻益智胶囊治疗老年血管性痴呆疗效肯定,在观察中未发现有任何毒副作用。     

肉苁蓉提取工艺及干燥方式研究

目的选择肉苁蓉最佳提取工艺参数,研究不同干燥方式对5种苯乙醇苷类成分的影响。方法采用单因素筛选结合Box-Behnken响应面法优化提取工艺。最优条件提取后,利用HPLC法检测不同干燥方式肉苁蓉的松果菊苷、肉苁蓉苷A、毛蕊花糖苷、异毛蕊花糖苷、2′-乙酰基毛蕊花糖苷成分含量并采用单因素方差分析、聚类分析、主成分分析、密切值法分析5种苯乙醇苷类成分含量,选择最佳干燥方式。结果最佳提取工艺:甲醇体积分数55.14%,液料比46.39,提取时间38.50 min。聚类分析、主成分分析、密切值法分析表明,采用冷冻干燥法所得到的肉苁蓉品质最好,80℃烘干次之,40℃烘干最低。结论使用该工艺提取肉苁蓉,其5种苯乙醇苷类成分提取完全、充分。虽然冷冻干燥法炮制肉苁蓉所保留有效成分最高,但从生产角度考虑,采用80℃烘干法炮制能达到成本和功效的平衡。     

肉苁蓉化学成分的研究

从列当科植物肉苁蓉Ｃｉｓｔａｎｃｈｅ ｄｅｓｅｒｔｉｃｏｌａ中分得１０个化合物,通过理化常数,光谱数据及Ｘ－衍射分别鉴定为苁蓉素,梓醇,丁香苷,红景天苷,２,５－二氧－４－咪唑烷基－氨基甲酸,甘露醇,硬脂酸,β－谷甾醇,胡萝卜苷和甜菜碱。其中Ⅴ为新的天然产物,Ⅱ为首次从本属植物中分得,Ⅰ,Ⅲ,Ⅳ为首次从该种植物中分得。     

Chemical Constituents from Stems of Cistanches deserticola

Objective To study the chemical constituents in the stems of Cistanches deserticola. Methods The compounds were purified by various column chromatographic methods and their structures were elucidated by spectroscopic(1D, 2D NMR, IR, [?]D, and MS) and chemical analyses. Results Seven compounds were isolated and identified as kankanoside D1(1), ajugol(2), cistanin(3), uridine(4), adenosine(5), 6-deoxycatalpol(6), and kankanoside D(7). Conclusion Compound 1 is a new compound.     

The quality of information available about Ephedra sinica on online vendor websites: The Canadian consumer experience

BackgroundEphedra sinica (ES) is a natural health product used to promote weight loss, enhance athletic performance, and treat common ailments such as the common cold or flu. Due to restrictions within Canada, Canadians interested in purchasing this product turn to online vendors for the ease and discrete nature of online transactions. However, the information available on these websites for consumers looking to purchase the substance is variable. This study investigated the quality of information about ES available to Canadian consumers on the websites of these online vendors.MethodsFollowing searches on Google.ca, eligible websites were assessed using the DISCERN instrument, a tool consisting of 16 questions, each rated on a five-point Likert scale, to assess the quality of health information about a treatment choice. The data was used to determine the overall quality of information about ES available to consumers on these websites.ResultsA total of 660 webpages were identified, of which 28 websites were found to be eligible. It was determined that the overall quality of information of websites selling ES products online was poor, as 79 % of online vendors received an average score of 2 or below.ConclusionConsumers looking to purchase ES online are lacking critical information about this herbal product that is necessary to make an informed decision about its use. This study's findings can be used by clinicians and researchers to inform patients about the poor quality of information about ES on these websites and help them identify quality sources of information.     

八角麻的抗炎、镇痛、解热作用

口服八角麻酒提取物,对大鼠角叉菜胶性足肿胀和棉球肉芽肿有明显的抗炎作用,LD50为1290±238g/kg;角叉菜胶性足肿胀的ED50为111.4±42.1g/kg。小鼠醋酸扭体法的ED50为47.1±16.9g/kg,并与大鼠k~+透入测痛法等实验结果均有镇痛作用。以DNP为致热剂的大鼠发热试验,有较强的解热作用,但对大鼠正常体温没有明显影响。