全文获取类型
收费全文 | 9728篇 |
免费 | 539篇 |
国内免费 | 700篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 41篇 |
妇产科学 | 24篇 |
基础医学 | 569篇 |
口腔科学 | 120篇 |
临床医学 | 1015篇 |
内科学 | 142篇 |
皮肤病学 | 20篇 |
神经病学 | 364篇 |
特种医学 | 606篇 |
外科学 | 4341篇 |
综合类 | 1663篇 |
预防医学 | 239篇 |
眼科学 | 126篇 |
药学 | 547篇 |
10篇 | |
中国医学 | 1021篇 |
肿瘤学 | 110篇 |
出版年
2024年 | 74篇 |
2023年 | 220篇 |
2022年 | 305篇 |
2021年 | 375篇 |
2020年 | 365篇 |
2019年 | 247篇 |
2018年 | 279篇 |
2017年 | 319篇 |
2016年 | 339篇 |
2015年 | 366篇 |
2014年 | 854篇 |
2013年 | 747篇 |
2012年 | 764篇 |
2011年 | 705篇 |
2010年 | 700篇 |
2009年 | 556篇 |
2008年 | 445篇 |
2007年 | 439篇 |
2006年 | 414篇 |
2005年 | 325篇 |
2004年 | 313篇 |
2003年 | 303篇 |
2002年 | 241篇 |
2001年 | 189篇 |
2000年 | 140篇 |
1999年 | 180篇 |
1998年 | 102篇 |
1997年 | 91篇 |
1996年 | 85篇 |
1995年 | 77篇 |
1994年 | 68篇 |
1993年 | 64篇 |
1992年 | 42篇 |
1991年 | 28篇 |
1990年 | 14篇 |
1989年 | 23篇 |
1988年 | 19篇 |
1987年 | 18篇 |
1986年 | 26篇 |
1985年 | 18篇 |
1984年 | 13篇 |
1983年 | 6篇 |
1982年 | 13篇 |
1981年 | 11篇 |
1980年 | 11篇 |
1979年 | 9篇 |
1978年 | 6篇 |
1977年 | 6篇 |
1976年 | 5篇 |
1971年 | 3篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
目的探讨经椎间孔入路经皮内窥镜下腰椎椎间盘切除术(PETD)治疗腰椎椎间盘突出症(LDH)的临床疗效,并探讨影响患者预后的相关因素。方法采用前瞻性队列研究设计,纳入2015年8月—2016年9月诊断为LDH并行PETD治疗的102例患者。分别于术前1 d及术后1 d、3个月、6个月、12个月、36个月时评估疼痛视觉模拟量表(VAS)评分、Oswestry功能障碍指数(ODI)、日本骨科学会(JOA)评分,采用改良MacNab标准评估临床疗效。分析患者临床特征和影像学资料等因素对预后的影响。结果86例患者完成36个月及以上随访,其中男56例、女30例,年龄19~88(46.96±14.03)岁,随访36~46(40.91±3.21)个月。86例患者手术顺利完成,无术中转开放手术。并发症发生率为1.2%(1/86),复发率为5.8%(5/86)。术后1 d、3个月、6个月、12个月、36个月,腰痛和腿痛VAS评分及ODI均较术前下降,JOA评分较术前升高,差异均有统计学意义(P<0.05)。根据改良MacNab标准,术后36个月优良率为94.2%(81/86)。突出髓核(HNP)越大,术后腿痛VAS评分、ODI和JOA评分改善越明显,差异有统计学意义(P<0.05);与体质量指数(BMI)<25 kg/m^2的患者相比,BMI≥25 kg/m^2的患者JOA评分改善较小,差异无统计学意义(P>0.05)。结论PETD治疗LDH可取得满意疗效。HNP大小是影响患者预后的主要因素,BMI可能对预后也有一定影响,但尚需扩大样本量进一步研究。 相似文献
102.
目的 探讨微创经椎间孔入路腰椎椎间融合术(MIS-TLIF)中横突定位法置钉治疗腰椎退行性疾病的可行性.方法 回顾性分析2017年1月—2019年5月在新华医疗集团新华医院接受MIS-TLIF治疗的70例腰椎退行性疾病患者的临床资料,其中采用横突定位法置钉33例(观察组),采用传统人字嵴定位法置钉37例(对照组).记录并比较2组术中出血量、透视次数、置钉时间、一次置钉成功率、置钉优良率、关节突关节破坏率,在术前、术后3个月和末次随访时采用Oswestry功能障碍指数(ODI)、疼痛视觉模拟量表(VAS)评分评价患者腰椎功能及疼痛程度.结果 所有手术顺利完成,患者随访16~36(23.18±3.91)个月.观察组置钉时间、透视次数、关节突关节破坏率显著低于对照组,一次置钉成功率、置钉优良率显著高于对照组,差异均有统计学意义(P<0.05);术中出血量组间差异无统计学意义(P>0.05).2组术后3个月、末次随访时VAS评分和ODI均较术前显著改善,差异均有统计学意义(P<0.05),组间比较差异无统计学意义(P>0.05).结论 MIS-TLIF术中采用横突定位法置钉治疗腰椎退行性疾病近期疗效良好,可减少置钉时间,提高置钉成功率与准确率. 相似文献
103.
目的 分析不同年龄段非特异性腰痛患者人口学因素、临床特征及竖脊肌形态与腰椎曲度的相关性.方法 选取2016年1月—2019年12月首都医科大学附属北京安贞医院和国家电网北京电力医院收治的临床影像学资料完整的非特异性腰痛患者99例,记录患者年龄、性别、体质量指数(BMI)、腰痛持续时间、腰痛视觉模拟量表(VAS)评分.于腰椎侧位X线片测量腰椎前凸角,于腰椎横断面MRI测量L4,5节段去除脂肪信号后的双侧竖脊肌横截面积(CSA)及L4 CSA.依据患者年龄分为≥65岁组(16例)和<65岁组(83例),比较2组人口学因素、腰痛持续时间、VAS评分、竖脊肌参数和腰椎前凸角的差异,并分析腰椎前凸角与其他指标的相关性.结果 <65岁组L4,5节段竖脊肌CSA/L4 CSA高于≥65组,差异有统计学意义(P<0.05).2组性别、BMI、VAS评分、腰痛持续时间及腰椎前凸角差异无统计学意义(P>0.05).在<65岁组中,相关性检验显示性别和L4,5节段竖脊肌CSA/L4 CSA与腰椎前凸角存在相关性,多元线性回归分析显示腰椎前凸角与L4,5节段竖脊肌CSA/L4 CSA呈正线性相关.在≥65岁组中,相关性检验显示腰椎前凸角与年龄和L4,5节段竖脊肌CSA/L4 CSA存在相关性,多元线性回归分析显示年龄与腰椎前凸角呈负线性相关、与L4,5节段竖脊肌CSA/L4 CSA呈正线性相关.结论 非特异性腰痛患者性别、年龄、L4,5节段竖脊肌CSA/L4 CSA与腰椎曲度均存在相关性,<65岁的患者腰椎曲度与性别相关,≥65岁的患者腰椎曲度与年龄相关,而腰椎曲度与L4,5节段竖脊肌CSA/L4 CSA的相关性不依赖于年龄. 相似文献
104.
ObjectiveThe objective of the present study was to evaluate the safety and efficacy of percutaneous transforaminal endoscopic discectomy (PTED) and open fenestration discectomy (OFD) in the treatment of lumbar disc herniation (LDH).MethodsPatients in our hospital with LDH who received PTED (n = 71) and OFD (n = 39) from 2013 to 2014 were retrospectively studied. Patient information, including age, gender, visual analogue scale (VAS) score for low back pain and leg pain, body weight, height, Oswestry disability index (ODI), Japanese Orthopedic Association (JOA), and recurrence, was collected. The patients in the two groups were followed up for an average of 63 months after surgery.ResultsA total of 136 patients completed the operation and 110 patients were followed up completely. There was no significant difference in baseline data between the two groups (P > 0.05). The postoperative low back pain, leg pain, ODI, and JOA of the two groups were better than those preoperatively (P < 0.05). One week after surgery, the recovery of PTED patients was better than that of OFD. The ODI score of the PTED group was lower than that of the OFD group (10 [8, 12] vs 14 [11, 16]; P < 0.05), the waist VAS score of the PTED group was lower than that of the OFD group (2 [2, 3] vs 3 [2, 4]; P < 0.05), the leg VAS score of the PTED group was lower than that of the OFD group (1 [0,1] vs 1 [1, 2]; P < 0.05), while the JOA score of the PTED group was higher than that of OFD group [19(16, 20) vs 12(10, 17); P < 0.05]. There were no significant differences in ODI, JOA, waist and leg VAS scores between the two groups at 1 month after surgery and at subsequent follow‐up (P > 0.05). At the end of the follow up, 89.7% (35/39) of patients in the OFD group had excellent improvement in the JOA score, and 88.7% (63/71) of patients in the PTED group had an excellent improvement. There was no significant difference between the two (P > 0.05). There was also no significant difference in the recurrence rate between the two groups [(5/71) vs (3/39); P > 0.05]. [Correction added on 05 March 2021, after first online publication: “3/29” was amended to “3/39” in the preceding sentence.]ConclusionBoth PTED and OFD can achieve good mid‐term efficacy in the treatment of LDH but PTED has certain advantages, including the small incision, a shorter hospital stay, and quicker, earlier recovery. However, prospective randomized controlled studies with a larger sample size are needed. 相似文献
105.
Qingpeng Song Bao Hai Wenkui Zhao Xin Huang Kaixi Liu Bin Zhu Xiaoguang Liu 《Orthopaedic Surgery》2021,13(2):659
To (i) introduce the technical notes of a novel full‐endoscopic foraminotomy with a large endoscopic trephine for the treatment of severe degenerative lumbar foraminal stenosis at L5S1 level; (ii) assess the primary clinical outcomes of this technique; (iii) compare the effectiveness of this full‐endoscopic foraminotomy technique and other previous techniques for lumbar foraminal stenosis. From January 2019 to August 2019, a retrospective study of L5S1 severe degenerative lumbar foraminal stenosis was performed in our center. All patients who were diagnosed with severe foraminal stenosis at L5S1 level and failed conservative treatment for at least 6 weeks were identified. Patients with segmental instability or other coexisting contraindications were excluded. A total of 21 patients were enrolled in the study. All patients were treated by full‐endoscopic foraminotomy using large endoscopic trephine. The visual analogue scale (VAS) and Oswestry disability index (ODI) were evaluated preoperatively and at 1, 3, 6 months, and 1 year after the surgery, and the modified MacNab criteria were used to evaluate clinical outcomes at the last follow‐up. There were 10 males and 11 females with a mean age of 66.38 ± 9.51 years. Five patients had a history of lumbar surgery. The mean operative time was 63.57 ± 25.74 min. The mean follow‐up time was 13.29 ± 1.38 months. The mean postoperative hospital stay time was 1.29 ± 0.56 days. The mean preoperative VAS score significantly decreased from 7.38 ± 1.02 to 2.76 ± 1.09 (t = 19.759, P < 0.01), 2.25 ± 1.02 (t = 21.508, P < 0.01), 1.60 ± 1.05 (t = 31.812, P < 0.01), and 1.45 ± 1.10 (t = 25.156, P < 0.01) at 1 month, 3 months, 6 months, and 1 year after the operation. The mean preoperative ODI score significantly decreased from 64.66% ± 4.91% to 30.69% ± 4.59% (t = 33.724, P < 0.01), 29.44% ± 4.50% (t = 32.117, P < 0.01), 24.22% ± 4.14% (t = 33.951, P < 0.01), and 22.44% ± 4.94% (t = 30.241, P < 0.01) at 1 month, 3 months, 6 months, and 1 year after the operation. At the last follow‐up, 19 patients (90.48%) got excellent or good outcomes. One patient suffered postoperative dysesthesia, and the symptoms were controlled by conversion treatment. One patient took revision surgery due to the incomplete decompression. There were no other major complications. Percutaneous endoscopic decompression is minimally invasive spine surgery. However, the application of endoscopic decompression for L5S1 foraminal stenosis is relatively difficult due to the high iliac crest and narrow foramen. Full‐endoscopic foraminotomy with the large endoscopic trephine is an effective and safe technique for the treatment of degenerative lumbar foraminal stenosis. 相似文献
106.
IntroductionLumbar hernias are considered rare and they constitute less than 1.5% of all abdominal wall hernias.Case reportHere we present a case of a 72-year-old female with a left flank swelling since 2-years diagnosed as a lumbar incisional hernia. This lumbar incisional hernia1 was repaired successfully using polypropylene mesh strip sutures.2DiscussionMany surgical techniques have been described for repair of LIH. Suture repair, mesh repair and myofascial flaps have been described for lumbar hernias. Repairing a lumbar hernia can be surgically challenging because of its proximity to bony structures, which can limit proper dissection and mesh overlap. We performed defect closure with PMSS. Patient has no recurrence after 2 years of follow up.ConclusionIn our case of left lumbar incisional hernia, defect closure with PMSS was an effective operation. This technique may also be effective in potentially contaminated settings due to reduced implant load. Further studies are required to understand its biomechanics and long-term outcomes. 相似文献
107.
目的 探讨超声刀应用于后路脊柱显微内窥镜椎间盘摘除术(Microendoscopic Discectomy MED)治疗腰椎间盘突出症中的优势与疗效.方法 我院自2005年1月~11月将根据患者症状、体征、体查、CT和或MRI确诊的腰椎间盘突出症患者97例随机分为两组,超声刀 MED组45例,采用超声刀处理椎板下缘等骨性结构;而常规MED手术组52例采用枪钳或电动磨钻处理.结果 超声刀 MED组与常规MED组平均手术时间分别为42 min和75 min,平均术中失血量分别为29 ml和61 ml,平均术后引流量分别为13 ml和29 ml,差异均有显著性(P<0.05);两组所有病例获得13月(6~17月)随访,按Macnnab标准,优良率分别为95.6%和92.3%,差异无显著性(P>0.05).结论 超声刀切割骨骼的同时不损伤软组织,且有同步止血功能,操作安全方便,能缩短MED手术时间,不失为脊柱手术一种理想的辅助工具. 相似文献
108.
M. W. Berfelo 《European spine journal》1993,2(2):89-95
Summary A new kinematic concept is described that relates to the notion that the lumbar spine behaves as a complete structure. This concept is called the R-zero line and represents kinematically the neutral position of the lumbar spine between anteflexion and retroflexion. The clinical significance of this parameter is evaluated in normal individuals and in patients with a symptomatic herniated disc at L4–5, with a symptomatic herniated disc at L5–S1, and with spondylolysis/spondylolisthesis. The results of this study show that the R-zero line has a characteristic configuration in all four test groups. 相似文献
109.
张神虎 《辽宁中医药大学学报》2001,3(4):278-279
对女性输卵管结扎术后腰痛进行调查和病理分析 ,以中药配合医疗体育康复治疗术后腰痛 ,取得较好疗效 ,并提出预防措施。 相似文献
110.
前方牵引器结全方丝弓矫治器矫治前牙反He 总被引:1,自引:1,他引:0
目的:进一步了解前方牵引矫治器对前牙反的矫治效果.方法:选择17例安氏Ⅲ类病人,男7例,女10例,最大12.8岁,最小8.5岁,均为替牙期及恒牙早期,X线头影测量显示主要为上颌后缩及下颌轻度前突,头颅侧位片上颈椎多数显示为生长发育高峰前期.结果:平均疗程9.5个月,X线头影测量结果骨骼改变主要为SNA角增大,平均增大2.33°,ANB角增大,平均增大4.17°,SNB角减小,平均减小1.97°.统计学处理有显著性差异.结论:前方牵引矫治器有促进上颌骨向前生长,抑制下颌骨向前生长的作用;而其口内装置选用方丝弓矫治器主弓丝上焊牵引钩配合矫形牵引,使之更为方便简捷. 相似文献