丹参抗大鼠乙酸性十二指肠溃疡作用机制的探讨

目的　探讨丹参抗大鼠乙酸性十二指肠溃疡的作用及机制。方法　按Okabe方法复制大鼠乙酸十二指肠溃疡模型 ,按传统方法测定溃疡指数、溃疡抑制率 ;用放射免疫法测定十二指肠溃疡部位的前列腺环素 (PGI2 )含量。结果　丹参组的溃疡指数显著低于对照组 (P <0 .0 1) ,其溃疡抑制率高于对照组 ,PGI2 的含量亦显著高于对照组 (P <0 .0 1)。结论　丹参具有抗大鼠十二指肠溃疡的作用 ,其机制可能是丹参提高了十二指肠粘膜的防御能力     

幽门螺杆菌在成人消化性溃疡检出的探讨

目的：探讨幽门螺杆菌（HP）感染与消化性溃疡（PU）及年龄、性别的关系。方法：采用快速尿素酶和组织H-E染色法对119例PU病人进行HP感染检测，其中男性96例、女性23例，以上二种方法测定结果均阳性定为HP感染。然后将这些病例按年龄分为三组，即青年组33例，中年组78例和老年组8例。结果：HP总感染率：胃溃疡78．6％，十二指肠球溃疡63．6％，幽门管溃疡66．7％及复合溃疡62．5％，该结果与以前报道相同。各种溃疡的HP感染率在各年龄组间比较及男、女性别间比较无显著性差异（P均＞0．05）。结论：HP感染与PU关系密切，与性别无关，并不与年龄成正比上升。     

超氧化物歧化酶和脂质过氧化物与溃疡病发病关系

目的：观察超氧化物歧化酶（ＳＯＤ）和脂质过氧化物（ＬＰＯ）在消化性溃疡（ＰＵ）治疗前后变化，以探索其对ＰＵ发病和愈合作用。方法：用ＳＵＮ法和于树玉法分别测定ＰＵ患者血及组织中铜锌超氧化物歧化酶（Ｃｕ ＺｎＳＯＤ）活性和ＬＰＯ含量。结果：１８０例十二指肠溃疡（ＤＵ）和４２例胃溃疡（ＧＵ）患者粘膜和红细胞中Ｃｕ ＺｎＳＯＤ活性比正常组显著降低（Ｐ＜０．０１～０．００１）。１３６例ＤＵ组织及血中和１５例ＧＵ组织中ＬＰＯ含量比正常组显著升高（Ｐ＜００１～０．００１）。用呋喃唑酮、雷尼替丁和洛赛克分别治疗５０、２０和２４例ＤＵ患者两周后组织中Ｃｕ ＺｎＳＯＤ活性比治疗前明显升高（Ｐ＜０．０１～０．００１）。组织中ＬＰＯ含量比治疗前明显降低（Ｐ＜０００５～０．００１）。组织和红细胞中Ｃｕ ＺｎＳＯＤ活性从活动期→愈合期→瘢痕期逐渐升高，而ＬＰＯ含量则逐渐降低。结论：粘膜组织中Ｃｕ ＺｎＳＯＤ活性和ＬＰＯ含量升降与消化性溃疡的愈合和发病密切相关。     

贲门溃疡104例内镜检查分析

目的:通过贲门溃疡胃镜下表现的分析,探讨贲门良性溃疡与恶性溃疡的区别及并发症的差异.方法:纤维胃镜检查的同时采取相应部位的病理标本并行病理学检查,记数资料采用卡方检验比较差异性.结果:病例共104例,其中良性溃疡66例,恶性溃疡30例,癌前病变8例,恶性溃疡73%合并有慢性萎缩性胃炎,良性溃疡25%合并有十二指肠球部溃疡.结论:贲门良性溃疡(16/66)与十二指肠疾患密切相关,恶性溃疡(22/30)于慢性萎缩性胃炎密切相关,临床工作中遇有慢性萎缩性胃炎患者,应高度警惕,定期随访,及时发现恶变.     

The Clinical Effects of Alantoin Powder for Gargleon Periodontal Diseases and Aphthous Ulcer

ＴｈｅＣｌｉｎｉｃａｌＥｆｅｃｔｓｏｆＡｌａｎｔｏｉｎＰｏｗｄｅｒｆｏｒＧａｒｇｌｅｏｎＰｅｒｉｏｄｏｎｔａｌＤｉｓｅａｓｅｓａｎｄＡｐｈｔｈｏｕｓＵｌｃｅｒＹｕＷｅｉｙｉ（俞未一）ＳｕｎＷｅｉｂｉｎ（孙卫斌）ＤｅｐａｒｔｍｅｎｔｏｆＳｔｏｍａｔｏｌ...     

米索前列醇的临床应用

米索前列醇（misoprostol,米索）是人工合成的前列腺素E_1的衍生物,有多方面临床用途。80年代早期米索最先开始用于治疗消化性溃疡,尤其是对非甾体类抗炎药引起的胃十二指肠溃疡有明显疗效,对急性应激性溃疡也有预防作用。米索可引起腹泻,但因此也可治疗严重便秘的患者。随后发现米索对肝、肾有保护作用,还具明显抗炎、抗过敏作用;与其它抗早孕药合用,米索可使完全流产率大大提高;对人工流产术前的病人用米索可软化并扩张宫颈,从而减轻扩宫时病人的痛苦,使手术顺利进行。对米索的毒副作用研究发现其毒性主要表现在消化系统和雄性生殖系统,但一般比较轻微,无明显其它不良反应。故米索可谓一种高效、低毒的药物,值得临床推广。但男性患者在长期大量应用该药时需注意其对生殖系统的影响,孕妇应禁用。     

A Case of Postbulbar Duodenal Ulcer with Jaundice

Abstract: A 63-year-old man was hospitalized because of jaundice and anorexia. An upper gastrointestinal series and hypotonic duodenography revealed circumferential sclerosis and stenosis of the duodenal wall. Endoscopic examination disclosed an ulcer, the upper margin of which was located at the papilla of Vater. The papilla was situated in the base of the ulcer. Endoscopic retrograde cholangiopancreatography disclosed mild dilatation of the common bile, intrahepatic bile and pancreatic ducts, but with neither severe stenosis nor occlusion. Nevertheless, there was some degree of circumferential compression and mild stenosis of the terminal portions of the bile and pancreatic ducts, as potential causes of obstructive jaundice in this patient. Computed tomographic examination of the abdomen revealed a tumorous lesion at the duodenal bulb. Because malignancy in the duodenum could not be ruled out, a pancreatoduodenectomy was performed. Histopathological examination showed a postbulbar duodenal ulcer, associated with inflammation of the papillary orifice and fibrosis of the region near the papilla. There was no evidence of a tumorous lesion. In this case, a postbulbar duodenal ulcer may have caused obstructive jaundice.     

磷酸铝凝胶剂的研制

以微粒沉降速度、粒度分布、粘度大小等为指标，利用正交试验法筛选出磷酸铝凝胶剂的最佳处方。结果表明，磷酸铝凝胶剂的沉降容积比可达９３．１％，其粒度均小于１０μｍ，而且沉降速度较小。     

Combined laparoscopic and endoscopic treatment of perforated gastroduodenal ulcer using the ligamentum teres hepatis (LTH)

We propose a novel technique for laparoscopic treatment of perforated gastroduodenal ulcers. The principle of this procedure involves the closure of the perforated ulcer using the ligamentum teres hepatis (LTH). The LTH is cut near its umbilical end and then dissected up to the site of its hepatic insertion. The umbilical extremity of LTH is grasped with a Dormia noose passed through the ulcerated perforation via a gastroscope. Using the noose, the LTH is pulled through the ulcerated perforation until its volume fits and completely closes the perforation. This laparoscopic technique was performed in 15 patients (12 M, 3 F) with anterior perforated duodenal ulcer revealed within the previous 6 h. The procedure could not be performed in three cases: diameter of the perforation exceeding 1.5 cm (n=1), general purulent peritonitis (n=2). In the other 12 cases, closure of the ulcerated perforation with the LTH was realized without technical difficulty. The postoperative course was uncomplicated. The posttreatment comfort was excellent; the mean period of hospitalization was 10 days (range, 8–14 days). An endoscopic examination carried out following 5 weeks of anti-H2 treatment showed that cicatrization of the ulcer was good and that no pyloric stenosis remained. These initial results suggest that laparoscopic treatment of perforated gastroduodenal ulcer using the LTH is a simple procedure which can be performed with general assurance of success in patients whose perforated ulcers have occurred quite recently. As the laparoscopic procedure is less aggressive than a laparotomy, it enhances the postoperative comfort of patients and prevents the risk of parietal complications. Compared to laparoscopic endosuture this procedure is simple, effective, easier, and particularly adapted to large ulcerated perforation or when an ulcer's edges are tough or friable, tending to tear when knots are tied.Presented at the annual meeting of the Society of American Gastrointestinal Endoscopic Surgeons (SAGES), Nashville, TN, USA, 18–19 April 1994.     

Ultrastructure of another spiral organism associated with human gastritis

Summary Campylobacter pylori may not be the only organism that causes active chronic gastritis in man. We report two cases of gastric infection with a spiral organism distinct fromC. pylori. The first patient is a 36-year-old female who presented with epigastric pain and abdominal colic present since childhood and who had 14 cats. Endoscopy was normal. The second patient kept two dogs. Histology of gastric mucosal biopsy specimens in both patients revealed active chronic gastritis, most severe in body mucosa. Giemsa stain revealed bacteria with four to eight spirals, 0.5 m in diameter and 3–7 m in length. The organisms had multiple sheathed flagella at the pole and smooth cell walls without axial filaments. The organisms resembled the gastric spirillum that has been seen in cats, dogs, and nonhuman primates. After antibacterial therapy with bismuth subsalicylate, amoxicillin, and metronidazole, the organisms disappeared in both patients and the gastritis healed.UnlikeC. pylori, this new spirillum prefers to colonize gastric mucosa containing parietal cells. Whereas this type of organism is a common commensal in other mammals, it appears to be associated with and a possible cause of gastritis in humans.