Systematic review of the effects of maternal hypertension in pregnancy and antihypertensive therapies on child neurocognitive development

As many as 15% of women experience hypertension during pregnancy. Large proportions of them are receiving antihypertensive medications. This review investigated whether hypertension itself, or the antihypertensive medications, adversely affect long term child neurocognitive development. The existing evidence suggests that methyldopa and labetalol probably do not adversely affect neurobehavioral development. Although an increasing body of evidence suggests adverse neurocognitive effects of the hypertension itself, none of the existing studies examined simultaneously the effects of both hypertension and the drugs used therapeutically. The confounding effects by indication must be addressed in future studies.     

Synthesis and in vitro pharmacological activity of oxypropanol analogs of labetalol

New oxypropanol alpha- and beta-adrenoceptor blocking agents, analogs of labetalol, were synthesised and studied in vitro in left atria and aorta for alpha and beta activity.     

柳胺苄心定对老年人诱导插管期间血流动力学的影响

目的：观察柳胺苄心定（Ｌａ）在全麻诱导插管期间对老年人血流动力学的影响。方法：２０例老年择期手术病人随机分Ｌａ组（Ｌ组）和对照组（Ｓ组），每组１０例。全麻诱导前分别静脉注射Ｌａ０．５０ｍｇ／ｋｇ和等容生理盐水，后静脉诱导插管。测定用药前至插管后５分钟内不同时间的血流动力学变化。结果：０．５０ｍｇ／ｋｇＬａ能使ＢＰ、ＨＲ、ＳＶＲＩ轻度下降，插管后即刻Ｌ组的ＢＰ、ＨＲ、ＲＰＰ升高幅度比Ｓ组小，组间比较有显著性差异。结论：Ｌａ能大部分阻断插管刺激引起的心血管不良反应。     

川芎嗪注射液联合拉贝洛尔治疗妊娠期高血压的临床研究

目的探讨川芎嗪注射液联合拉贝洛尔治疗妊娠期高血压的临床效果。方法选取兴宁市妇幼保健院2015年3月—2016年12月收治的妊娠期高血压患者98例,随机分为对照组与治疗组,每组各49例。对照组患者静脉滴注盐酸拉贝洛尔注射液,50 mg加入5%葡萄糖溶液250 m L中,1次/d。治疗组患者在对照组的基础上静脉滴注盐酸川芎嗪注射液,120mg加入5%葡萄糖溶液250 m L,1次/d。两组患者均治疗10 d。评价两组患者临床疗效,同时比较治疗前后两组患者血压、血浆黏度、24 h蛋白尿定量、尿素氮(BUN)、尿微量清蛋白(MA)、超敏C反应蛋白(hs-CRP)和同型半胱氨酸(Hcy)水平变化情况。结果治疗后,对照组和治疗组总有效率分别为79.59%、93.88%,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者舒张压和收缩压均明显下降(P0.05);且治疗组患者的血压水平明显优于对照组(P0.05)。治疗后,两组患者血浆黏度、24 h蛋白尿定量和MA水平均明显降低(P0.05);且治疗组患者上述观察指标水平明显低于对照组(P0.05)。治疗后,两组患者血清hs-CRP和Hcy水平均显著降低(P0.05);且治疗组患者hs-CRP与Hcy水平显著低于对照组(P0.05)。结论川芎嗪联合拉贝洛尔治疗妊娠期高血压疗效显著,且具有较高的安全性,具有一定的临床推广应用价值。     

拉贝洛尔治疗妊娠期高血压对母婴预后的影响

目的：观察拉贝洛尔治疗妊娠并高血压对母婴预后的影响。方法将220例患有妊娠高血压的患者随机分为观察组和对照组各110例,对照组患者均给予常规治疗,观察组患者在此基础上加用拉贝洛尔进行治疗,治疗结束后测定2组患者血压情况以及分娩结局。结果治疗后2组患者的收缩压与舒张压较治疗前均有显著下降,观察组下降幅度大于对照组,差异均有统计学意义（P＜0.05）。2组新生儿体质量差异无统计学意义（P＞0.05）;观察组患者产后出血、早产、新生儿宫内窘迫发生率均显著低于对照组,差异均有统计学意义（ P＜0.05）,结论拉贝洛尔治疗妊娠高血压,能够有效地控制血压,减少并发症的发生。     

Pharmacological management of malignant hypertension

ABSTRACT

Introduction

According to current guidelines, malignant hypertension is one of the emergencies in hypertension. The definition requires the presence of bilateral retinal hemorrhages or exudates, with or without papilledema, acute heart failure and acute deterioration in renal function in severe hypertension. Patients with malignant hypertension are characterized by pronounced target organ damage, including structural and functional cardiac abnormalities and renal insufficiency.     

Labealol in the treatment of stable exertional angina pectoris: a comparison with nifedipine

Labetalol, a combined alpha-and beta-receptor antagonist, wascompared with nifedipine in a placebocontrolled, randomizeddoubled-blind cross over study (four week treatment periods) of 11 normotensive patients with stable exertional anginapectoris. Standard recomended doses of both drugs (labetalol200–400 mg twice daily, nifedipine 10–20 mg threetimes daily) were used. Angina frequency was similar duringthe placebo washout period and treatment with the two drugs.The duration of treadmill exercise to angina, ischaemia (>1mm ST segment depression), and end of exercise was increasedby both labealol and nifedipine when compared with placebo,but there was no difference between the drugs. Ambulatory STsegment monitoring demonstrated that the frequency, durationand magnitude of ST segment depression, whether painful or silent,were unaffected by either drug. Labetalol is an effective agent in improving exercise tolerancein normotensive patients with stable exertional angina pectoris,with an efficacy similar to that of nifedipine.     

静脉滴注拉贝洛尔对老年高血压急症疗效及安全性的观察

目的评估静脉滴注拉贝洛尔治疗老年高血压急症的临床疗效及安全性分析。方法本文以64位老年高血压急症患者为研究对象,给予静脉滴注拉贝洛尔(1~4mg/min)降压治疗。结果治疗前血压为(205.69±25.42)/(111.24±15.91)mmHg。拉贝洛尔治疗2h后81.3%(50/64)患者平均血压下降15%~25%,治疗6h后血压控制在21.3/13.3kPa以下者为94%,拉贝洛尔降压起效快且无低血压现象发生。结论静脉滴注拉贝洛尔治疗老年高血压急症有效、安全。     

硫酸镁联合拉贝洛尔治疗妊娠高血压的疗效及对妊娠结局的影响

目的 探讨妊娠高血压患者应用硫酸镁联合拉贝洛尔的疗效及对妊娠结局的影响。方法 将我院2018年1月至2019年12月期收治的56例妊娠高血压患者随机分为观察组(28例,给予硫酸镁联合拉贝洛尔治疗)与对照组(28例,给予单纯硫酸镁治疗),观察治疗后的临床疗效及母婴结局。结果 观察组收缩压为(135.61±6.24)mmHg,低于对照组的(142.62±8.75)mmHg,舒张压为(86.63±4.19)mmHg,低于对照组的(92.47±5.86)mmHg,其治疗总有效率为92.86%,明显高于对照组的67.86%,其剖宫产、早产及产后出血发生率分别为17.86%、7.14%、10.71%,均低于对照组的50.00%、35.71%、38.28%,观察组胎儿窒息、宫内窘迫发生率分别为0、7.14%,低于对照的21.43%、32.14%,差异均有统计学意义(P0.05);两组胎儿死亡发生率比较,差异无统计学意义(P0.05)。结论 硫酸镁联合拉贝洛尔可有效控制妊娠高血压患者的血压水平,提高临床治疗的总有效率,改善母婴结局。