狼疮肾炎患者anti-GBM与anti-dsDNA和anti-NuA相关性研究

目的探讨狼疮肾炎患者抗肾小球基底膜抗体(anti-GBM)与抗双链DNA抗体(anti-ds DNA)和抗核小体抗体(anti-NuA)的关系。方法反馈分析28例anti-GBM阳性的狼疮肾炎患者致肾炎抗体间的关系。结果28例anti-GBM阳性的狼疮性肾炎患者有13例anti-ds DNA阳性和17例anti-NuA阳性。并且,血清anti-GBM的水平与anti-ds DNA和/或anti-NuA水平一致。结论anti-GBM与anti-ds DNA和anti-NuA呈正相关;联合检测这些肾炎抗体对疾病的治疗和预后判断有指导意义。     

中西医结合治疗狼疮性肾炎27例

目的:观察中西医结合治疗狼疮性肾炎的疗效。方法:将53例患者随机分为中西结合治疗组(治疗组)27例,西医治疗组(对照组)26例。对照组用激素标准疗程、环磷酰胺冲击治疗;治疗组在西医治疗的基础上辨证加用中药治疗。结果:治疗组有效率92.6%,对照组69.2%(p<0.05),对照组副作用及复发率均明显高于治疗组。结论:中西医结合治疗狼疮性肾炎可提高疗效,减少副作用的发生,降低复发率。     

Lithium normalizes elevated intracellular sodium

BACKGROUND: Both mania and bipolar depression are characterized by elevations of intracellular sodium concentrations. This observation has been purported to be central to the pathophysiology of abnormal moods in bipolar illness. Reduction of sodium influx is a proposed shared mechanism of action of effective mood stabilizers, but direct documentation of this effect for lithium has never been demonstrated. METHODS: Flame spectroscopic determinations of intracellular sodium concentration were performed in the human glioma cell line, LN292, after treatment with the sodium pump inhibitor, ouabain, and co-treatment with ouabain and lithium. RESULTS: Ouabain 0.1 microM doubles the intracellular sodium concentration after 3 days. Pretreatment with lithium 1 mM for 1 week normalizes intracellular sodium. CONCLUSION: This is the first demonstration that lithium can normalize abnormally elevated intracellular sodium levels. This may be an important mechanism of lithium action.     

EGFR、PCNA、LN、IV型胶原在SACC中的表达及临床意义

目的：探讨表皮生长因子受体（EGFR）、增殖细胞核抗原（PCNA）、层黏连蛋白（LN）和IV型胶原蛋白在唾液腺腺样囊性癌（SACC）中的表达及临床意义。方法：选取临床病例资料齐全的SACC 78例,用荧光原位杂交技术检测EGFR基因表达,免疫组织化学技术检测 EGFR、PCNA、LN和Ⅳ型胶原蛋白的表达,分析其与临床病理参数的相关性。结果：SACC中EG-FR基因扩增率（69．2％）与蛋白的阳性表达率（71．8％）存在明显正相关（P＜0．05）,且EGFR、PCNA、LN、Ⅳ型胶原蛋白表达与临床病理参数密切相关。EGFR、PCNA表达水平间存在明显正相关（P＜0．05）;LN蛋白、Ⅳ型胶原表达水平间存在明显负相关（P＜0．05）。结论：EGFR基因在SACC中明显扩增,EGFR、PCNA、LN、Ⅳ型胶原蛋白共同参与SACC发生、发展。     

尿MCP-1、细胞免疫水平检测对狼疮性肾炎患者病情评估的价值及相关性研究

目的探讨尿单核细胞趋化蛋白-1(MCP-1)、细胞免疫水平检测对狼疮性肾炎(LN)患者病情评估的价值及相关性。方法回顾性分析2011年9月~2016年9月60例就诊于我院肾内科的LN患者临床资料,依据系统性红斑狼疮疾病活动指数(SLE-DAI)将60例患者分为活动组(SLE-DAI评分≥10分,n=37)和稳定组(SLE-DAI评分10分,n=23);以同时期30例健康志愿者作为健康组。比较三组受试者尿MCP-1水平和外周血T细胞亚群(CD3~+、CD4~+、CD8~+、CD4~+/CD8~+)检测结果差异;经Pearson线性相关分析法分析尿MCP-1、T细胞亚群水平与LN患者病情严重程度的相关性。结果三组受试者尿MCP-1、外周血CD8~+检测结果显示:活动组稳定组健康组(P0.05);外周血CD4~+、CD4~+/CD8~+检测结果则显示:活动组稳定组健康组(P0.05);三组外周血CD3~+检测差异无统计学意义(P0.05)。Pearson线性相关分析结果显示:尿MCP-1水平、CD8~+水平与SLE-DAI评分呈正相关,CD4~+、CD4~+/CD8~+水平与SLE-DAI评分呈负相关(P0.05),CD3~+水平与SLE-DAI评分无明显相关性(P0.05)。结论尿MCP-1和T细胞亚群水平与LN患者病情严重程度关系密切,可作为LN诊断和病情评估的敏感指标。     

Hormonal changes and their impact on cognition and mental health of ageing men

Demographic changes resulting in ageing of the world's population have major implications for health. As men grow older, circulating levels of the principal androgen or male sex hormone testosterone (T) decline, while the prevalence of ill-health increases. Observational studies in middle-aged and older men have shown associations between lower levels of T and poorer mental health in older men, including worse cognitive performance, dementia and presence of depressive symptoms. The role of T metabolites, the more potent androgen dihydrotestosterone (DHT) and the oestrogen receptor ligand estradiol (E2) in the pathophysiology of cognitive decline are unclear. Studies of men undergoing androgen deprivation therapy in the setting of prostate cancer have shown subtle detrimental effects of reduced T levels on cognitive performance. Randomised trials of T supplementation in older men have been limited in size and produced variable results, with some studies showing improvement in specific tests of cognitive function. Interventional data from trials of T therapy in men with dementia are limited. Lower levels of T have also been associated with depressive symptoms in older men. Some studies have reported an effect of T therapy to improve mood and depressive symptoms in men with low or low-normal T levels. T supplementation should be considered in men with a diagnosis of androgen deficiency. Beyond this clinical indication, further research is needed to establish the benefits of T supplementation in older men at risk of deteriorating cognition and mental health.