气管、肺（060153～060223）

中国肺癌死亡趋势分析及发病、死亡的估计与预测；树突状细胞对自体CIK细胞体外杀伤肺腺癌细胞影响的研究；中国非小细胞肺癌患者表皮生长因子受体突变的研究；中期因子蛋白在非小细胞肺癌中的表达及临床意义；非小细胞肺癌组织中VEGF-C和VEGFR-3的表达及临床意义；应用组织芯片技术检测KAI1、MRP-1、FAK蛋白在肺癌组织中的表达；[编者按]     

封闭配合中药离子导入治疗第3腰椎横突综合征

目的探讨第3腰椎横突综合征的治疗效果。方法运用封闭加中药离子局部导入治疗第3腰椎横突综合征86例。结果痊愈69例,占80.24%,好转15例,占17.44%,无效2例,占2.32%,总有效率97.68%。结论治疗第3腰椎横突综合征封闭加中药离子导入是一种值得推广的方法。     

惠氏提交肾癌新药Torisel的上市申请

惠氏近日向美国和欧盟提交了肾细胞癌治疗药Torisel的上市申请。Torisel为mTOR抑制剂类药物,它是此类药物中首个申请用于治疗癌症的产品。其Ⅲ期临床试验结果显示,与α干扰素(目前治疗肾细胞癌的常规药物)疗法相比,Torisel可将中位生存期延长3.6个月(增加50%)。FDA已将Torisel指定为快批产品。因此若审批程序能按计划进行,该药最快将于2007年上半年在美国获准。惠氏提交肾癌新药Torisel的上市申请     

鱼油和心血管病

编辑先生:贵刊前几期刊登了含有ω-3的深海鱼油和马齿苋等对心血管有很好的保健作用,在2005第十“期养生月报”刊登的一文讲ω-3对心血管的作用正好相反,鱼油含ω-3不能吃了。请问马齿苋与核桃都含植物ω-3,还能吃吗?此致敬礼湖南财经高等专科学校李履琦李履琦先生:您好!心血管     

重组2型腺相关病毒-转化生长因子β3对实验性肝纤维化大鼠肝脏组织病理学和Ⅰ型胶原表达的影响

Objective To investgate the effects of TGF β 3 on rat hepatic fibrosis. Methods The TGF β 3 cDNA was cloned into rAAV2 vector. Rats were randomly divided into four groups: normal control group, model group, negative control group and TGF β 3 group. Hepatic fibrosis was induced by hypodermic injection of 40% CCI4. Recombinant AAV2-TGF β 3 viral particles were injected via the vena caudalis one week before CCh treatment. Rats were executed 8 weeks after CCI4 treatment, global histological change was observed after HE staining, the distribution of the collagen fibers was observed after masson staining, his-tochemistry was done to observe the expression of collagen Ⅰ; The positive area rate of the collagen fibers and the average optical rate of collagen Ⅰ were quantified. Results HE staining indicated that collagen fibers were reduced in the TGF β 3 group. Masson staining shown that the collagen fibers were distributed around the blood vessel, in the portal area and disse space. Compared to the model group (13.2%±2.2%) and negative control group (12.3%±1.5%), the collagen fibers in liver tissues of TGF β3 group (7.7% ± 1.5%) were significantly decreased (q = 9.456, P < 0.01; q = 8.217, P < 0.01). Histochemistry indicated that the collagen fibers of liver tissues of TGF 15 3 group (0.185±0.033) were significantly higher than those in the model group (0.252±0.042) and the negative control group (0.230±0.029), (q = 6.228, P < 0.01; q = 4.346, P < 0.01). Conclusion TGF β 3 alleviates the damage to hepatic cell and the level offibrosis in CCI4 treated rats and inhibits the expression of collagen Ⅰ.     

变质甘蔗中毒病原菌节菱孢霉菌及其毒素国内研究进展

变质甘蔗中毒病原菌节菱孢霉菌及其毒素国内研究进展赵秀勉，徐玮，张海红河北省人民医院（０５００５１）石家庄市卫生防疫站关键词变质甘蔗；中毒；节菱孢霉菌；毒素；３－硝基丙酸变质甘蔗中毒自１９７２年在我国首次报告以来［１］，已于我国１３个省和自治区发现。该...     

单胺氧化酶抑制剂治疗帕金森病新进展

60年代左旋多巴(L-dopa)的出现开辟了帕金森病(PD)治疗的新纪元,但随后认识到L-dopa不但副作用较多,且可加剧PD神经元变性。因而,寻找可阻止或延缓PD病情进展的药物成为神经病学科最有挑战性的问题之一。此问题的解决,可使对PD的治疗以治标上升到治本,80年代新兴的神经保护剂使之成为可能。 疾病的预防有赖于对致病原因的认识。目前,对PD神经元变性机理的认识,公认的有二种假说:自由基假