腹腔注射攻毒在蜱媒脑炎病毒感染BALB/c小鼠中的应用

目的 研究腹腔注射攻毒在蜱媒脑炎病毒（TBEV）感染BALB/c小鼠中的应用。方法 TBEV以103、104空斑形成单位（PFU）的攻毒剂量经腹腔注射感染BALB/c小鼠,观察小鼠的感染症状、体重变化与生存率。通过H-E染色显示小鼠脑、脾的病理改变,采用免疫组织化学检测小鼠脑、脾中TBEV蛋白的表达,空斑实验检测小鼠脑、脾中病毒滴度的动态变化。结果 TBEV感染第3天小鼠体重开始下降,第6天104 PFU组小鼠出现弓背、后肢瘫痪症状,第7天104 PFU组小鼠开始死亡,第9天103 PFU组小鼠全部死亡。与对照组小鼠相比,感染组小鼠的体重在第5~8天降低具有显著性差异（P<0.05或P<0.001）;小鼠生存率降低差异显著（P<0.01）。TBEV蛋白动态表达于感染组小鼠的脑与脾。103 PFU TBEV感染第7天,小鼠脑内TBEV滴度高达（1.3?0.6）×105 PFU/mL,而脾中滴度为（1.3?0.6）×103 PFU/mL。结论 经腹腔注射攻毒,TBEV在BALB/c小鼠体内建立感染,可增殖并具致病性。     

复方苦参注射液联合化疗对晚期胃癌患者生活质量的影响

目的：观察复方苦参注射液联合化疗对晚期胃癌患者生活质量影响。方法：回顾性分析70例晚期胃癌患者的治疗,治疗组化疗联合复方苦参注射液20ml＋生理盐水250ml,静脉滴注1次／d,连续2周,对照组单用化疗,每3周重复,共4个治疗周期,观察治疗前后疼痛、体重、食欲、karnofsky评分。结果：在控制疼痛、食欲改善方面,治疗组均优于对照组,差异有显著性（P〈O．05）;体重治疗前后比较差异无统计学意义（P〉0．05）。结论：复方苦参注射剂联合化疗能缓解疼痛,改善症状,提高患者生存质量。     

应用改良方法气管内滴入肺表面活性物质治疗新生儿肺透明膜病的疗效观察

目的：观察改良方法气管内滴入肺表面活性物质（pulmonary surfactant,PS）治疗新生儿肺透明膜病（Neonatal Hyaline Membrane Disease,HMD）的疗效。方法：选取96例新生儿肺透明膜病患儿,按随机数字表法分为治疗组（n=48）和对照组（n=48）,对照组采用传统的多体位间断非密闭式气管内滴入PS;治疗组应用经头皮针气管导管侧壁刺入持续气管内滴入PS,观察比较两组的各观察指标及临床转归情况。结果：治疗组的平均操作时间明显少于对照组,差异有统计学意义（P〈0.05）;且滴药过程中脱管率、管口溢药率、脉搏氧饱和度下降率及呼吸机相关性肺炎（VAP）发病率均明显低于对照组,差异均有统计学意义（P〈0.05）。结论：应用改良方法即经头皮针气管导管侧壁刺入持续气管内滴入PS成功率高,操作简单、快速,注药过程平缓,减少了脱管、药液喷出浪费、一过性缺氧及VAP的发生,是一种更快捷、方便、安全、经济、有效的给药方法,值得推广。     

丹参注射液与异甘草酸镁抗肝纤维化的临床对比研究

目的 观察慢性乙型肝炎患者应用丹参注射液和异甘草酸镁治疗后肝功能和肝纤维化指标的改善情况.方法 将80例慢性乙型肝炎患者,随机分为丹参组40例,异甘草酸镁组40例,在常规保肝治疗基础上,两组分别加用丹参注射液和异甘草酸镁注射液治疗,疗程均为30 d.观察两组患者治疗前、后的肝功能和肝纤维化指标[血清透明质酸酶(HA)、层黏连蛋白(LN)、Ⅳ型胶原(Ⅳ-C)]的变化.结果 治疗后丹参注射液和异甘草酸镁均可明显改善慢性乙型肝炎患者的肝功能,异甘草酸镁组较丹参组为优(P<0.05).丹参组肝纤维化指标较治疗前有下降(P<0.05);异甘草酸镁组肝纤维化指标与治疗前比较差异无统计学意义(P>0.05);两组治疗后的肝纤维化指标比较,差异有统计学意义(P<0.05).结论 丹参注射液改善肝纤维化的疗效优于异甘草酸镁,而异甘草酸镁改善肝功能的疗效优于丹参注射液.     

Nanomaterials for Inner Ear Diseases: Challenges,Limitations and Opportunities

The inner ear is located deep in the temporal bone and has a complex anatomy. It is difficult to observe and obtain pathological tissues directly. Therefore, the diagnosis and treatment of inner ear diseases have always been a major clinical problem. The onset of inner ear disease can be accompanied by symptoms such as hearing loss, dizziness and tinnitus, which seriously affect people’s lives. Nanoparticles have the characteristics of small size, high bioavailability and strong plasticity. With the development of related research on nanoparticles in inner ear diseases, nanoparticles have gradually become a research hotspot in inner ear diseases. This review briefly summarizes the research progress, opportunities and challenges of the application of nanoparticles in inner ear diseases.     

乙酰紫草素注射液对小鼠Lewis肺癌生长抑制的研究

目的:探讨乙酰紫草素注射液对小鼠Lewis肺癌的生长抑制作用。方法:建立C57BL/6小鼠lewis肺癌模型进行体内抗瘤实验并计算抑瘤率。结果:乙酰紫草素注射液高中低剂量组的抑瘤率分别为55.49%,45.25%和28.09%。结论:乙酰紫草素注射液能明显抑制小鼠Lewis肺癌的生长。     

Analysis of Mechanical Properties Related to Fiber Length of Closed-Loop-Recycled Offcuts of a Thermoplastic Fiber Composites (Organo Sheets)

Increasing demand for energy-efficient means of transport has steadily intensified the trend towards lightweight components. Thermoplastic glass fiber composites (organo sheets) play a major role in the production of functional automotive components. Organo sheets are cut, shaped and functionalized by injection molding to produce hybrid components, such as those used in car door modules. The cutting process produces a considerable amount of production waste, which has thus far been thermally recycled. This study develops a closed mechanical recycling process and analyzes the different steps of the process. The offcuts were shredded using two shredding methods and implemented directly in the injection-molding process. Using tensile tests and impact bending tests, the material properties of the recycled materials were compared with the virgin material. In addition, fiber length degradation via the injection-molding process and the influence of the waterjet-cutting process on the mechanical properties are investigated. Recycled offcuts are both comparable to new material in terms of mechanical properties and usability, and are also economically and ecologically advantageous. Recycling polypropylene waste with glass fiber reinforcement in a closed loop is an effective way to reduce industrial waste in a sustainable and economical production process.     

利培酮口服液合并氯硝西泮治疗精神分裂症急性兴奋的临床研究

目的研究利培酮口服液合并氯硝西泮治疗精神分裂症患者急性兴奋的疗效和安全性。方法将精神分裂症急性兴奋患者87例随机分为两组,治疗组44例予利培酮口服液合并氯硝西泮肌内注射;对照组43例予氟哌啶醇肌内注射,疗程均为7天。采用阳性症状和阴性症状量表（PANSS）评定临床疗效,副作用量表（TESS）评定不良反应。结果治疗7天的疗效相当（P〉0．05）,治疗组不良反应的发生率明显低于对照组（P〈0．05）。结论利培酮口服液合并氯硝西泮治疗精神分裂症急性兴奋疗效肯定,安全性优于氟哌啶醇。     

Biodistribution of Insulin Following Massive Insulin Subcutaneous Injection

A man in his 30s injected insulin several times into his abdomen and was found dead several hours later. Micropathological findings showed alveolar injury with hemorrhaging and cerebral parietal lobe nerve cell edema. Biochemical examinations showed that the blood insulin level was high, significantly so at the insulin injection sites. The blood glucose and C-peptide levels were low. The insulin level in the kidneys was low. In forensic medicine, a postmortem diagnosis of insulin subcutaneous injection is often difficult. When insulin injection is suspected, particularly high insulin levels can be expected at the insulin injection site, rather than in the blood.     

川芎嗪注射液联合补阳还五汤治疗急性脑梗死的效果研究

目的 研究急性脑梗死患者接受川芎嗪注射液联合补阳还五汤的治疗效果。方法 选择医院2018年5月11日—2020年2月18日治疗的100例急性脑梗死患者进行川芎嗪注射液联合补阳还五汤治疗研究,采用电脑随机法分为大剂量组[400 mg川芎嗪注射液+0.9%氯化钠注射液（250 mL）+补阳还五汤]与常规剂量组[80mg川芎嗪注射液+0.9%氯化钠注射液（250 mL）+补阳还五汤],每组各50例急性脑梗死患者,观察血浆黏度、治疗效果、生活质量、凝血功能指标、不良反应、时间指标。结果 治疗后,大剂量组急性脑梗死患者血浆黏度、治疗效果、生活质量、凝血功能指标、时间指标优于常规剂量组急性脑梗死患者,差异有统计学意义（P<0.05）;治疗后,大剂量组急性脑梗死患者不良反应与常规剂量组急性脑梗死患者组间差异无统计学意义（P> 0.05）。结论 在急性脑梗死患者治疗中采用大剂量川芎嗪注射液联合补阳还五汤治疗方案有效改善患者凝血功能指标与血浆黏度,优化急性脑梗死患者脑部血液循环状况,效果十分显著,在急性脑梗死治疗中应用安全性高。