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Soichi Hotta Hiromasa Kashimura Shinji Hirai Akira Nakahara Hisayuki Fukutomi Toshiaki Osuga Yasuo Uchiyama 《Lasers in surgery and medicine》1995,16(3):262-271
Background and Objective: To further understand the precise process of the tumor cell degeneration after photodynamic therapy (PDT), laser hyperthermic therapy (LH), and combined treatments using an Nd:YAG laser. It is important to examine initial morphological alteration of tumor cells after these treatments. Study Design/Materials and Methods: In this study, nude mice bearing HeLa cell tumors were treated with PDT, LH, and combined treatments of the two. Tumor tissues obtained immediately after these treatments were analyzed using electron microscopy and morphometry. Results: In the combined treatments, which produced more severe effects on tumor cells, morphological features of apoptosis such as cytoplasmic condensation, blebs, and apoptotic bodies appeared in the cells, although the typical alteration in the nuclear chromatin was not seen. Conclusion: Cytoplasmic alterations may proceed more rapidly than nuclear alterations in the cellular degeneration induced by the single or combined treatments of PDT and LH. 相似文献
63.
Linkage studies and mutation analysis of the PDEB gene in 23 families with Leber congenital amaurosis. 总被引:1,自引:0,他引:1
The phenotype in the rd mouse is similar to the clinical presentation of Leber congenital amaurosis (LCA) in humans. Recently a nonsense mutation in the beta subunit of the cGMP phosphodiesterase (Pdeb) gene has been defined as the cause for the rd phenotype in the mouse and has raised the question as to whether mutations in the human PDEB gene might cause LCA. We have previously cloned and characterized the human homologue of the mouse Pdeb gene and have mapped it to chromosome 4p16.3. In this study, a total of 23 LCA families of various ethnic backgrounds have been investigated. Linkage analysis using highly polymorphic (CA)n microsatellites has excluded the PDEB gene as a cause for LCA in 6 families. In the remaining 17 families, we have searched for mutations in the 22 exons of the PDEB gene using single-strand gel electrophoresis (SSGE). Multiple exonic polymorphisms have been determined. However, no DNA changes in the PDEB gene have been identified in our study population which could be causative for the LCA phenotype. 相似文献
64.
MRI of the brain in chronic carbon monoxide poisoning 总被引:3,自引:0,他引:3
We examined 13 patients with chronic carbon monoxide (CO) poisoning by magnetic resonance imaging (MRI); all of them had been in an explosion in a coal mine 25 years previously. Symmetrical globus pallidus lesions were observed in 12, as was degeneration of the white matter, with focal cortical atrophy. The temporal parietal and occipital lobes were usually affected, the parietooccipital region being the most frequently and extensively damaged. Of the 12 patients with white matter degeneration 7 had definitely asymmetrical cortical and subcortical lesions. There were 6 patients with dilated temporal horns, probably due to atrophy of the hippocampal gyri. A history of CO inhalation and an awareness of the typical distributions of lesions are important for recognition of the effects of CO poisoning, especially when patients are in the chronic stage. 相似文献
65.
报告手术治疗腰椎间盘突出症合并退行性腰椎管狭窄症104例。术后随访90例,随诊时6个月~6年。优良率86.5%,无腰椎不稳和腰椎滑脱等并发症。为获得优良效果,作者强调在处理椎间盘突出的同时必须彻底解除侧隐窝及神经根管,黄韧带肥厚对神经根的压迫,才能彻底根除症状 相似文献
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67.
Ping Zhao 《中国结合医学杂志》1995,1(3):197-200
AStudyonExtension-FlexionDynamicLumbarSpineRadiographsinPatientswithLumbarIntervertebralDiscHerniationAStudyonExtension-Flexi... 相似文献
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颈椎前路钢板椎间融合器系统治疗颈椎间盘突出症 总被引:1,自引:0,他引:1
颈椎前路手术在颈椎间盘疾病中已广泛应用,手术方法主要为颈前路减压加椎间植骨融合术。但不管是早期的自体骨融合的颈前路手术,还是后来进一步发展的颈前路钢板以及椎间融合器技术,都存在着诸如融合失败率高、植骨块移位、塌陷、螺钉断裂、钢板松动等并发症,造成手术疗效不佳以致于二次手术。自2002年2月-2004年1月采用颈椎间盘摘除、颈椎前路钢板椎间融合器(PCB)系统内固定、植骨融合术治疗颈椎间盘突出症后均无前述并发症的发生,疗效满意,现报道如下。 相似文献
70.