抗HIV药物的研发现状及发展趋势分析

近年来,艾滋病感染人数急剧增加,已成为威胁人类健康的重大疾病。为了解抗人类免疫缺陷病毒（HIV）药物的研究现状和发展趋势,对Thomson Reuters Integrity数据库中收录的抗HIV药物信息进行统计,从药物发展阶段、药物类型、作用靶点和天然来源类型等方面进行分析。研究发现,抗HIV药物大多处于生物测定阶段,生物制品在药物类型中占绝对优势,作用靶点大多数是针对HIV复制周期中的关键酶,抗HIV药物的天然来源以植物为主,天然产物是未来重要的发展方向。     

品管圈在提高手术室护理文书项目填写完整率中的应用

目的：探讨品管圈在提高手术室护理文书项目填写完整率中的应用效果。方法由11人组成品管圈,按品管圈实施步骤对手术室护理文书的书写现状进行把握分析,制定计划、对策并实施。结果手术室护理文书项目填写完整率由57.79%提升到95.45%,圈员能力得到显著提高。结论品管圈活动开展后,手术室护理文书项目填写完整率得到持续改进,效果良好,值得推广应用。     

Prospective multicentre clinical performance evaluation of second and third generation zotarolimus‐eluting stents to treat patients with bifurcated coronary lesions

• The retrograde approach is important for achieving high success rates in chronic total occlusion percutaneous coronary intervention.
• Operators must be aware of complications that can occur during retrograde CTO PCI; they must continually try to prevent them and be ready to treat them, if they occur.
• Systematic, prospective study of complications in CTO PCI is needed for the development of additional preventive and treatment strategies.

     

Circulating Cell Free DNA Integrity Index as a Biomarker for Response to Chemotherapy in Patients with Metastatic Colorectal Carcinoma

Objective: Assessing plasma Cell Free DNA (cfDNA) integrity index as a biomarker for response prediction and early response evaluation in mCRC patients receiving chemotherapy, in comparison to Carcinoembryonic antigen (CEA) and Carbohydrate antigen 19-9 (CA19-9), to be used as an additional tool to computed tomography (CT). Methods: CEA, CA19-9, cfDNA concentration and cfDNA integrity index (ALU 247/115) measurements were conducted on 86 subjects divided into 43 healthy volunteers and 43 mCRC patients, before starting chemotherapy and then after 6-12 weeks of therapy initiation (3-4 cycles FOLFOX) at first response assessment. Plasma cfDNA integrity index was calculated as the ratio of long to short DNA fragments (ALU 247/115) amplified and detected by real-time PCR. Serum CEA and CA19-9 were measured by chemiluminescent immunometric assay. Results: Baseline cfDNA integrity index was statistically significantly different between responders and non-responders (p=0.03). It was found that at cut off 0.608, sensitivity was 73.7%, specificity was 66.7% and diagnostic accuracy=69.77%. Markers with statistical significant difference between responders and non-responders after chemotherapy were CEA % change (p=0.035), CA19-9 (p=0.024), cfDNA integrity index (p=0.035) and cfDNA integrity index % change (p<0.001). Among these markers, cfDNA integrity index % change had the best sensitivity (84.2%), specificity (95.2%) and diagnostic accuracy (90.7%) at cut off -17.827%. Conclusion: Baseline cfDNA integrity index can be used as a potential marker to predict response to chemotherapy. cfDNA integrity index (ALU 247/115) % change rather than its absolute value is superior to CEA, CA19-9, cfDNA concentration and their % changes in early assessment of response to chemotherapy.     

医院廉政文化：内涵、功能与实施路径

医院是社会的特殊单元,以治疗疾病、促进健康的医学实践活动来履行其在社会中的社会职责和发展的。医院廉政文化是具有医疗行业特点的廉政价值观念和精神追求、医疗从业人员职业道德规范和廉洁从业的行为准则、诚信理念和为全社会廉政文化发展产生辐射影响等行业特质内涵,发挥着导向、规范、凝聚、辐射等功能。医院廉政文化既是一种理论,更是实实在在的实践,应做好与医德医风建设、“三好一满意”活动和廉政风险防控管理的有机结合,使廉政文化建设更具系统性,以廉政文化建设提升医院管理水平。     

知觉压力对不育患者精子染色质结构完整性的影响因素分析

目的 探讨男性不育患者心理状态(知觉压力、焦虑、抑郁)及不良生活习惯等对其精子染色质结构完整性损伤的影响,为临床有效护理干预及健康指导提供可靠依据.方法 选取2019年1月至5月兰州大学第一医院生殖医学中心诊治的208例男性不育患者进行调查.采用中文版压力知觉量表(CPSS)、综合性医院焦虑抑郁量表(HAD)及一般情况...     

Zero Watermarking: Critical Analysis of Its Role in Current Medical Imaging

Medical image data plays a critical role in health care today. Whatever the context of image processing (research and educational activities, diagnostic or forensic purposes, etc.), they are supposed to be treated as highly sensitive. Unfortunately, currently available image-processing tools also enable very sophisticated malicious modification of their content.This paper is focused on the assessment of the effectiveness of selected so-called zero watermarking methods (ones that do not cause any modification of an image sample), in the protection of the integrity, and proving authorship, of these medical image studies. We have studied many zero watermarking methods and selected one representative from each type of known algorithms for comparison.We have conducted a series of simulations over a huge research database of anonymized medical image studies (patient examinations).