蔡连香妇科临床用药规律初探

目的：采用数据挖掘法分析名老中医蔡连香的妇科临床用药规律。方法选择蔡连香临床医案165例、共计337诊次的处方资料,用Excel建立数据库,使用中医诊疗大数据智能分析系统进行数据分析,得出高频药物及高频药物组合,并与蔡连香学术思想及临床经验相印证。结果总结出高频药物10味,高频药物组合7组,与蔡连香认为妇科疾病病机以精血不足、肝脾肾三脏失调为主,临床治疗以益精养血、调肝健脾补肾为主要法则的学术观点一致。结论运用数据挖掘的方法总结蔡连香老师的妇科用药规律,对临床具有一定的指导意义。     

Applications of dosimetry modeling to assessment of neurotoxic risk

Risk assessment procedures can be improved through better understanding and use of tissue dose information and linking tissue dose level to adverse outcomes. For volatile organic compounds, such as toluene and trichloroethylene (TCE), blood and brain concentrations can be estimated with physiologically based pharmacokinetic (PBPK) models. Acute changes in the function of the nervous system can be linked to the concentration of test compounds in the blood or brain at the time of neurological assessment. This set of information enables application to a number of risk assessment situations. For example, we have used this approach to recommend duration adjustments for acute exposure guideline levels (AEGLs) for TCE such that the exposure limits for each exposure duration yield identical tissue concentrations at the end of the exposure period. We have also used information on tissue concentration at the time of assessment to compare sensitivity across species, adjusting for species-specific pharmacokinetic differences. Finally this approach has enabled us to compare the relative sensitivity of different compounds on a tissue dose basis, leading to expression of acute solvent effects as ethanol-dose equivalents for purposes of estimating cost–benefit relationships of various environmental control options.     

医院医学工程科技术管理规范专题十——医院医疗器械集中管理技术规范探讨

目的：对医院医疗器械集中管理技术规范进行探讨,以提高使用效率,发挥其经济效益。方法：建立医疗设备集中管理中心,将通用医疗设备采用医院内部租赁方式使用;就集中管理的环境要求、规程经济核算方法、数据统计等进行描述。结果：设备使用率较以往管理方法大大提高,降低了设备购买的支出成本,带来了较高的经济效益和社会效益。结论：各医院从事医院管理的人员可借鉴该方法,更好地为临床一线服务。     

用于妇科血瘀证痛经的四物汤类方——桃红四物汤的研究进展

该文对四物汤类方——桃红四物汤治疗妇科血瘀证的临床应用概况、药理实验、物质基础及药物代谢动力学研究进行归纳,并对该方物质基础与配伍规律的研究思路进行探讨,为方剂现代研究提供参考。     

论中医处方组合规律及其临床运用研究

中医处方由药物配伍组成,它不是随意凑合药物,而是以治法为依据,选择适宜的药物有规律地组合而成,不但要使药物相互协调加强药效,并能减少和缓和某些药物的毒性,从而更好地发挥药物的治疗作用,更能适应临床中比较复杂的病证。因此只有在临床辨证的基础上,依据一定的法则认真分析,从中找出其组合的共同规律,选用适当的药物,规定必要的剂量。针对疾病的病因病机起主要作用的主药,以加强治疗效果的辅助药,治疗兼证或制约主药作用的佐药,起矫味和调和作用的调和药,辨证立法,合理选配药物,组成有效处方,按其规律及临床意义灵活应用于临床。     

新型冠状病毒肺炎危重症中医药干预的必要性思考

新型冠状病毒肺炎(NCP)是一种具有广泛传染、较强致病性的外感疫病,对公众健康造成极大威胁[1-2]。由于病邪侵入人体后传变迅速,疫毒易于弥漫三焦、充斥表里转为危重症,处于危重症时现代医学目前只能对症支持治疗,为恢复危重症患者脏器机能、改善危重症状,配合中医药辨证施治值得深入思考。现以中医整体辨证的视角对新型冠状病毒肺炎所致危重病症辨证梳理,为临床提供一定的借鉴。     

Sequential urn designs with elimination for comparing K > or =3 treatments

A fully sequential procedure is proposed for comparing K > or =3 treatments with immediate binary responses. The procedure uses an adaptive urn design to randomize patients to the treatments and stopping rules are incorporated for eliminating less promising treatments. Simulation is used to assess the performance of the procedure for several adaptive urn designs, in terms of expected numbers of treatment failures and allocation proportions, and the effect on estimation at the end of the trial is also addressed. It is concluded that the drop-the-loser rule is more effective than equal allocation and all of the other designs considered. The practical benefits of the procedure are illustrated using the results of a three-treatment lung cancer study. It is then shown how the sequential elimination procedure may be used in dose-finding studies and its performance is compared with a recently proposed method. Several possible extensions to the work are briefly indicated.     

Enzymatic recovery of silver from waste radiographic film: Optimize with response surface methodology

Silver is one of the valuable materials exist freely on earth crust. Worldwide, massive demand in different purpose makes silver very valuable. On information nearly twenty percent of silver were collected from non-ferrous metallurgical industry, locally generated scrap and photographic film. The toxicity of silver directly impact on surface and ground ecosystem. So it's compulsory to treat and recycle silver from waste material. To fulfil the demand of silver from waste, an enzyme from pineapple make of use. The aim of research work is to recover the silver metal from waste X-ray film by bromelain enzyme as biocatalyst. Response surface methodology full factorial design was used to optimize three operating parameters for maximum recovery of silver. The result shows silver recovery increases with increase in protein concentration, 5.4 mg of pure silver can be recovered from 600 mg of waste X-rays film at most favourable condition of protein concentration 0.2857 mg/ml; temperature 45 °C, pH6.5 and stripping time 20 min. At same optimised parameters, papain biocatalyst shows 4.8 mg and sodium hydroxide shows 5.2 mg recovery of pure silver. The obtained silver powder (grain) having 91.12% purity and total silver recovered.