Reversible hepatic veno-occlusive disease in an infant after consumption of pyrrolizidine-containing herbal tea

Veno-occlusive disease was diagnosed in an 18-month-old boy who had regularly consumed a herbal tea mixture since the 3rd month of life. The boy developed portal hypertension with severe ascites. Histology of the liver showed centrilobular sinusoidal congestion with perivenular bleeding and parenchymal necrosis without cirrhosis. The tea contained peppermint and what the mother thought was coltsfoot (Tussilago farfara). The parents believed the tea aided the healthy development of their child. Pharmacological analysis of the tea compounds revealed high amounts of pyrrolizidine alkaloids. Seneciphylline and the corresponding N-oxide were identified as the major components by thin-layer chromatography, mass spectrometry and NMR spectroscopy. We calculated that the child had consumed at least 60 g/kg body weight per day of the toxic pyrrolizidine alkaloid mixture over 15 months. Macroscopic and microscopic analysis of the leaf material indicated thatAdenostyles alliariae (Alpendost) had been erroneously gathered by the parents in place of coltsfoot. The two plants can easily be confused especially after the flowering period. The child was given conservative treatment only and recovered completely within 2 months.     

消红散对实验性肾小球肾炎小鼠红细胞免疫功能作用机制的研究

目的 研究具有益气健脾摄血功效的消红散对肾小球肾炎(GN)小鼠红细胞免疫功能的影响。方法复制免疫性GN小鼠模型，检测小鼠血中C3b受体花环率及免疫复合物(CIC)、红细胞免疫黏附促进因子(RFER)、红细胞免疫黏附抑制因子(RFIR)的变化。结果消红散能增加GN小鼠的红细胞免疫功能，使C3b受体的数目增加，促使红细胞清除免疫复合物，减少CIC在肾小球基底膜沉积，缓解炎症或CIC介导的病理过程，且能使RFER活性升高，RFIR活性下降。结论 消红散对红细胞免疫功能具有双向调节作用。     

针刺、自主牵引、药物外敷治疗腰椎间盘突出症疗效观察

目的 :观察针刺、自主牵引、药物外敷治疗腰椎间盘突出症 (简称治疗组 )的疗效。方法 :随机分为针刺、自主牵引、药物外敷组和单纯针刺组进行对比观察。结果 :治疗组总有效率 94 .1% ,明显高于对照组 75 .8% ,经统计学处理 ,P <0 .0 5 ,具有显著性差异。结论 :治疗组疗效优于对照组     

伪膜性结肠炎的中医药治疗

目的 :探讨伪膜性结肠炎的中草药治疗效果及安全性。方法 :用艰难梭菌毒素 A& B检测对腹泻患者进行病原性确定 ,采用大蒜汁辅以清热燥湿方剂进行调治 ,每周 1次艰难梭菌毒素 A& B连续检测观察疗效。结果 :1周内临床症状消失率 64.1% (2 5/3 9)、艰难梭菌毒素 A& B转阴率 46.2 % (18/3 9) ,2周内累计临床症状消失率 87.2 % (3 4 /3 9)、艰难梭菌毒素 A& B转阴率 89.7% (3 5/3 9) ,3周内累计临床症状消失率 10 0 .0 % (3 9/3 9)、艰难梭菌毒素 A& B转阴率 97.4% (3 8/3 9) ,艰难梭菌毒素 A& B转阴者连续二次检测无复发。结论 :中草药大蒜汁辅以清热燥湿方剂治疗伪膜性结肠炎用药安全 ,疗效好     

肛欣冲剂治疗肛肠疾病80例疗效观察

目的:观察肛欣冲剂熏洗治疗肛肠疾病的临床疗效。方法:将肛肠病患者120例随机分为2组。治疗组80例应用肛欣冲剂(由马齿苋、五倍子、蛤蟆草、枳壳、芒硝、冰片等组成)治疗,对照组40例用复方荆芥熏洗剂治疗。2组均以10天为1疗程。结果:治疗组临床治愈43例,显效24例,有效7例,无效6例,总有效率92.5％。对照组临床治愈15例,显效11例,有效5例,无效9例,总有效率77.5％,2组总有效率比较,差异有显著性意义(P<0.05),提示治疗组疗效优于对照组。结论:肛欣冲剂在改善肛门疼麻肿胀、下坠、便血、肛门潮湿等常见症状方面,优于复方荆芥熏洗剂。     

补肾宁心益经丸治疗卵巢早衰30例临床观察

目的 观察补肾宁心益经丸治疗卵巢早衰(premature ovarian Failure,POF)的临床疗效.方法 选择60例肾虚型POF患者,随机分为两组各30例.治疗组口服补肾宁心益经丸治疗,对照组口服六味地黄丸,6个月为1个疗程.观察两组治疗前后临床症状、血清卵泡刺激素(FSH)及雌二醇(E2)水平的变化.结果 两组月经情况均有显著改善(P<0.01);治疗组血清FSH明显降低、E2明显升高,较治疗前有显著性差异(P<0.01).治疗组总有效率为70%(21例),对照组为40%(12例),两组比较有显著性差异(P<0.01).结论 补肾宁心益经丸能明显改善POF患者的临床症状和血清内分泌水平.     

伊朗传统医学治疗牙周疾病

目的:牙周疾病非常普遍,尽管有各种特定的治疗方法,但我们始终面临治疗方法有限的问题。考虑到世界组织十分关注传统医学在医疗服务中的发展和应用,我们在一直考察研究伊朗传统医学中药物对牙周疾病的治疗作用。方法:此项研究是一个对有关方面书籍的综合论述,伊朗传统医学内容是经过对重量级作者如Avicenna和Alzahrawy所著的有价值的书籍修订,收集了各医学院校馆藏图书和医药公司的有关信息编辑而成,因为在伊朗传统医学中牙周疾病分成不同目类,对有关药物的研究也被分成8个大组63个题目。(1)缓解牙龈肿胀药物(2)治疗牙龈恶化药物(3)治疗口疮腐烂药物(4)治疗牙龈肥大药物(5)利于伤口康复药物(6)利于牙龈加固的药物(7)阻止牙龈出血的药物(8)防止牙齿松动药物。结果结论:伊朗传统医学在准确的观察和实践的基础上来描述和治疗牙周疾病的。在制药学、有效治疗方面、科学研究手段等领域,伊朗传统医学在以下几个方面可作为现代制药研究的重要资源:(1)纯天然资源(2)容易获得(3)相对比较安全。     

Evaluation of a method to determine the natural occurrence of aflatoxins in commercial traditional herbal medicines from Malaysia and Indonesia

Traditional herbal medicines, popularly known as ‘jamu’ and ‘makjun’ in Malaysia and Indonesia, are consumed regularly to promote health. In consideration of their frequent and prolonged consumption, the natural occurrence of aflatoxins (AF) in these products was determined using immunoaffinity column clean-up and high-performance liquid chromatography with pre-column derivatization. The evaluated method, which entails dilution of sample extracts with Tween 20–phosphate buffered saline (1:9, v/v) and a chromatographic system using isocratic mobile phase composed of water–methanol–acetonitrile (70:20:10, v/v/v), was effective in separating AFB₁, AFG₁ and AFG₂ from interference at their retention times. Results were confirmed using post-column derivatization with photochemical reactor. For 23 commercial samples analyzed, mean levels (incidence) of AFB₁, AFB₂ and AFG₁ in positive samples were 0.26 (70%), 0.07 (61%) and 0.10 (30%) μg/kg, respectively; one sample was positive for AFG₂ at a level of 0.03 (4%) μg/kg. In contrast to the high levels of AF in crude herbal drugs and medicinal plants reported previously by other researchers, the low contamination levels reported in this study may be attributed to the higher selectivity to AF of the method applied. Based on the AFB₁ levels and the daily consumption of positive samples, a mean probable daily intake of 0.022 ng/kg body weight was calculated.     

推拿结合中药熏洗治疗髌下脂肪垫损伤79例

运用推拿结合中药熏洗治疗髌下脂肪垫损伤79例。疗程14～21日。结果：治愈29例，显效35例，好转12例，无效3例；总有效率达96．2％。     

Herbal hepatotoxicity: Analysis of cases with initially reported positive re-exposure tests

BackgroundPositive re-exposure tests are diagnostic hallmarks for hepatotoxicity.ObjectiveTo test validity of positive re-exposures in herb induced liver injury.MethodsWe searched Medline database for cases of herb induced liver injury with positive re-exposures and analysed 34 cases for positive re-exposure test criteria of baseline alanine aminotransferase < 5N before re-exposure, and re-exposure alanine aminotransferase ≥ 2× baseline alanine aminotransferase. Re-exposure test was negative, if baseline alanine aminotransferase < 5N combined with re-exposure alanine aminotransferase < 2× baseline alanine aminotransferase, or if baseline alanine aminotransferase ≥ 5N regardless of the re-exposure alanine aminotransferase including no available re-exposure alanine aminotransferase result.ResultsIn 21/34 cases (61.8%), criteria for a positive re-exposure were fulfilled, with negative tests in 6/34 cases (17.6%) or uninterpretable ones in 7/34 cases (20.6%). Confirmed positive re-exposure tests established potential of herb induced liver injury for Aloe, Chaparral, Chinese herbal mixtures, Chinese Jin Bu Huan, Chinese Syo Saiko To, Germander, Greater Celandine, Green tea, Kava, Mistletoe, Polygonum multiflorum, and Senna, with up to 4 case reports per herb.ConclusionsAmong 34 cases of herb-induced liver injury with initially reported positive re-exposure tests, 61.8% of the cases actually fulfilled established test criteria and provided firm diagnoses of herb induced liver injury by various herbs.