Endoscopic and histopathological evaluation of acute gastric injury in high-dose acetaminophen and nonsteroidal anti-inflammatory drug ingestion with suicidal intent

AIM： To evaluate endoscopic and histopathologic aspects of acute gastric injury due to ingestion of high-dose acetaminophen and nonsteroidal antiinflammatory drugs （NSAIDs） with respect to some risk factors and patient characteristics. METHODS： The study group consists of 50 patients admitted to emergency department with high dose analgesic ingestion （group Ⅰ ） with suicidal intent. Thirty patients with or without mild complaints of dyspepsia （group Ⅱ） were selected as the control group. The study group was stratified according to the use of type and number of analgesics. Endoscopic findings were evaluated according to the Lanza score （LS）, expressing the severity of the gastroduodenal damage and biopsies according to a scoring system based on histopathologic findings of acute erosive gastritis. RESULTS： Gastroduodenal damage was significantly more severe in group Ⅰ compared to group Ⅱ （P 〈 0.01）. The LS was similar in both groups Ⅰ a and Ⅰb. However LS was significantly higher in patients who had ingested multiple NSAIDs （group Ⅰ c） compared to other patients （P 〈 0.01）. The LS was correlated to age （P 〈 0.01） and total amount of drug ingested （P 〈 0.05） in group Ⅰ ; but it was not correlated with Helicobacter pylori （H pylori） infection or duration of exposure （P 〉 0.05）. The biopsy score （BS） was higher in group Ⅰ than group Ⅱ （P 〈 0.01）, and higher in group Ⅰb than group Ⅰa （P 〈 0.05）. CONCLUSION： The histopathologic damage was more severe among NSAID ingesting patients compared to those ingesting only acetaminophen and there is no significant difference in the endoscopic findings between the groups. There is no significant difference in the LS between the groups. This lack of significance is remarkable in terms of the gastric effects of highdose acetaminophen.     

标准化体位宣教图在清醒状态下胃镜检查患者中的应用研究

为探讨标准化体位宣教图在清醒状态下胃镜检查患者中的应用效果, 前瞻性选取北京友谊医院2022年4—5月门诊择期行普通胃镜检查的患者80例, 按随机数字法分为两组, 其中试验组40例, 对照组40例。对照组采用传统的胃镜检查前指导准备方法, 试验组在对照组的基础上联合标准化体位宣教图给予患者检查前指导。记录并比较两组患者体位摆放时间、胃镜检查时间、患者胃镜检查满意度、操作医师满意度以及相关不良反应的发生情况。结果显示, 体位摆放时间试验组为(38.70±3.09)s, 对照组为(50.25±3.12)s, 差异有统计学意义(t=-16.637, P<0.001)。胃镜检查时间试验组为(11.63±1.51)min, 对照组为(15.53±1.69)min, 差异有统计学意义(t=-10.856, P<0.001)。试验组和对照组患者满意度分别是92.5%(37/40)和65.0%(26/40), 操作医师满意度分别是90.0%(36/40)和67.5%(27/40), 差异均有统计学意义(P=0.005, P=0.027)。术后发生恶心的患者试验组1例, 对照组9例, 差异有...     

超细胃镜下钛镍记忆合金覆膜食管支架置入术36例分析

食管支架置入术可有效改善不能行切除的晚期食管癌患者的吞咽困难症状,提高其生活质量。目的:探讨超细胃镜在钛镍记忆合金覆膜食管支架置入术中的临床价值。方法:对36例晚期食管癌、贲门癌合并吞咽困难患者行超细胃镜下钛镍记忆合金覆膜食管支架置入术,选取27例行普通内镜下食管支架置入术的患者作为对照,严重狭窄者预扩张至7 mm。分析支架置放成功率、定位准确性、支架膨胀扩张效果以及患者依从性和并发症情况。结果:超细胃镜组支架置放成功率100%,定位准确,自膨满意,术后吞咽困难评分显著改善(3.22对0.77),患者依从性和各种并发症发生率均优于对照组。结论:超细胃镜下钛镍记忆合金覆膜食管支架置入术成功率高,定位准确,操作简便,患者依从性好。     

经胃镜鼻空肠置管肠内营养在腹部手术后胃瘫的应用

目的:探讨经胃镜鼻空肠置管肠内营养对腹部手术后胃瘫的治疗价值。方法:对21例腹部手术后胃瘫患者进行胃镜检查,对胃镜鼻空肠置管肠内营养的治疗效果进行回顾性分析,观察临床表现、体重、血红蛋白、总蛋白、白蛋白等指标的变化,评价肠内营养支持治疗的效果。结果:所有患者经肠内营养治疗均痊愈,肠内营养后患者体重、血红蛋白、总蛋白、白蛋白均明显提高。结论:经胃镜鼻空肠置管肠内营养能促进胃肠道功能恢复,改善机体营养状况,是一种治疗胃瘫的有效手段。     

幽门螺杆菌与病理同标本检查方法的应用

在华北食管癌高发区开展内镜普查工作中，我们结合农村情况，将内镜采取的活检组织经ＨＰＵＴ试剂盒法检测幽门螺杆菌后，立即以４％的甲醛固定制成石腊切片供病理诊断。这种方法操作简便，效果良好，效率提高，值得推广。     

Documento de posicionamiento de la AEG,la SEED y la SEAP sobre calidad de la endoscopia digestiva alta para la detección y vigilancia de las lesiones precursoras de cáncer gástrico

This position paper, sponsored by the Asociación Española de Gastroenterología [Spanish Association of Gastroenterology], the Sociedad Española de Endoscopia Digestiva [Spanish Gastrointestinal Endoscopy Society] and the Sociedad Española de Anatomía Patológica [Spanish Anatomical Pathology Society], aims to establish recommendations for performing an high quality upper gastrointestinal endoscopy for the screening of gastric cancer precursor lesions (GCPL) in low-incidence populations, such as the Spanish population. To establish the quality of the evidence and the levels of recommendation, we used the methodology based on the GRADE system (Grading of Recommendations Assessment, Development and Evaluation). We obtained a consensus among experts using a Delphi method. The document evaluates different measures to improve the quality of upper gastrointestinal endoscopy in this setting and makes recommendations on how to evaluate and treat the identified lesions. We recommend that upper gastrointestinal endoscopy for surveillance of GCPL should be performed by endoscopists with adequate training, administering oral premedication and use of sedation. To improve the identification of GCPL, we recommend the use of high definition endoscopes and conventional or digital chromoendoscopy and, for biopsies, NBI should be used to target the most suspicious areas of intestinal metaplasia. Regarding the evaluation of visible lesions, the risk of submucosal invasion should be evaluated with magnifying endoscopes and endoscopic ultrasound should be reserved for those with suspected deep invasion. In lesions amenable to endoscopic resection, submucosal endoscopic dissection is considered the technique of choice.     

Splenic artery aneurysm presenting as a submucosal gastric lesion: A case report

We are reporting the rare case of splenic artery aneurysm of 4 cm of diameter presenting as a sub mucosal lesion on gastro-duodenal endoscopy. This aneurysm was treated by endovascular coil embolization and stent graft implantation. The procedure was uneventful. On day 1, the patient presented an acute severe epigastric pain and cardiovascular arrest. Abdominal computed tomography scan showed an active leak of the intravenous contrast dye in the peritoneum from the splenic aneurysm. We performed an emergent resection of the aneurysm, and peritoneal lavage. Postoperatively, hemorrhagic choc was refractory to large volumes replacement, and intravenous vaso-active drugs. On day 2, he presented massive hematochezia. We performed a total colectomy with splenectomy and cholecystectomy for ischemic colitis, with spleen and gallbladder infarction. Despite vaso-active drugs and aggressive treatment with Factor VIIa, the patient died after uncontrolled disseminated intravascular coagulation.     

Primary localized gastric amyloidosis: A scoping review of the literature from clinical presentations to prognosis

Localized gastric amyloidosis (LGA) is a rare disease characterized by abnormal extracellular deposition of amyloid protein restricted to the stomach and it is confirmed by positive results of Congo red staining. Over decades, only a few cases have been reported and studies or research focusing on it are few. Although LGA has a low incidence, patients may suffer a lot from it and require proper diagnosis and management. However, the pathology of LGA remains unknown and no overall review of LGA from its presentations to its prognosis has been published. Patients with LGA are often asymptomatic or manifest atypical symptoms, making it difficult to differentiate from other gastrointestinal diseases. Here, we report the case of a 70-year-old woman with LGA and provide an overview of case reports of LGA available to us. Based on that, we conclude current concepts of clinical manifestations, diagnosis, treatment, and prognosis of LGA, aiming at providing a detailed diagnostic procedure for clinicians and promoting the guidelines of LGA. In addition, a few advanced technologies applied in amyloidosis are also discussed in this review, aiming at providing clinicians with a reference of diagnostic process. With this review, we hope to raise awareness of LGA among the public and clinicians.     

无痛胃镜检查对老年患者血压、心率和血氧饱和度的影响

目的:观察无痛胃镜检查对老年患者血压、心率和血氧饱和度的影响,了解老年患者行无痛胃镜检查的安全性.方法:无痛胃镜检查是在胃镜检查前先予以芬太尼及丙泊酚静脉麻醉.以多功能监护仪监测并记录无痛胃镜检查前、检查中、苏醒时和休息10min患者的收缩压、舒张压、心率和血氧饱和度,并记录不良反应(呛咳、呃逆、呼吸抑制等).结果:与...     

Pólipos gástricos: análisis retrospectivo de 41.253 endoscopias digestivas altas

Introduction

Gastric polyps are usually asymptomatic lesions incidentally discovered during endoscopy.