医学留学生心内科临床见习带教体会

随着医学教育的国际化发展,全国各大医学院校相继开展医学留学生教育,使得这一崭新的课题蓬勃发展。针对留学生的学习特点、师资选拔、课堂教学模式等方面进行了讨论,旨在探索提高医学留学生临床教学质量的方法和途径,为社会培养高素质的临床医学人才。     

A different type of dominoes in the stomach

Ingestion of foreign bodies is one of the common causes of emergency department visits. History, physical examination, and noninvasive imaging such as plain radiography and computer tomography scan can guide us regarding the type and location of the ingested foreign body. Most of the patients can be managed conservatively but few may need endoscopic evaluation and treatment.     

重视开放性眼外伤一期手术处理

开放性眼外伤治疗是一个复杂系统工程,甚至需要多次手术完成.一期缝合修复手术非常关键,其效果直接影响到二期手术治疗后伤眼结构和视功能恢复.现从开放性眼外伤的分区、一期伤口缝合技巧、适应证选择以及合并症的处理等多方面对此问题进行了系统阐述.强调临床医师要高度重视开放性眼外伤一期手术处理方法和时机.     

Comparative Pathogenesis,Genomics and Phylogeography of Mousepox

Ectromelia virus (ECTV), the causative agent of mousepox, has threatened laboratory mouse colonies worldwide for almost a century. Mousepox has been valuable for the understanding of poxvirus pathogenesis and immune evasion. Here, we have monitored in parallel the pathogenesis of nine ECTVs in BALB/cJ mice and report the full-length genome sequence of eight novel ECTV isolates or strains, including the first ECTV isolated from a field mouse, ECTV-MouKre. This approach allowed us to identify several genes, absent in strains attenuated through serial passages in culture, that may play a role in virulence and a set of putative genes that may be involved in enhancing viral growth in vitro. We identified a putative strong inhibitor of the host inflammatory response in ECTV-MouKre, an isolate that did not cause local foot swelling and developed a moderate virulence. Most of the ECTVs, except ECTV-Hampstead, encode a truncated version of the P4c protein that impairs the recruitment of virions into the A-type inclusion bodies, and our data suggest that P4c may play a role in viral dissemination and transmission. This is the first comprehensive report that sheds light into the phylogenetic and geographic relationship of the worldwide outbreak dynamics for the ECTV species.     

赤芝不同部位油脂组成分析

收集不同产地、品种、采收部位和潮次的赤芝孢子粉和子实体,对其含油率、脂肪酸组成进行测定分析,结果表明:全国不同产地的破壁孢子粉含油率为23.61%~34.17%;浙江主栽赤芝品种子实体含油率为0.81%~1.87%,未破壁孢子粉为0.07%~0.24%,破壁孢子粉为27.54%~34.17%,赤芝孢子粉含油率远远大于子实体,破壁加工可提高孢子粉中油脂提取率150~340倍。赤芝孢子油主要由不饱和脂肪酸组成,其中油酸和亚油酸质量分数分别为53.26%~58.16%,10.69%~16.87%;偏最小二乘法判别分析显示,孢子粉和子实体的脂肪酸组成存在明显差异,通过测定脂肪酸组成,尤其是油酸、硬脂酸、棕榈酸的含量,可以鉴别赤芝类产品来源的组织类型。研究还发现同一品种赤芝1潮孢子粉和子实体中含油率和脂肪酸含量均高于2潮。