全文获取类型
收费全文 | 8908篇 |
免费 | 308篇 |
国内免费 | 105篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 260篇 |
妇产科学 | 30篇 |
基础医学 | 1101篇 |
口腔科学 | 90篇 |
临床医学 | 326篇 |
内科学 | 883篇 |
皮肤病学 | 112篇 |
神经病学 | 364篇 |
特种医学 | 88篇 |
外科学 | 125篇 |
综合类 | 495篇 |
预防医学 | 3674篇 |
眼科学 | 45篇 |
药学 | 1394篇 |
1篇 | |
中国医学 | 244篇 |
肿瘤学 | 68篇 |
出版年
2024年 | 20篇 |
2023年 | 176篇 |
2022年 | 330篇 |
2021年 | 410篇 |
2020年 | 436篇 |
2019年 | 382篇 |
2018年 | 388篇 |
2017年 | 220篇 |
2016年 | 306篇 |
2015年 | 317篇 |
2014年 | 566篇 |
2013年 | 527篇 |
2012年 | 466篇 |
2011年 | 755篇 |
2010年 | 414篇 |
2009年 | 401篇 |
2008年 | 483篇 |
2007年 | 404篇 |
2006年 | 261篇 |
2005年 | 226篇 |
2004年 | 169篇 |
2003年 | 138篇 |
2002年 | 106篇 |
2001年 | 69篇 |
2000年 | 83篇 |
1999年 | 58篇 |
1998年 | 58篇 |
1997年 | 49篇 |
1996年 | 43篇 |
1995年 | 48篇 |
1994年 | 37篇 |
1993年 | 28篇 |
1992年 | 34篇 |
1991年 | 35篇 |
1990年 | 25篇 |
1988年 | 21篇 |
1987年 | 23篇 |
1985年 | 98篇 |
1984年 | 86篇 |
1983年 | 72篇 |
1982年 | 76篇 |
1981年 | 54篇 |
1980年 | 75篇 |
1979年 | 73篇 |
1978年 | 52篇 |
1977年 | 38篇 |
1976年 | 42篇 |
1975年 | 29篇 |
1974年 | 32篇 |
1973年 | 28篇 |
排序方式: 共有9321条查询结果,搜索用时 15 毫秒
51.
Control of protein intake was studied in young rats that were allowed to choose between either protein-free and 55% casein diets or 15% and 55% casein diets. Animals on the protein-free vs. 55% casein regimen exhibited a lower weight gain, a lower cumulative energy intake and a greater cumulative total protein intake during the 13-day study compared to rats selecting between 15% and 55% casein. The daily average proportion of total food selected as casein by animals choosing between protein-free and 55% casein diets increased from 15% to 38% during the course of the study. In contrast, rats choosing between 15% and 55% casein chose 18-22% of total food as protein throughout the entire study. Long-term protein intake or protein selection did not correlate significantly with whole-brain contents of 5-HT or 5-HIAA. Our results suggest that protein intake is not regulated at a constant proportion of total calories, but is controlled between a minimum level that will support rapid growth and a maximum that, if exceeded, would require the animal to undergo substantial metabolic adaptation. The mechanism controlling protein selection may involve diet-induced changes in the brain content of total free indispensable amino acids. 相似文献
52.
We examined the factors influencing maternal food intake and pup growth in Norway rats. Mother rats allowed pups in naturally large litters to grow at a slower rate than pups in naturally small litters. Pups reared by dams in a warm ambience (26°C) gained weight more slowly than dams at 22°C, and maternal food intake but not weight gain was depressed in the high ambient temperature. Pup growth at 18°C was unimpaired, with those dams eating no more and gaining no less weight than dams at 22°C. Nest material, however, was found to be essential for the successful rearing of young at cooler ambient temperatures. While restriction of food during gestation resulted in a marginally lower weight gain for the pups during the first 2 weeks postpartum, the dams appeared not to mobilize corporal stores or increase their food intake during lactation. Heavy body weight mothers did not eat any more, nor did they gain any less weight nor rear larger pups than light body weight dams. Rat mothers increased their consumption of a diet diluted with non-nutritive fiber to equal the nutritive intake of their controls, with their pups not differing in their growth rate. Pups reared by dams eating a high quality diet grew faster than pups with dams on the control diet. Food intake by mother rats is required during lactation relative to the amount of milk that is delivered to the pups, rather than to an absolute amount of food. Lactating females with a concurrent pregnancy neither increase their food intake nor appear to mobilize their corporal stores to deal with the added energetic drain of pregnancy. Indeed, their young grew somewhat more quickly than pups nursed by dams that were simply lactating. Taken as a whole, these results suggest that Norway rat dams apparently do not monitor and defend a maximal pup growth rate. Rather, rat dams seem to continue to defend their own homeostasis, and by doing so, allow the young to grow and survive under a wide variety of circumstances. 相似文献
53.
Nutritional studies on rats given a choice between two diets differing in protein content have led to the proposal that brain 5-HT content regulates protein intake [2]. Pharmacologic studies under similar conditions of dietary self-selection suggest that brain 5-HT controls carbohydrate intake [41]. We tested the effect of elevating brain 5-HT via tryptophan injection (100 mg/kg) on short-term food intake and selection by rats choosing between two diets differing in protein and carbohydrate content. Under these conditions neither total food intake nor protein and carbohydrate selection were affected despite increases of 50% in brain concentrations of 5-HT and 5-HIAA. The effect of Trp administration was selective to serotonin metabolism as brain concentrations of NE, DA and DOPAC were not affected. These results suggest that alterations in brain 5-HT content which may occur following meal ingestion may not be of physiological importance in regulating nutrient intake and selection. 相似文献
54.
Central amygdaloid nucleus lesions in rats had no effect on recovery of preoperative body weight and food consumption levels. The brain damaged rats also recovered preoperative levels of water consumption as rapidly as control rats but then developed a mild but persistent hypodipsia. The experimental rats also drank less than control rats when food deprived and showed marginally reliable decreases in 0.1% quinine solution consumption and latency to consume a novel food. There was no detectable lesion effect on 0.1% saccharin solution consumption, exploration of a novel environment or formation of a learned taste aversion. It is suggested that the central amygdaloid nucleus has a role in mediating the relationship between food and water intake and in some taste mediated consummatory behavior. 相似文献
55.
Two experiments, each using approximately 30 male and 30 female hooded rats, examined the effects of electroconvulsive shock (ECS) on water intake as a function of the water deprivation state of the animal and food intake and body weight as a function of food deprivation state. In Experiment 1, half the animals were subjected to water deprivation prior to ECS or sham ECS, and the other half were watered ad lib; in Experiment 2, food deprivation was the pre-ECS manipulation. As predicted, ECS produced a decrease in water intake in the ad lib watered animals but not in the deprived ones. A similar treatment by deprivation interaction was not found for food intake or body weight. In the males, food intake was decreased for one day by the treatment but recovered to a normal level two days following ECS; however, such an effect of ECS on food intake did not occur in the females. Since food and water intake was not differentially affected by ECS and sham ECS in deprived animals, previous cautions regarding ECS effects on motivational states may not be germane to many studies using appetitive conditioning paradigms. 相似文献
56.
Body weight and food intake of lean and obese, male and female Osborne-Mendel rats following treadmill exercise were compared. Rats were assigned, separately by sex, to one of three diet groups; Group 1 was fed a low fat (10%) diet throughout the study, Group 2 was fed a high fat (55%) diet for 16 weeks and then switched to the low fat diet 1 week prior to exercise, and Group 3 was fed the high fat diet throughout the study. To control for differences in work output between the leanest and heaviest animals, exercise intensity was adjusted across groups such that all exercised rats had equivalent energy expenditure. After a 3 day training period, the exercise was successively increased over 8 days until a work output of 374.9J was reached. Relative to their respective controls, obese exercised males showed a reduction in body weight but no change in food intake. In contrast, exercised females showed no change in body weight or food intake, regardless of dietary condition. 相似文献
57.
Four human subjects were fed ad lib with a bland diet for a period of 3 weeks. Their body weight decreased by 3.13 kg during this period. It was observed that the shift of the palatability response to sucrose solutions induced by a gastric glucose load (alliesthesia) was not affected by such a reduction of body weight. This result was compared to a previous experiment showing a decreased alliesthesia after a body weight loss due to the restriction of a palatable diet. These results confirm the role of the palatability of the diet on the maintenance of a body weight level and provide evidence for an interaction between the two factors in determining the oral satiation process. 相似文献
58.
Noradrenergic projections from the dorsomedial medulla reach the shell of the nucleus accumbens (NAcc), a structure implicated in both reward and feeding behavior. Despite this relationship, the effect of food reward on accumbens norepinephrine (NE) remains uninvestigated. In the course of assessing dopamine (DA) in the NAcc during sucrose ingestion [0.03, 0.1, and 0.3 M; Am. J. Physiol., Regul. Integr. Comp. Physiol., 286 (2004) R31], we also analyzed NE in the microdialysis samples from 14 ad-libitum-fed male rats. In contrast to DA, which increased with sucrose concentration (+20-47%) during sham feeding, in the same animals, NE levels were reduced (approximately -20%), regardless of sucrose concentration. These results demonstrate a novel relationship between accumbens DA and NE during orosensory stimulation with a preferred nutrient. 相似文献
59.
60.
M G Tordoff 《Physiology & behavior》1985,35(3):455-463
Rats that were neonatally sympathectomized with guanethidine (GUA) and given access to a four-component supermarket diet (SD) when either adolescent or adult gained weight at the same rate as controls. Adrenodemedullation (MDL) of adults, either alone or in combination with GUA treatment, also failed to influence the development of dietary obesity. Neonatal sympathectomy induced small changes in caloric consumption and diet preferences. These results question the notion that the sympathetic nervous system (SNS) is an essential contributor to the control of body weight and the development of dietary obesity. 相似文献