β_2微球蛋白、Tamm－Horsfall蛋白测定对高血压病和慢性肾炎高血压诊断的临床价值

采用正常人和非高血压慢性肾脏病患者双重对照，测定５４例高血压病和２２例慢性肾炎高血压患者血、尿β２微球蛋白和尿Ｔａｍｍ－Ｈｏｒｓｆａｌｌ蛋白。结果：高血压Ⅰ期血β２微球蛋白增高，Ⅱ和Ⅲ期血、尿β２微球蛋白和β２微球蛋白排泄分数增高，尿Ｔａｍｍ－Ｈｏｒｓｆａｌｌ蛋白降低，提示高血压病可出现肾小球滤过功能损害。随病情发展，近、远端肾小管和管－球平衡功能亦可受损；肾炎高血压β２微球蛋白排泄分数和尿β２微球蛋白明显高于高血压各期，这提示肾炎高血压管－球平衡和近端肾小管功能损害更重，以β２微球蛋白排泄分数≥０．２０％为鉴别高血压病和慢性肾炎高血压的截断值，其准确性为８４％。     

原发性高血压左心室不同构型民律失常的比较

目的 研究原发性高血压患者左心室重构不同构型间心律失常的差异。方法 179例原发性高血压患者均进行了24h动态心电图，动态血压监测，超声心动图等检查，根据检查结果划分左心室构型，判定心律失常，比较左心室重构组与正常构型组心律失常的发生率；通过多元逐步回归分析，甄选出对心律失常有独立影响的因素。并在校正这些影响因素后，比较左心室不同构型间心律失常严重程度的差异。结果 左心室重构组的房性心律失常，室性心律失常，复杂室性心律失常的发生率均显著高于正常构型组，而影响原发性高血压心律失常的相对独立因素很多，其中部分左心室解剖结构指标，高血压分级，左心房内径，E/A值，夜间舒张压负荷值以及日平均心率等占重要地位；校正上述影响因素后，不同构型两两比较时，部分构型之间心律失常分级级别仍存在差异，且差异为构型本知差异所致。结论 原发性高血压心律失常的影响因素很多（例如高血压分级、左心室重量指数，左心房内径，左心室后壁厚度等），不同构型间心律失常的严重程度存在差异。     

高血压病24小时平均脉压与血浆内皮素、一氧化氮关系的探讨

目的　研究 2 4小时平均脉压与血浆内皮素、一氧化氮关系。　方法　对我院住院的原发性高血压病人 70例 ,均在未服药状态下进行动态血压监测。按 2 4小时平均脉压 <6 0mmHg ,6 0mmHg～ 6 9mmHg ,70mmHg～ 79 mmHg,80mmHg～ 89mmHg,90mmHg～ 99mmHg ,>10 0mmHg分成六个组 ,同时测定每个组的血浆内皮素、一氧化氮。　结果　随着 2 4小时平均脉压增加 ,血浆内皮素浓度增加 ,而血浆一氧化氮浓度降低。　结论　高血压患者 2 4小时平均脉压与血浆内皮素成正相关 ,与血浆一氧化氮成负相关     

不同经济水平农村居民原发性高血压危险因素分析

目的 了解不同经济水平农村居民高血压危险因素有无不同.方法 采用自编问卷对河北省冀州市不同经济水平的≥35岁的农村居民中的469名新发高血压患者和2799名对照进行了原发性高血压危险因素调查,并进行了多因素Logistic回归分析.结果 经济水平较好组高血压危险因素(以OR值大小为序)依次为家族史、体质量指数、盐腌食品、每天吃鸡蛋、年龄,它们的OR分别为2.863、1.286、1.263、1.200、1.052;经济水平较差组高血压危险因素(以OR值大小为序)依次为家族史、吸烟、每天吃鸡蛋、饮酒、文化程度、性别、喜吃肥肉、体质量指数、年龄,它们的OR分别为3.990、1.767、 1.753、1.728、1.532、1.448、 1.276、 1.205、1.068,每天吃新鲜水果和家庭年人均收入高是高血压的保护因素,它们的OR为0.708和0.788.结论 经济水平不同高血压危险因素不完全相同.     

比索洛尔治疗原发性高血压180例报告

目的：观察比索洛尔对轻中度高血压的降压疗效及其安全性。方法：采用自身对照开放试验方法。180例原发性高血压（EH）病人，服安慰剂1周后，口服比索洛尔5～20mg（80％病人服5～10mg）共6周，不服其它降血压药。结果：服药6周后血压为18．6±1．77／11．3±1．05kPa，收缩压下降4.0kPa，舒张压下降2．4kPa，有效31．1％，显效67．2％，总有效率98．3％；36例冠心病人中19例心绞痛及心肌缺血好转改善率为52．7％。出现不良反应20例（11．1％），但症状轻，不需停药。治疗前后血生化及肝肾功能无改变。结论：比索洛尔对轻中度EH病人具有降压作用，对合并冠心病者兼有抗缺血效应，不良反应少，耐受性好。     

Composition of the essential oil constituents from leaves and stems of Korean Coriandrum sativum and their immunotoxicity activity on the Aedes aegypti L.

The leaves and stems of Coriandrum sativum were extracted and the essential oil composition and immunotoxicity effects were studied. The analyses were conducted by gas chromatography–mass spectroscopy (GC-MS), which revealed the essential oils of C. sativum leaves and stems. Thirty-nine components representing 99.62% of the total oil were identified from the leaves. The major components are cyclododecanol (23.11%), tetradecanal (17.86%), 2-dodecenal (9.93%), 1-decanol (7.24%), 13-tetradecenal (6.85%), 1-dodecanol (6.54%), dodecanal (5.16%), 1-undecanol (2.28%), and decanal (2.33%). Thirty-eight components representing 98.46% of the total oil were identified from the stems of the coriander. The major components are phytol (61.86%), 15-methyltricyclo[6.5.2(13,14),0(7,15)]-pentadeca-1,3,5,7,9,11,13-heptene (7.01%), dodecanal (3.18%), and 1-dodecanol (2.47%). The leaf oil had significant toxic effects against the larvae of Aedes aegypti with an LC₅₀ value of 26.93?ppm and an LC₉₀ value of 37.69?ppm and the stem oil has toxic effects against the larvae of A. aegypti with an LC₅₀ value of 29.39?ppm and an LC₉₀ value of 39.95?ppm. Also, the above data indicate that the major compounds may play an important role in the toxicity of essential oils.     

Features of “ET plus” correlate with age and tremor duration: “ET plus” may be a disease stage rather than a subtype of essential tremor

BackgroundEssential tremor (ET) is characterized by considerable clinical heterogeneity. In 2018, the term “ET plus” was introduced to mark a potential stratification point for dividing ET into subtypes – ET vs ET plus (i.e., ET cases with neurological features other than action tremor). However, as ET progresses, patients often develop increasingly severe tremor, spread of tremor, tremor under different activation conditions, and other features. Given this situation, ET plus may represent a disease stage rather than a disease classification or subtype. In theory, if the defining characteristics of a disease subtype fluctuate with age or disease duration, it raises the distinct possibility the “subtype” is a disease stage.MethodsA cohort of 241 prospectively enrolled ET cases underwent a detailed motor and cognitive assessment in which the features of ET plus including cerebellar signs (intention tremor, tandem gait difficulty), rest tremor, dystonia, and cognitive performance were evaluated. We determined whether these features of ET plus correlated with action tremor duration and age.ResultsWe demonstrated that numerous ET plus features were significantly correlated with both age and action tremor duration (numerous p values < 0.05). The same relationships were observed in a series of sensitivity analyses.ConclusionWe observed that the component parts of ET plus are highly age- and stage-dependent. These features are yearly-changing features conditional on a demographic and disease stage variable. These data support the notion that ET plus may represent a disease stage rather than a distinct disease subtype or disease classification.