Epidemiological and gynecological correlates with female genital mutilation among Beni-Suef University students; cross sectional study

Objective

This study aims to evaluate the prevalence of FGM/C among university students in Beni-Suef, Egypt and detect the possible socio-demographic and gynaecological associations.

2026名普通高中与重点高中女生痛经及相关心理因素比较

目的了解普通高中与重点高中女生痛经现况及其相关心理因素之间的差异。方法随机分层抽取普通高中女生1 353人、重点高中女生673人,进行问卷调查,采用自编痛经调查问卷和心理健康诊断测验(MHT)。结果重点高中女生痛经率明显比普通高中高,差异有统计学意义(χ2=11.35,P<0.01);痛经组在学习焦虑、过敏倾向、身体症状、恐怖倾向、冲动倾向方面均明显高于非痛经组,差异有统计学意义(P<0.01);痛经组在对人焦虑方面,高于非痛经组,差异有统计学意义(P<0.01);重点高中女生心理问题较普通高中严重。结论多种心理因素与痛经的发生有关,重点高中因学习压力较大,容易导致学生心理失调情况,使痛经的发生率也明显高于普通高中。     

Factors Associated with Increased Pain in Primary Dysmenorrhea: Analysis Using a Multivariate Ordered Logistic Regression Model

Study Objective

In the literature about primary dysmenorrhea (PD), either a pain gradient has been studied just in women with PD or pain was assessed as a binary variable (presence or absence). Accordingly, we decided to carry out a study in young women to determine possible factors associated with intense pain.

针刺三阴交穴治疗痛经的即时临床疗效观察

目的：观察针刺三阴交治疗痛经的即时临床疗效。方法：对36例痛经患者应用针刺三阴交穴治疗疗,并与用芬必得胶囊治疗36例进行即时临床疗效对比。结果：自身对照分析治疗前,治疗后30min,治疗后12h,VAS比较差异均有统计学意义（P〈0．05）,治疗后VAS评分下降。两组治疗前比较（P=0．32〉0．05）两组具有可比性。两组治疗后30rain比较（P〈0．05）治疗组明显优于对照组。两组治疗后12h比较（P〈0．05）治疗组明显优于对照组。结论：针刺三阴交配合艾灸神阙穴治疗痛经有确切疗效。     

针灸治疗原发性痛经的临床疗效及对血液流变学的影响

目的探讨针灸治疗原发性痛经的临床疗效及对血液流变学的影响。方法选择我院2014年4月—2016年3月收治的76例原发性痛经患者为研究对象,以随机数字表法分组,观察组与对照组各38例,对照组单用药物治疗,观察组在药物基础上加针灸治疗,对两组患者疗效与血液流变学水平进行观察。结果观察组与对照组治疗总有效率分别为89.47%、65.79%,两组差异有统计学意义(P0.05);两组患者治疗前的全血黏度、血浆黏度、红细胞压积等血液流变学参数无明显差异(P0.05),治疗后均有改善,且观察组血液流变学参数均低于对照组,差异有统计学意义(P0.05)。结论针灸应用于原发性痛经治疗中效果满意,可有效调节血液流变学,对缓解临床症状具有显著作用,值得临床推广。     

The effectiveness of an educational intervention on proper analgesic use for dysmenorrhea

Objectives

Primary dysmenorrhea is a common gynecologic disorder, but is often inappropriately managed due to ignorance and misunderstanding of its pharmacotherapy in many young women. The aim of this study was to assess the effectiveness of an educational intervention on proper analgesic use for dysmenorrhea among Korean female university students.

Study design

In March 2008, an educational intervention, a 10-min lecture using supplementary educational printed materials, was given to the intervention group (n = 98). Two months later, changes and differences in knowledge, actual medication behavior, coping strategies, dysmenorrhea severity (VAS score), and Korean health-related quality of life (KQOLS) were assessed between the intervention and control (n = 105) groups.

Results

The prevalence of dysmenorrhea in the intervention and control groups was 75.1% and 77.1%, respectively. After the educational intervention, the medication rate of the intervention group was significantly increased (from 36.1% to 51.0%, P = 0.007), and the knowledge of and actual behavior relating to the proper analgesic use were also significantly improved in this group. The VAS scores were significantly decreased among participants with dysmenorrhea in the intervention group (from 48.6 ± 22.0 to 37.8 ± 22.5, P < 0.001). In addition, significant improvements in two domains of the KQOLS, physical function (from 89.3 ± 11.1 to 93.1 ± 8.8, P = 0.007) and pain (from 80.4 ± 19.9 to 87.4 ± 14.3, P = 0.001), were observed in the intervention group.

Conclusions

The findings of this prospective study suggest that a brief educational intervention can improve the severity of dysmenorrhea and the quality of life by enhancing medication knowledge and actual analgesic behavior in Korean female university students.     

Synergistic relaxing effect of the paracetamol and pyrilamine combination in isolated human myometrium

Objective

To evaluate the interaction type of the human uterine relaxant effect of the paracetamol-pyrilamine combination (PPC) in vitro.

Study design

Uterine strips were contracted with KCl (60 mM) and treated with vehicle or increasing concentrations of paracetamol (100-3200 μM), pyrilamine (3.2-100 μM) or the PPC. The relaxing effects of the drugs alone and in combination were measured. Isobolographic analysis was used to determine the pharmacologic interaction type.

Results

Paracetamol, pyrilamine and the PPC produced a significant relaxing effect on non-pregnant human uterine strips pre-contracted with KCl (60 mM). The EC₃₀ values for paracetamol and pyrilamine on the uterine contraction were 2391.3 ± 595.3 μM and 14.7 ± 1.7 μM, respectively. The derived experimental EC₃₀ for the PPC was 401.8 ± 129.8 μM. This value was significantly lower (p < 0.05) than the theoretical EC₃₀ expected for a purely additive interaction, which was 1203.0 ± 297.7 μM for the PPC. The interaction index (γ) was 0.33 ± 0.14 for PPC, being statistically different from unity.

Conclusion

Data suggest that low doses of the PPC can interact synergistically and therefore this drug association may represent a therapeutic advantage for the clinical treatment of dysmenorreic pain.     

Prevalence of primary dysmenorrhea in young adult female university students

Objective  To determine the prevalence of primary dysmenorrhea and attitudes and behavior toward dysmenorrhea in the female students of an university toward this problem. Materials and methods  A total of 1,266 female university students were anonymously surveyed by doctors. Results  It was found that mean age of the surveyed students was 21.02 ± 2.13 years, mean menarche age was 13.3 ± 1.4 years, and menstruation frequency was 32.58 ± 19.8 days. Of the students, 45.3% were found to suffer pain in each menstruation, 42.5% in some and 12.2% in none. Of those with primary dysmenorrhea, 66.9% were established to take analgesic drugs. Conclusion  Prevalence of primary dysmenorrhea was found higher than that cited in the literature. It was established that although the rate of consultation with health professionals about menstruation and related changes was low, use of agents known to be effective in primary dysmenorrhea treatment was highly common.     

Are systemic lupus erythematosus patients carrying MEFV gene less prone to renal involvement? Report of three cases and review of the literature

Abstract

Familial Mediterranean fever (FMF) is an autosomal recessive auto inflammatory disease, characterized by acute attacks of serositis, arthritis or skin rash. Systemic lupus erythematosus (SLE) is a chronic, autoimmune disease characterized by multisystem inflammatory lesions affecting any organ systems in the body. Coexistence of FMF and SLE is rare in literature. In this report, we present three patients with FMF associated with SLE.