复方阿嗪米特联合多潘立酮治疗功能性消化不良疗效观察

目的：观察复方阿嗪米特肠溶片联合多潘立酮片在治疗功能性消化不良中的临床疗效和安全性。方法：将确诊为功能性消化不良74例患者分为A、B两组,A组予复方阿嗪米特肠溶片联合多潘立酮口服,B组予多潘立酮口服,治疗3周,于治疗前后进行症状评分。结果：治疗3周后,A组患者症状总积分较治疗前明显下降（P〈0.01）,且积分下降幅度与B组比较差异有统计学意义（P〈0.01）。A组治疗各种症状及总症状的有效率除了便秘外,均显著优于B组（P〈0.05）。结论：复方阿嗪米特肠溶片联合多潘立酮使用治疗功能性消化不良症状疗效优于单用多潘立酮。     

气滞胃痛颗粒治疗肝胃不和型胆汁反流性胃炎临床观察

目的观察气滞胃痛颗粒治疗肝胃不和型胆汁反流性胃炎临床疗效。方法胆汁反流性胃炎患者136例随机分为2组,治疗组70例予气滞胃痛颗粒5 g,每日3次餐前30 min开水冲服,对照组予铝碳酸镁片1.5 g,每日3次饭后1 h嚼服,多潘立酮片10 mg,每日3次饭前30 min口服。2组均以8周为1个疗程。治疗后2组均做胃镜检查,比较治疗前后各项临床症状积分变化情况以及镜下各项指标积分变化情况。结果2组治疗后各项症状积分较治疗前显著降低,胃镜下所见各项指标积分亦明显降低,总有效率分别为91.4%、74.2%。治疗组总有效率高于对照组（P〈0.05）,改善腹痛、嗳气、纳差症状方面优于对照组（P〈0.05）,显效患者复发率低于对照组（P〈0.05）。结论气滞胃痛颗粒治疗肝胃不和型胆汁反流性胃炎疗效满意,复发率低。     

香砂六君子汤治疗慢性胃炎的中医药临床优势研究

【目的】观察香砂六君子汤辨证加味治疗慢性胃炎的临床效果,以及香砂六君子汤对中医证候和胃镜检查结果的疗效区别,探讨现代医学模式下中医药的临床治疗优势并指导临床实践。【方法】将90例慢性胃炎患者随机分为对照组和治疗组,每组各45例。对照组给予奥美拉唑片联合多潘立酮片治疗,4周为1个疗程,幽门螺旋杆菌(Hp)阳性者加用阿莫西林胶囊、甲硝唑片,1周后停用抗菌素,1个疗程结束后评估证候积分及复查胃镜。治疗组在对照组方案的基础上加用香砂六君子汤辨证加味治疗。【结果】(1)中医证候疗效:治疗1个疗程后,治疗组的总有效率为93.3%,对照组为66.7%,治疗组的中医证候疗效优于对照组,差异有统计学意义(P0.05)。(2)胃镜疗效:治疗组的总有效率为86.7%,对照组为68.9%,治疗组的胃镜疗效优于对照组,差异有统计学意义(P0.05)。(3)2种疗效评价方法评价结果比较:经Mann-Whitney U秩和检验,治疗组的中医证候疗效优于胃镜疗效,差异有统计学意义(Z=-1.974,P0.05),而对照组2种评价方法的疗效未表现出统计学差异(Z=-0.662,P0.05),表明治疗组应用中医药治疗对证候的改善效果尤其明显。【结论】相对于单纯的西药治疗,香砂六君子汤辨证加味联合西药能明显提高慢性胃炎的治疗效果;中医药对证候的改善具有更好的效果,在以证候尤其是患者自我感觉不适为主要表现的情况下,中医药以及中西医结合治疗具有明显优势。     

雷尼替丁、吗丁啉、果胶铋合用治疗反流性食管炎66例临床分析

目的:研究雷尼替丁、吗丁啉、果胶铋联合用药治疗反流性食管炎的疗效。方法:对66例反流性食管炎患者,采用口服雷尼替丁、吗丁啉、果胶铋4-8周。结果:显效26例(39.4％);有效31例(47.0％);有效率86.4％;无效9例(13.6％)。结论:雷尼替丁、吗丁啉、果胶铋联合用药对治疗反流性食管炎有效。     

Cardiovascular reflexes in Parkinson's disease: Effect of domperidone and apomorphine

Cardiovascular reflexes were evaluated in 18 patients with idiopathic Parkinson's disease who had a Hoehn & Yahr score of III–IV. The effect of apomorphine and domperidone on blood pressure, heart rate, R—R interval variation, and the Valsalva ratio were studied. Autonomic dysfunction was not found in the patients and there were no differences between subgroups of patients on different treatments. Apomorphine altered cardiovascular reflexes to a greater degree in patients who received the drug for the first time than in chronically treated patients. The changes were antagonized by domperidone, a peripheral dopamine receptor antagonist. Apomorphine treated patients who were receiving long-term domperidone had similar abnormalities of cardiovascular reflexes to those who had been able to withdraw it.     

Increased serum prolactin but normal TSH during prolonged domperidone treatment in children

The influence of the dopamine receptor blocking agent domperidone on prolactin and TSH secretion was studied in 16 infants, aged 10–360 days, who were treated for gastroesophageal reflux. The pretreatment serum prolactin levels were not statistically different from the levels in age-matched controls and showed the well-known inverse relationship with age. During treatment with domperidone a significant increase in prolactin level was observed on days 1, 4 and 21–28, the mean values on these three days not being statistically different. No correlation could be found between the serum prolactin levels and the corresponding plasma domperidone levels. One infant of this series and three not included in this series developed reversible breast hypertrophy with galactorrhoea in three of them: in none of them was the prolactin level, corrected for age, above 1 SD of the mean. All had received relatively high doses of domperidone. In 13 patients domperidone did not influence TSH secretion.     

疏肝和胃降逆汤治疗反流性食管炎临床研究

目的:观察疏肝和胃降逆汤治疗反流性食管炎的临床疗效。方法:将本院经明确诊断为反流性食管炎患者81例,采用随机数字表法分为观察组41例和对照组40例,对照组采用口服奥美拉唑肠溶片和多潘立酮片治疗,观察组采用疏肝和胃降逆汤治疗,两组均治疗8周。结果:观察组临床综合疗效有效率为95.12%、胃镜疗效有效率为92.68%,明显高于对照组的综合疗效有效率77.50%和胃镜疗效有效率72.50%,比较具有显著性差异(P0.05)。经过8周治疗,两组患者中医症状积分和RDQ积分均较治疗前显著下降(P0.05),观察组较对照组下降更显著(P0.05)。两组治疗后随访6个月,观察组复发率为7.32%,对照组复发率为27.50%,观察组复发率明显低于对照组(χ2=4.44,P0.05)。结论:疏肝和胃降逆汤能有效改善患者的临床症状,降低复发率。     

莫沙必利联合前列地尔治疗糖尿病胃轻瘫的临床观察

目的：探讨莫沙必利联合前列地尔治疗糖尿病胃轻瘫（DGP）的疗效。方法选取该院2009年1月至2012年7月消化内分泌科明确诊断为DGP的患者75例,随机分为观察组（35例）和对照组（40例）,观察组患者给予莫沙必利联合前列地尔治疗,对照组患者给予多潘立酮治疗,观察两组临床症状疗效,比较随访3、6个月的复发率。结果治疗后观察组总有效率[88.57%（31/35）]高于对照组[67.50（27/40）],3、6个月复发率均低于对照组,差异均有统计学意义（P〈0.05）。结论莫沙必利联合前列地尔是DGP治疗的有效方法,值得临床应用。     

多潘立酮联合复方消化酶治疗功能性消化不良的疗效分析

目的分析观察功能性消化不良采用多潘立酮联合复方消化酶治疗的临床效果。方法选择2011年4月至2013年4月来我中心就诊的功能性消化不良患者120例,随机分为2组,对照组和观察组各60例,观察组给予多潘立酮联合复方消化酶治疗,对照组给予多潘立酮治疗,用药4周后观察治疗效果。结果观察组的有效率为98.4%,对照组的有效率为84.5%,两组比较差异有统计学意义(P<0.05)。结论功能性消化不良采用多潘立酮联合复方消化酶治疗效果比较满意,不良反应较少,可以在临床应用。